scholarly journals Estrogen-induced circRNA, circPGR, functions as a ceRNA to promote estrogen receptor-positive breast cancer cell growth by regulating cell cycle-related genes

Theranostics ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 1732-1752
Author(s):  
Lei Wang ◽  
Jia Yi ◽  
Ling-yun Lu ◽  
Yue-ying Zhang ◽  
Lan Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Estrogen Receptor ◽  
Cell Growth ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Estrogen Receptor Positive ◽  
Positive Breast Cancer Cell ◽  
Positive Breast Cancer

scholarly journals High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth

2013 ◽  
Vol 8 (1) ◽  
pp. 93-104 ◽  
Author(s):  
Suvi-Katri Leivonen ◽  
Kristine Kleivi Sahlberg ◽  
Rami Mäkelä ◽  
Eldri Undlien Due ◽  
Olli Kallioniemi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Breast Cancer Cell ◽  
High Throughput ◽  
Her2 Positive ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Positive Breast Cancer Cell ◽  
High Throughput Screens ◽  
Positive Breast Cancer

scholarly journals MicroRNA-203 Regulates Growth and Metastasis of Breast Cancer

2015 ◽  
Vol 37 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Shan Zhao ◽  
Jinzhu Han ◽  
Likang Zheng ◽  
Zixin Yang ◽  
Li Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Normal Breast ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

Backgrounds/Aims: MicroRNAs (MiRNAs) control many biological events and play critical roles in the development of tumor. Among all miRNAs, miR203 has been recently shown to have an inhibitory effect on prostate cancer. However, its involvement in the carcinogenesis of breast cancer has not been reported. Methods: We examined the levels of miR203 in the breast cancer from the patients compared to the paired normal breast tissue. We also examined the levels of miR203 in several commonly used breast cancer cell lines. The effects of overexpression or depletion of miR203 on breast cancer cell growth were analyzed by a MTT assay, and on breast cancer cell invasion were examined by a scratch wound healing assay and a transwell cell migration assay. MiR203-targeted genes were analyzed by Western blot. Results: We detected significantly lower levels of miR203 in the breast cancer from the patients compared to the paired normal breast tissue. Moreover, the levels of miR203 were significantly lower in breast cancer tissue from the patients with cancer metastasis. Decreased miR203 levels were detected in all examined breast cancer lines. Overexpression of miR203 inhibited breast cancer cell growth and invasion, while antisense-mediated inhibition of miR203 enhanced cancer cell growth and invasion. Further analyses show that miR203 may inhibit cell growth through decreasing cell-cycle activator cyclinD2 and CDK6, increasing cell-cycle suppressor p21 and p27, and increasing apoptosis-associated protein Bcl-2. MiR203 may also inhibit cell metastasis through suppressing matrix metalloproteinase 2 (MMP2), MMP7 and MMP9. Conclusion: Our data thus highlight miR203 as a novel therapeutic target for breast cancer.

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