scholarly journals MMP9 and IGFBP1 Regulate Tumor Immune and Drive Tumor Progression in Clear Cell Renal Cell Carcinoma

2021 ◽  
Vol 12 (8) ◽  
pp. 2243-2257
Author(s):  
Tianbo Xu ◽  
Su Gao ◽  
Jingchong Liu ◽  
Yu Huang ◽  
Ke Chen ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma

αB-Crystallin in clear cell renal cell carcinoma: Tumor progression and prognostic significance

2013 ◽  
Vol 31 (7) ◽  
pp. 1367-1377 ◽  
Author(s):  
Pei-Yin Ho ◽  
Shih-Chieh Chueh ◽  
Shyh-Horng Chiou ◽  
Shuo-Meng Wang ◽  
Wei-Chou Lin ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Prognostic Significance ◽  
Cell Renal Cell Carcinoma ◽  
Αb Crystallin ◽  
Carcinoma Tumor

scholarly journals HAVCR/KIM-1 Activates the IL-6/STAT-3 Pathway in Clear Cell Renal Cell Carcinoma and Determines Tumor Progression and Patient Outcome

2014 ◽  
Vol 74 (5) ◽  
pp. 1416-1428 ◽  
Author(s):  
Thaïs Cuadros ◽  
Enric Trilla ◽  
Eduard Sarró ◽  
Maya R. Vilà ◽  
Jordi Vilardell ◽  
...  
Keyword(s):  
Patient Outcome ◽  
Renal Cell Carcinoma ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma

scholarly journals SPOP promotes tumor progression via activation of β-catenin/TCF4 complex in clear cell renal cell carcinoma

2016 ◽  
Vol 49 (3) ◽  
pp. 1001-1008 ◽  
Author(s):  
Wencai Zhao ◽  
Jiancheng Zhou ◽  
Zhuo Deng ◽  
Yang Gao ◽  
Yongyi Cheng
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma

scholarly journals Genomic Instability Promotes the Progression of Clear Cell Renal Cell Carcinoma Through Influencing the Immune Microenvironment

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiyi Wei ◽  
Yichun Wang ◽  
Chengjian Ji ◽  
Jiaocheng Luan ◽  
Liangyu Yao ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Genomic Instability ◽  
Renal Cell ◽  
Clear Cell ◽  
Immune Microenvironment ◽  
Cell Renal Cell Carcinoma ◽  
Low Expression

Background: Long non-coding RNAs (lncRNAs) are now under discussion as novel promising biomarkers for clear cell renal cell carcinoma (ccRCC). However, the role of genomic instability-associated lncRNA signatures in tumors has not been thoroughly uncovered. The purpose of our study is to probe the role of genomic instability-derived lncRNA signature (GILncSig) and to further investigate the mechanism of genomic instability-mediated ccRCC progression.Methods: The transcriptome data and somatic mutation profiles of ccRCC as well as clinical characteristics used in this study were obtained from The Cancer Genome Atlas database and Gene Expression Omnibus database. Lasso regression analysis was performed to construct the GILncSig. Gene set enrichment analysis (GSEA) was performed to elucidate the biological functions and relative pathways. CIBERSORT and EPIC algorithm were applied to calculate the proportion of immune cells in ccRCC. ESTIMATE algorithm was utilized to compute the immune microenvironment scores.Results: In total, 148 novel genomic instability-derived lncRNAs in ccRCC were identified. Immediately, on the basis of univariate cox analysis and lasso analysis, a GILncSig was appraised, through which the patients were allocated into High-Risk and Low-Risk groups with significantly different characteristics and prognoses. In addition, we confirmed that the somatic mutation count, tumor mutation burden, and the expression of UBQLN4, which were ascertainably associated with genomic instability, were significantly correlated with the GILncSig, indicating its reliability as a measurement of the genomic instability. Furthermore, the efficiency of GILncSig in prognostic aspects was better than the single mutation gene in ccRCC. In addition, MNX1-AS1 was defined to be a potential biomarker characterized by strong correlation with clinical features. Moreover, GSEA results indicated that the IL6/JAK/STAT3/SIGNALING pathway could be considered as a potential mechanism of genomic instability to influence tumor progression. Besides, the immune microenvironment showed significant differences between the GS-like group and the GU-like group, which was specifically manifested as high expression of CTLA4, GITR, TNFSF14, and regulatory T cells (Tregs) as well as low expression of endothelial cells (ECs) in the GU-like group. Finally, the prognostic value and clinical relevance of GILncSig were verified in GEO datasets and other urinary tumors in TCGA dataset.Conclusion: In conclusion, our study provided a new perspective for the role of lncRNAs in genomic instability and revealed that genomic instability may mediate tumor progression by affecting immunity. Besides, MNX1-AS1 played critical roles in promoting the progression of ccRCC, which may be a potential therapeutic target. What is more, the immune atlas of genomic instability was characterized by high expression of CTLA4, GITR, TNFSF14, and Tregs, and low expression of ECs.

scholarly journals Identification of gene expression profile in low risk clear cell renal cell carcinoma to predict tumor progression

2020 ◽  
Vol 19 ◽  
pp. e1961
Author(s):  
F.L. Roldan Chavez ◽  
M. Ingelmo-Torres ◽  
J.J. Lozano ◽  
M. Ramirez-Backhaus ◽  
J. Rubio ◽  
...  
Keyword(s):  
Gene Expression ◽  
Renal Cell Carcinoma ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Renal Cell ◽  
Clear Cell ◽  
Low Risk ◽  
Cell Renal Cell Carcinoma
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