scholarly journals Solamargine inhibits gastric cancer progression by regulating the expression of lncNEAT1_2 via the MAPK signaling pathway

2019 ◽  
Author(s):  
Runjia Fu ◽  
Xiaohong Wang ◽  
Ying Hu ◽  
Hong Du ◽  
Bin Dong ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Gastric Cancer Progression

scholarly journals A Positive Feedback Loop of SLP2 Activates MAPK Signaling Pathway to Promote Gastric Cancer Progression

Theranostics ◽  
2018 ◽  
Vol 8 (20) ◽  
pp. 5744-5757 ◽  
Author(s):  
Wenhui Ma ◽  
Zhuoluo Xu ◽  
Yutian Wang ◽  
Wenyi Li ◽  
Zhigang Wei ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Positive Feedback Loop ◽  
Gastric Cancer Progression

LINC00665 induces gastric cancer progression through activating Wnt signaling pathway

2019 ◽  
Vol 121 (3) ◽  
pp. 2268-2276 ◽  
Author(s):  
Bo Yang ◽  
Qingqing Bai ◽  
Huidong Chen ◽  
Kun Su ◽  
Chao Gao
Keyword(s):  
Gastric Cancer ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Wnt Signaling Pathway ◽  
Gastric Cancer Progression

scholarly journals Underexpressed CNDP2 Participates in Gastric Cancer Growth Inhibition through Activating the MAPK Signaling Pathway

2013 ◽  
Vol 20 (1) ◽  
pp. 17-28 ◽  
Author(s):  
Zhenwei Zhang ◽  
Lei Miao ◽  
Xiaoming Xin ◽  
Jianpeng Zhang ◽  
Shengsheng Yang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Growth Inhibition ◽  
Signaling Pathway ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Cancer Growth

scholarly journals SPON2 Is Upregulated through Notch Signaling Pathway and Promotes Tumor Progression in Gastric Cancer

Cancers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1439
Author(s):  
Hyeon-Gu Kang ◽  
Won-Jin Kim ◽  
Myung-Giun Noh ◽  
Kyung-Hee Chun ◽  
Seok-Jun Kim
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Notch Signaling Pathway ◽  
Migration And Invasion ◽  
Gene Assay ◽  
Gastric Cancer Progression

Spondin-2 (SPON2) is involved in cancer progression and metastasis of many tumors; however, its role and underlying mechanism in gastric cancer are still obscure. In this study, we investigated the role of SPON2 and related signaling pathway in gastric cancer progression and metastasis. SPON2 expression levels were found to be upregulated in gastric cancer cell lines and patient tissues compared to normal gastric epithelial cells and normal controls. Furthermore, SPON2 silencing was observed to decrease cell proliferation and motility and reduce tumor growth in xenograft mice. Conversely, SPON2 overexpression was found to increase cell proliferation and motility. Subsequently, we focused on regulatory mechanism of SPON2 in gastric cancer. cDNA microarray and in vitro study showed that Notch signaling is significantly correlated to SPON2 expression. Therefore, we confirmed how Notch signaling pathway regulate SPON2 expression using Notch signaling-related transcription factor interaction and reporter gene assay. Additionally, activation of Notch signaling was observed to increase cell proliferation, migration, and invasion through SPON2 expression. Our study demonstrated that Notch signaling-mediated SPON2 upregulation is associated with aggressive progression of gastric cancer. In conclusion, we suggest upregulated SPON2 via Notch signaling as a potential target gene to inhibit gastric cancer progression.

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