Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging

2016 ◽  
Vol 8 (7) ◽  
pp. 4378-4384 ◽  
Author(s):  
Dawei Jiang ◽  
Yanhong Sun ◽  
Jiang Li ◽  
Qian Li ◽  
Min Lv ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Tumor Targeting ◽  
Dna Nanostructures ◽  
Dual Modality

scholarly journals Dual-modality gene reporter for in vivo imaging

2013 ◽  
Vol 111 (1) ◽  
pp. 415-420 ◽  
Author(s):  
P. S. Patrick ◽  
J. Hammersley ◽  
L. Loizou ◽  
M. I. Kettunen ◽  
T. B. Rodrigues ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Dual Modality

Passive Tumor Targeting of Polymer Therapeutics: In Vivo Imaging of Both the Polymer Carrier and the Enzymatically Cleavable Drug Model

2016 ◽  
Vol 16 (11) ◽  
pp. 1577-1582 ◽  
Author(s):  
Robert Pola ◽  
Anne-Kathrin Heinrich ◽  
Thomas Mueller ◽  
Libor Kostka ◽  
Karsten Mäder ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Tumor Targeting ◽  
Polymer Carrier ◽  
Polymer Therapeutics

scholarly journals In vivo Imaging-Guided Nanoplatform for Tumor Targeting Delivery and Combined Chemo-, Gene- and Photothermal Therapy

Theranostics ◽  
2018 ◽  
Vol 8 (20) ◽  
pp. 5662-5675 ◽  
Author(s):  
Cheng Li ◽  
Xiao-Quan Yang ◽  
Ming-Zhen Zhang ◽  
Yuan-Yang Song ◽  
Kai Cheng ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Targeting Delivery

Indocyanine green-loaded biodegradable tumor targeting nanoprobes for in vitro and in vivo imaging

Biomaterials ◽  
2012 ◽  
Vol 33 (22) ◽  
pp. 5603-5609 ◽  
Author(s):  
Cuifang Zheng ◽  
Mingbin Zheng ◽  
Ping Gong ◽  
Dongxue Jia ◽  
Pengfei Zhang ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
In Vivo Imaging ◽  
Tumor Targeting

Dual-modality in vivo imaging for MRI detection of tumors and NIRF-guided surgery using multi-component nanoparticles

2011 ◽  
Author(s):  
Jaehong Key ◽  
Kwangmeyung Kim ◽  
Deepika Dhawan ◽  
Deborah W. Knapp ◽  
Ick Chan Kwon ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Dual Modality ◽  
Guided Surgery

scholarly journals Development of theranostic dual-layered Au-liposome for effective tumor targeting and photothermal therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Miyeon Jeon ◽  
Gaeun Kim ◽  
Wooseung Lee ◽  
Seungki Baek ◽  
Han Na Jung ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Therapeutic Strategy ◽  
Tumor Growth Inhibition ◽  
Positron Emission ◽  
Anti Cancer ◽  
Good Biocompatibility ◽  
Targeting Ability

Abstract Background Photothermal therapy (PTT) is an emerging anti-cancer therapeutic strategy that generates hyperthermia to ablate cancer cells under laser irradiation. Gold (Au) coated liposome (AL) was reported as an effective PTT agent with good biocompatibility and excretory property. However, exposed Au components on liposomes can cause instability in vivo and difficulty in further functionalization. Results Herein, we developed a theranostic dual-layered nanomaterial by adding liposomal layer to AL (LAL), followed by attaching polyethylene glycol (PEG) and radiolabeling. Functionalization with PEG improves the in vivo stability of LAL, and radioisotope labeling enables in vivo imaging of LAL. Functionalized LAL is stable in physiological conditions, and 64Cu labeled LAL (64Cu-LAL) shows a sufficient blood circulation property and an effective tumor targeting ability of 16.4%ID g−1 from in vivo positron emission tomography (PET) imaging. Also, intravenously injected LAL shows higher tumor targeting, temperature elevation in vivo, and better PTT effect in orthotopic breast cancer mouse model compared to AL. The tumor growth inhibition rate of LAL was 3.9-fold higher than AL. Conclusion Based on these high stability, in vivo imaging ability, and tumor targeting efficiency, LAL could be a promising theranostic PTT agent. Graphic Abstract

scholarly journals In vivo co-registered hybrid-contrast imaging by successive photoacoustic tomography and magnetic resonance imaging

2021 ◽  
Author(s):  
Shuangyang Zhang ◽  
Li Qi ◽  
Xipan Li ◽  
Zhichao Liang ◽  
Jian Wu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Soft Tissue ◽  
In Vivo Imaging ◽  
Molecular Probe ◽  
Photoacoustic Tomography ◽  
Resonance Imaging ◽  
Dual Modality ◽  
Wide Range

AbstractMagnetic resonance imaging (MRI) and photoacoustic tomography (PAT) are two advanced imaging modalities that offer two distinct image contrasts: MRI has a multi-parameter contrast mechanism that provides excellent anatomical soft tissue contrast, whereas PAT is capable of mapping tissue physiological metabolism and exogenous contrast agents with optical specificity. Attempts have been made to integrate these two modalities, but rigid and reliable registration of the images for in vivo imaging is still challenging. In this paper, we present a complete hardware-software solution for the successive acquisition and co-registration of PAT and MRI images in in vivo animal studies. Based on commercial PAT and MRI scanners, our solution includes a 3D-printed dual-modality animal imaging bed, a 3-D spatial image co-registration algorithm with bi-model markers, and a robust modality switching protocol for in vivo imaging studies. Using the proposed solution, we successfully demonstrated co-registered hybrid-contrast PAT-MRI imaging that simultaneously display multi-scale anatomical, functional and molecular characteristics on healthy and cancerous living mice. Week-long longitudinal dual-modality imaging of tumor development reveals information on size, border, vascular pattern, blood oxygenation, and molecular probe metabolism of the tumor micro-environment at the same time. Additionally, by incorporating soft-tissue information in the co-registered MRI image, we further show that PAT image quality could be enhanced by MRI-guided light fluence correction. The proposed methodology holds the promise for a wide range of pre-clinical research applications that benefit from the PAT-MRI dual-modality image contrast.

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