scholarly journals FOXK2 Transcription Factor Suppresses ERα-positive Breast Cancer Cell Growth Through Down-Regulating the Stability of ERα via mechanism involving BRCA1/BARD1

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Ying Liu ◽  
Xiang Ao ◽  
Zhaojun Jia ◽  
Xiao-Yan Bai ◽  
Zhaowei Xu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Positive Breast Cancer Cell ◽  
The Stability ◽  
Positive Breast Cancer

scholarly journals RASSF1A Suppresses Estrogen-Dependent Breast Cancer Cell Growth through Inhibition of the Yes-Associated Protein 1 (YAP1), Inhibition of the Forkhead Box Protein M1 (FOXM1), and Activation of Forkhead Box Transcription Factor 3A (FOXO3A)

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2689
Author(s):  
Sven Roßwag ◽  
Gitta Thiede ◽  
Jonathan P. Sleeman ◽  
Sonja Thaler
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Forkhead Box ◽  
Cancer Initiation ◽  
And Function

The estrogen receptor alpha (ERα) is expressed by the majority of breast cancers and plays an important role in breast cancer development and tumor outgrowth. Although ERα is well known to be a specific and efficient therapeutic target, the molecular mechanisms that are responsible for the control of ERα expression and function in the context of breast cancer initiation and progression are complex and not completely elucidated. In previous work, we have demonstrated that the tumor suppressor RASSF1A inhibits ERα expression and function in ERα-positive breast cancer cells through an AKT-dependent mechanism. Transcriptional activators such as forkhead box protein M1 (FOXM1) and forkhead transcription factor 3A (FOXO3A) and signaling pathways such as the Hippo pathway are also known to modulate ERα expression and activity. Here we report that RASSF1A acts as an inhibitor of ERα-driven breast cancer cell growth through a complex, hierarchically organized network that initially involves suppression of the Hippo effector Yes-associated protein 1 (YAP1), which is followed by inhibition of AKT1 activity, increased FOXO3A activity as well as a blockade of FOXM1 and ERα expression. Together our findings provide important new mechanistic insights into how the loss of RASSF1A contributes to ERα+ breast cancer initiation and progression.

scholarly journals The AP-1 transcription factor regulates breast cancer cell growth via cyclins and E2F factors

Oncogene ◽  
2007 ◽  
Vol 27 (3) ◽  
pp. 366-377 ◽  
Author(s):  
Q Shen ◽  
I P Uray ◽  
Y Li ◽  
T I Krisko ◽  
T E Strecker ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth

scholarly journals High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth

2013 ◽  
Vol 8 (1) ◽  
pp. 93-104 ◽  
Author(s):  
Suvi-Katri Leivonen ◽  
Kristine Kleivi Sahlberg ◽  
Rami Mäkelä ◽  
Eldri Undlien Due ◽  
Olli Kallioniemi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Breast Cancer Cell ◽  
High Throughput ◽  
Her2 Positive ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Positive Breast Cancer Cell ◽  
High Throughput Screens ◽  
Positive Breast Cancer

CFP suppresses breast cancer cell growth by TES-mediated upregulation of the transcription factor DDIT3

Oncogene ◽  
2019 ◽  
Vol 38 (23) ◽  
pp. 4560-4573 ◽  
Author(s):  
Ines Block ◽  
Carolin Müller ◽  
Daniel Sdogati ◽  
Henriette Pedersen ◽  
Markus List ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcription Factor ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth
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