scholarly journals Inhibition of SMYD2 suppresses tumor progression by down-regulating microRNA-125b and attenuates multi-drug resistance in renal cell carcinoma

Theranostics ◽  
2019 ◽  
Vol 9 (26) ◽  
pp. 8377-8391 ◽  
Author(s):  
Libin Yan ◽  
Beichen Ding ◽  
Haoran Liu ◽  
Yangjun Zhang ◽  
Jin Zeng ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Drug Resistance ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Multi Drug Resistance

scholarly journals Inhibition of SMYD2 suppresses tumor progression by down-regulating microRNA-125b and attenuates multi-drug resistance in renal cell carcinoma: Erratum

Theranostics ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 419-420
Author(s):  
Libin Yan ◽  
Beichen Ding ◽  
Haoran Liu ◽  
Yangjun Zhang ◽  
Jin Zeng ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Drug Resistance ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Multi Drug Resistance

scholarly journals Adiponectin-AdipoR1 axis in renal cell carcinoma plays a pivotal role in tumor progression and drug resistance

2018 ◽  
Vol 29 ◽  
pp. viii314 ◽  
Author(s):  
G. Sun ◽  
X. Zhang ◽  
J. Zhao ◽  
J. Chen ◽  
P. Shen ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Drug Resistance ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Pivotal Role

scholarly journals MUC13 overexpression in renal cell carcinoma plays a central role in tumor progression and drug resistance

2017 ◽  
Vol 140 (10) ◽  
pp. 2351-2363 ◽  
Author(s):  
Yonghua Sheng ◽  
Choa Ping Ng ◽  
Rohan Lourie ◽  
Esha T. Shah ◽  
Yaowu He ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Drug Resistance ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Renal Cell

scholarly journals MicroRNA-451 regulates chemoresistance in renal cell carcinoma by targeting ATF-2 gene

2017 ◽  
Vol 242 (12) ◽  
pp. 1299-1305 ◽  
Author(s):  
Xiang Sun ◽  
Longhua Lou ◽  
Kezhao Zhong ◽  
Lijuan Wan
Keyword(s):  
Renal Cell Carcinoma ◽  
Drug Resistance ◽  
Cell Viability ◽  
Cell Carcinoma ◽  
Cell Line ◽  
Cell Lines ◽  
Cell Apoptosis ◽  
Renal Cell ◽  
Luciferase Reporter ◽  
Multi Drug Resistance

Renal cell carcinoma (RCC) is a malignant tumor, which severely threatens human’s life, moreover, the multi-drug resistance (MDR) under RCC undoubtedly strengthen the difficulties in the treatment. MiR-451 has been considered to play an important role in regulation of MDR in several cancers, but the role of it in MDR of RCC has not been explored. This study aims to explore the mechanism of miR-451 as a target to regulate chemotherapy resistance, which is crucial for further exploring novel therapy for RCC. Two human cell lines (ACHN and GRC-1) were performed in this study and adriamycin (ADM) was used to construct MDR cell lines. qRT-PCR was used to determine the mRNA expression of miR-451 and ATF-2. Weston blot was used to determine protein expression. MTT assay and flow cytometry were used for assessing cell viability and apoptosis, individually. Luciferase reporter assay was used to detect the targeting of miR-451 and ATF-2. Results presented that the expression of miR-451 was higher in low MDR cell line (ACHN) comparing with the high MDR cell line (GRC-1), while the expression of ATF-2 revealed an opposite results. MiR-451 targeted ATF-2 and regulated its expression. Overexpression of miR-451 strengthened drug resistance, decreased cell viability, and increased cell apoptosis of GRC-1 pretreated by ADM, while overexpressed ATF-2 reversed the effect induced by miR-451 overexpression. Then miR-451 knockdown improved drug susceptibility, decreased cell apoptosis, and increased cell viability of ACHN induced by ADM, however, ATF-2 suppression reversed the low rate of cell apoptosis and high rate of cell viability induced by miR-451 knockdown. Our results revealed that miR-451 regulates the drug resistance of RCC by targeting ATF-2 gene, which might be critical for overcoming MDR in RCC patients. Impact statement This is the first study to emphasize the expression of miR-451 on regulating multi-drug resistance (MDR) in renal cell carcinoma (RCC). Our study found that miR-451 regulates the drug resistance of RCC by targeting ATF-2, which might be critical for overcoming MDR in RCC patients. This study not only provides solid theory foundation for the clinical therapy, but also offers unique insights for the further RCC research. Furthermore, the study helps us to understand the mechanism of MDR, which was crucial for identifying the chemoresistance on several related tumors.

scholarly journals Interleukin-6 induces drug resistance in renal cell carcinoma

2018 ◽  
Vol 64 (3) ◽  
pp. 103-110 ◽  
Author(s):  
Kei Ishibashi ◽  
Tomoyuki Koguchi ◽  
Kanako Matsuoka ◽  
Akifumi Onagi ◽  
Ryo Tanji ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Drug Resistance ◽  
Cell Carcinoma ◽  
Interleukin 6 ◽  
Renal Cell

scholarly journals MMP9 and IGFBP1 Regulate Tumor Immune and Drive Tumor Progression in Clear Cell Renal Cell Carcinoma

2021 ◽  
Vol 12 (8) ◽  
pp. 2243-2257
Author(s):  
Tianbo Xu ◽  
Su Gao ◽  
Jingchong Liu ◽  
Yu Huang ◽  
Ke Chen ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma
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