scholarly journals G9a-mediated repression of CDH10 in hypoxia enhances breast tumour cell motility and associates with poor survival outcome

Theranostics ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 4515-4529 ◽  
Author(s):  
Francesco Casciello ◽  
Fares Al-Ejeh ◽  
Mariska Miranda ◽  
Greg Kelly ◽  
Eva Baxter ◽  
...  
Keyword(s):  
Cell Motility ◽  
Tumour Cell ◽  
Breast Tumour ◽  
Survival Outcome ◽  
Poor Survival ◽  
Breast Tumour Cell ◽  
Poor Survival Outcome

scholarly journals Retroperitoneal Extragastrointestinal Stromal Tumors Have a Poor Survival Outcome: A Multicenter Observational Study

2020 ◽  
Vol Volume 12 ◽  
pp. 10491-10504
Author(s):  
Weixian Hu ◽  
Chengbin Zheng ◽  
Renjie Li ◽  
Xingyu Feng ◽  
Guoliang Zheng ◽  
...  
Keyword(s):  
Observational Study ◽  
Survival Outcome ◽  
Poor Survival ◽  
Multicenter Observational Study ◽  
Stromal Tumors ◽  
Poor Survival Outcome

Breast tumour cell subpopulations with expression of the MYC and OCT4 proteins

2020 ◽  
Vol 51 (6) ◽  
pp. 717-728
Author(s):  
N. V. Litviakov ◽  
V. A. Bychkov ◽  
M. N. Stakheeva ◽  
M. K. Ibragimova ◽  
M. M. Tsyganov ◽  
...  
Keyword(s):  
Tumour Cell ◽  
Breast Tumour ◽  
Breast Tumour Cell ◽  
Cell Subpopulations

scholarly journals LAMA4 upregulation is associated with high liver metastasis potential and poor survival outcome of Pancreatic Cancer: Erratum

Theranostics ◽  
2021 ◽  
Vol 11 (20) ◽  
pp. 10171-10172
Author(s):  
Biao Zheng ◽  
Jianhua Qu ◽  
Kenoki Ohuchida ◽  
Haimin Feng ◽  
Stephen Jun Fei Chong ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Liver Metastasis ◽  
Survival Outcome ◽  
Poor Survival ◽  
Poor Survival Outcome ◽  
High Liver

scholarly journals Quantitative hormone receptor (HR) expression and gene expression analysis in HR+ inflammatory breast cancer (IBC) vs non-IBC

2020 ◽  
Author(s):  
Toshiaki Iwase ◽  
Kenichi Harano ◽  
Hiroko Masuda ◽  
Kumiko Kida ◽  
Kenneth R. Hess ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Inflammatory Breast Cancer ◽  
Hormone Receptor ◽  
Survival Outcome ◽  
Stage Iii ◽  
Prognostic Role ◽  
Poor Survival ◽  
Poor Survival Outcome

Abstract Purpose: The purpose of this study was to determine the prognostic role of hormone receptor (HR) on inflammatory breast cancer (IBC) to elucidate its aggressive biological behavior.Methods: We evaluated the expression of estrogen receptor (ER) and progesterone receptor (PR) by immunohistochemical staining and determined the predictive and prognostic role of HR expression on 189 patients with HR+/HER2– IBC and 677 patients with HR+/HER2– stage III non-IBC. Furthermore, we performed gene expression (GE) analyses for 137 patients with HR+/HER2– IBC and 252 patients with corresponding non-IBC to detect genes that are specifically overexpressed in IBC.Results: The expression of ER% was significantly associated with longer distant disease-free survival and overall survival. However, there was no significant relationship between ER% and NAC outcome. In the GE study, 84 genes were identified as significantly distinguishing HR+ IBC from non-IBC. Among the top 15 canonical pathways expressed in IBC, the ERK/MAPK, PDGF, insulin receptor, and IL-7 signaling pathways were associated with the ER signaling pathway. Upregulation of the MYC gene was observed in three of these four pathways. Furthermore, HR+/HER2– IBC had significantly higher MYC amplification, and the genetic alteration was associated with poor survival outcome.Conclusions: Increased HR positivity was significantly associated with improved survival in both HR+/HER2– IBC and HR+/HER2– stage III non-IBC patients. HR+/HER2– IBC had several activated pathways with MYC upregulation, and the genetic alteration was associated with poor survival outcome. The results indicate that MYC may be a key gene for understanding the biology of HR+/HER2– IBC.

scholarly journals Increased expression of microRNA-26a-5p predicted a poor survival outcome in osteosarcoma patients

Medicine ◽  
2021 ◽  
Vol 100 (12) ◽  
pp. e24765
Author(s):  
Xiao-Yu Xie ◽  
Xian-Ming Chen ◽  
Ling Shi ◽  
Jun-Wei Liu
Keyword(s):  
Survival Outcome ◽  
Poor Survival ◽  
Poor Survival Outcome

scholarly journals The differential processing of proenkephalin A in mouse and human breast tumour cell lines

1999 ◽  
Vol 161 (3) ◽  
pp. 475-484 ◽  
Author(s):  
BK Brar ◽  
PJ Lowry
Keyword(s):  
Cell Line ◽  
Cell Lines ◽  
Tumour Cell ◽  
Breast Tumour ◽  
Human Breast ◽  
Human Breast Tumour ◽  
Breast Tumour Cell ◽  
Cell Lysates ◽  
Human Breast Tumour Cell ◽  
Tumour Cell Lines

We have carried out an investigation into the processing of the enkephalin-like immunoreactivity reported in breast tissue using two human breast tumour cell lines and a mouse tumour cell line. A 46 kDa form of proenkephalin (PE) has been observed in the cell lysates of two human breast tumour cell lines (MCF-7, ZR-75-1) and the mouse androgen-responsive Shionogi breast carcinoma cell line (SC115). PE processing in the cell lysates of these cells was assessed by a specific met-enkephalin RIA. The basal levels of processed PE in the MCF-7, ZR-75-1 and SC115 cell lysates were 30, 30 and 76% respectively. The processing enzymes PC1 and PC2, which have been implicated in the differential processing of PE, were detected by immunoblot analysis in these cells. PC1 was found within the cell extracts of all three cell lines. PC2 was only observed in the SC115 cell line, which may account for the higher percentage of processed PE measured. The cDNA of PC2 has been transfected into ZR-75-1 cells and this was accompanied by an increase in the level of processed PE from 30 to 76%. These breast tumour cell lines may provide a useful insight into the function of enkephalin-containing peptides in breast cancer.

scholarly journals Promoter Methylation of CDO1 Identifies Clear-Cell Renal Cell Cancer Patients with Poor Survival Outcome

2015 ◽  
Vol 21 (15) ◽  
pp. 3492-3500 ◽  
Author(s):  
Ivette A.G. Deckers ◽  
Leo J. Schouten ◽  
Leander Van Neste ◽  
Iris J.H. van Vlodrop ◽  
Patricia M.M.B. Soetekouw ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Renal Cell Cancer ◽  
Promoter Methylation ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Cancer ◽  
Survival Outcome ◽  
Poor Survival ◽  
Poor Survival Outcome
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