scholarly journals Dual-modality optical diagnosis for precise in vivo identification of tumors in neurosurgery

Theranostics ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 2827-2842 ◽  
Author(s):  
Mingyu Zhu ◽  
Wei Chang ◽  
Linkai Jing ◽  
Yingwei Fan ◽  
Ping Liang ◽  
...  
Keyword(s):  
Optical Diagnosis ◽  
Dual Modality

Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging

2016 ◽  
Vol 8 (7) ◽  
pp. 4378-4384 ◽  
Author(s):  
Dawei Jiang ◽  
Yanhong Sun ◽  
Jiang Li ◽  
Qian Li ◽  
Min Lv ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Tumor Targeting ◽  
Dna Nanostructures ◽  
Dual Modality

scholarly journals Immunocompatibility of a new dual modality contrast agent based on radiolabeled iron-oxide nanoparticles

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maria-Argyro Karageorgou ◽  
Dimosthenis Stamopoulos
Keyword(s):  
Complete Blood Count ◽  
Morphological Characteristics ◽  
Mononuclear Phagocyte ◽  
Dual Modality ◽  
Immunodeficient Mice ◽  
Force Microscopy ◽  
Magnetic Resonance Imaging Mri ◽  
Diagnostic Applications

AbstractRadiolabeled magnetic nanoparticles are promising candidates as dual-modality-contrast-agents (DMCA) for diagnostic applications. The immunocompatibility of a new DMCA is a prerequisite for subsequent in vivo applications. Here, a new DMCA, namely Fe3O4 nanoparticles radiolabeled with 68Ga, is subjected to immunocompatibility tests both in vitro and in vivo. The in vitro immunocompatibility of the DMCA relied on incubation with donated human WBCs and PLTs (five healthy individuals). Optical microscopy (OM) and atomic force microscopy (AFM) were employed for the investigation of the morphological characteristics of WBCs and PLTs. A standard hematology analyzer (HA) provided information on complete blood count. The in vivo immunocompatibility of the DMCA was assessed through its biodistribution among the basic organs of the mononuclear phagocyte system in normal and immunodeficient mice (nine in each group). In addition, Magnetic Resonance Imaging (MRI) data were acquired in normal mice (three). The combined OM, AFM and HA in vitro data showed that although the DMCA promoted noticeable activation of WBCs and PLTs, neither degradation nor clustering were observed. The in vivo data showed no difference of the DMCA biodistribution between the normal and immunodeficient mice, while the MRI data prove the efficacy of the particular DMCA when compared to the non-radiolabeled, parent CA. The combined in vitro and in vivo data prove that the particular DMCA is a promising candidate for future in vivo applications.

scholarly journals Initial in vitro and in vivo assessment of Au@DTDTPA-RGD nanoparticles for Gd-MRI and 68Ga-PET dual modality imaging

2015 ◽  
Vol 2 (Suppl 1) ◽  
pp. A89 ◽  
Author(s):  
Charalmpos Tsoukalas ◽  
Gautier Laurent ◽  
Gloria Jiménez Sánchez ◽  
Theodoros Tsotakos ◽  
Rana Bazzi ◽  
...  
Keyword(s):  
Dual Modality ◽  
Dual Modality Imaging ◽  
In Vivo Assessment

In vivo NIRF and MR dual-modality imaging using glycol chitosan nanoparticles

2012 ◽  
Vol 163 (2) ◽  
pp. 249-255 ◽  
Author(s):  
Jaehong Key ◽  
Christy Cooper ◽  
Ah Young Kim ◽  
Deepika Dhawan ◽  
Deborah W. Knapp ◽  
...  
Keyword(s):  
Chitosan Nanoparticles ◽  
Glycol Chitosan ◽  
Dual Modality ◽  
Dual Modality Imaging

Accuracy of In-Vivo Optical Diagnosis of Colon Polyp Histology by Narrow Band Imaging (NBI) in Predicting Colonoscopy (CC) Surveillance Intervals (SI)

2011 ◽  
Vol 140 (5) ◽  
pp. S-119
Author(s):  
Neil Gupta ◽  
Deepthi S. Rao ◽  
Dayna S. Early ◽  
Steven A. Edmundowicz ◽  
Sreenivasa S. Jonnalagadda ◽  
...  
Keyword(s):  
Narrow Band ◽  
Narrow Band Imaging ◽  
Colon Polyp ◽  
Optical Diagnosis

scholarly journals Intrinsically Germanium-69-Labeled Iron Oxide Nanoparticles: Synthesis and In-Vivo Dual-Modality PET/MR Imaging

2014 ◽  
Vol 26 (30) ◽  
pp. 5119-5123 ◽  
Author(s):  
Rubel Chakravarty ◽  
Hector F. Valdovinos ◽  
Feng Chen ◽  
Christina M. Lewis ◽  
Paul A. Ellison ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Dual Modality ◽  
Nanoparticles Synthesis
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