scholarly journals A Positive Feedback Loop of SLP2 Activates MAPK Signaling Pathway to Promote Gastric Cancer Progression

Theranostics ◽  
2018 ◽  
Vol 8 (20) ◽  
pp. 5744-5757 ◽  
Author(s):  
Wenhui Ma ◽  
Zhuoluo Xu ◽  
Yutian Wang ◽  
Wenyi Li ◽  
Zhigang Wei ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Positive Feedback Loop ◽  
Gastric Cancer Progression

scholarly journals miR-577 Regulates TGF-β Induced Cancer Progression through a SDPR-Modulated Positive-Feedback Loop with ERK-NF-κB in Gastric Cancer

2019 ◽  
Vol 27 (6) ◽  
pp. 1166-1182 ◽  
Author(s):  
Yuhao Luo ◽  
Jianhua Wu ◽  
Qianying Wu ◽  
Xiaoyin Li ◽  
Jiani Wu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Progression ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Positive Feedback Loop

scholarly journals LGR6 activates the Wnt/β-catenin signaling pathway and forms a β-catenin/TCF7L2/LGR6 feedback loop in LGR6high cervical cancer stem cells

Oncogene ◽  
2021 ◽  
Author(s):  
Qian Feng ◽  
Shan Li ◽  
Hong-Mei Ma ◽  
Wen-Ting Yang ◽  
Peng-Sheng Zheng
Keyword(s):  
Cervical Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Western Blotting ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Stem Cell Marker ◽  
Positive Feedback Loop

AbstractThe leucine-rich repeat-containing G-protein-coupled receptor 6 (LGR6) is considered to be a stem cell marker in many normal tissues and promotes tissue development, regeneration, and repair. LGR6 is also related to the initiation and progression of some malignant tumors. However, the role of LGR6 in cervical cancer has not been reported. Here, immunohistochemistry and western blotting showed that LGR6 was significantly upregulated in cervical cancer, compared with the normal cervix. By analyzing The Cancer Genome Atlas database, LGR6 was found to be correlated with a poor prognosis of cervical cancer. Then, a small population of LGR6high cells isolated by using the fluorescence-activated cell sorting exhibited enhanced properties of cancer stem cells including self-renewal, differentiation, and tumorigenicity. Moreover, RNA sequencing revealed that LGR6 was correlated with the Wnt signaling pathway and TOP/FOP, reverse transcription-PCR, and western blotting further proved that LGR6 could activate the Wnt/β-catenin signaling pathway. Interestingly, LGR6 upregulated the expression of TCF7L2 by activating the Wnt/β-catenin pathway. Then, TCF7L2 combining with β-catenin in the nucleus enhanced LGR6 transcription by binding the promoter of LGR6, which further activated the Wnt signaling to form a positive feedback loop. Thus, our study demonstrated that LGR6 activated a novel β-catenin/TCF7L2/LGR6-positive feedback loop in LGR6high cervical cancer stem cells (CSCs), which provided a new therapeutic strategy for targeting cervical CSCs to improve the prognosis of cervical cancer patients.

Sign in / Sign up

Export Citation Format

Share Document