scholarly journals Advances in Surface Enhanced Raman Spectroscopy for in Vivo Imaging in Oncology

2022 ◽  
Vol 6 (1) ◽  
pp. 31-49
Author(s):  
Kenry ◽  
Fay Nicolson ◽  
Louise Clark ◽  
Sajanlal R. Panikkanvalappil ◽  
Bohdan Andreiuk ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
In Vivo Imaging ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

scholarly journals Surface-Enhanced Raman Spectroscopy for Cancer Immunotherapy Applications: Opportunities, Challenges, and Current Progress in Nanomaterial Strategies

Nanomaterials ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 1145 ◽  
Author(s):  
Shuvashis Dey ◽  
Matt Trau ◽  
Kevin M. Koo
Keyword(s):  
Raman Spectroscopy ◽  
Cancer Immunotherapy ◽  
Immune Checkpoint ◽  
Checkpoint Inhibitors ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Checkpoint Receptors

Cancer immunotherapy encompasses a variety of approaches which target or use a patient’s immune system components to eliminate cancer. Notably, the current use of immune checkpoint inhibitors to target immune checkpoint receptors such as CTLA-4 or PD-1 has led to remarkable treatment responses in a variety of cancers. To predict cancer patients’ immunotherapy responses effectively and efficiently, multiplexed immunoassays have been shown to be advantageous in sensing multiple immunomarkers of the tumor microenvironment simultaneously for patient stratification. Surface-enhanced Raman spectroscopy (SERS) is well-regarded for its capabilities in multiplexed bioassays and has been increasingly demonstrated in cancer immunotherapy applications in recent years. This review focuses on SERS-active nanomaterials in the modern literature which have shown promise for enabling cancer patient-tailored immunotherapies, including multiplexed in vitro and in vivo immunomarker sensing and imaging, as well as immunotherapy drug screening and delivery.

scholarly journals Surface-enhanced Raman spectroscopy for in vivo biosensing

2017 ◽  
Vol 1 (8) ◽  
Author(s):  
Stacey Laing ◽  
Lauren E. Jamieson ◽  
Karen Faulds ◽  
Duncan Graham
Keyword(s):  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Spiers Memorial Lecture : Surface-enhanced Raman spectroscopy: from single particle/molecule spectroscopy to ångstrom-scale spatial resolution and femtosecond time resolution

2017 ◽  
Vol 205 ◽  
pp. 9-30 ◽  
Author(s):  
Anne-Isabelle Henry ◽  
Tyler W. Ueltschi ◽  
Michael O. McAnally ◽  
Richard P. Van Duyne
Keyword(s):  
Raman Spectroscopy ◽  
Spatial Resolution ◽  
Single Molecule ◽  
Time Resolution ◽  
Glucose Sensor ◽  
Surface Enhanced Raman Spectroscopy ◽  
Memorial Lecture ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Four decades on, surface-enhanced Raman spectroscopy (SERS) continues to be a vibrant field of research that is growing (approximately) exponentially in scope and applicability while pushing at the ultimate limits of sensitivity, spatial resolution, and time resolution. This introductory paper discusses some aspects related to all four of the themes for this Faraday Discussion. First, the wavelength-scanned SERS excitation spectroscopy (WS-SERES) of single nanosphere oligomers (viz., dimers, trimers, etc.), the distance dependence of SERS, the magnitude of the chemical enhancement mechanism, and the progress toward developing surface-enhanced femtosecond stimulated Raman spectroscopy (SE-FSRS) are discussed. Second, our efforts to develop a continuous, minimally invasive, in vivo glucose sensor based on SERS are highlighted. Third, some aspects of our recent work in single molecule SERS and the translation of that effort to ångstrom-scale spatial resolution in ultrahigh vacuum tip-enhanced Raman spectroscopy (UHV-TERS) and single molecule electrochemistry using electrochemical (EC)-TERS will be presented. Finally, we provide an overview of analytical SERS with our viewpoints on SERS substrates, approaches to address the analyte generality problem (i.e. target molecules that do not spontaneously adsorb and/or have Raman cross sections <10−29 cm2 sr−1), SERS for catalysis, and deep UV-SERS.

scholarly journals In vivo multiplex molecular imaging of vascular inflammation using surface-enhanced Raman spectroscopy

Theranostics ◽  
2018 ◽  
Vol 8 (22) ◽  
pp. 6195-6209 ◽  
Author(s):  
Jonathan Noonan ◽  
Steven M. Asiala ◽  
Gianluca Grassia ◽  
Neil MacRitchie ◽  
Kirsten Gracie ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Molecular Imaging ◽  
Vascular Inflammation ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Nanoplasmonic biopatch for in vivo surface enhanced raman spectroscopy

2014 ◽  
Vol 8 (4) ◽  
pp. 289-294 ◽  
Author(s):  
Sang-Gil Park ◽  
Myeong-Su Ahn ◽  
Young-Jae Oh ◽  
Minseok Kang ◽  
Yong Jeong ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

scholarly journals New Insight into Erythrocyte through In Vivo Surface-Enhanced Raman Spectroscopy

2009 ◽  
Vol 97 (12) ◽  
pp. 3206-3214 ◽  
Author(s):  
Nadezda A. Brazhe ◽  
Salim Abdali ◽  
Alexey R. Brazhe ◽  
Oksana G. Luneva ◽  
Nadezda Y. Bryzgalova ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Insight Into

In Vivo Glucose Measurement by Surface-Enhanced Raman Spectroscopy

2006 ◽  
Vol 78 (20) ◽  
pp. 7211-7215 ◽  
Author(s):  
Douglas A. Stuart ◽  
Jonathan M. Yuen ◽  
Nilam Shah ◽  
Olga Lyandres ◽  
Chanda R. Yonzon ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Glucose Measurement ◽  
Surface Enhanced ◽  
Surface Enhanced Raman
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