scholarly journals In vivo multiplex molecular imaging of vascular inflammation using surface-enhanced Raman spectroscopy

Theranostics ◽  
2018 ◽  
Vol 8 (22) ◽  
pp. 6195-6209 ◽  
Author(s):  
Jonathan Noonan ◽  
Steven M. Asiala ◽  
Gianluca Grassia ◽  
Neil MacRitchie ◽  
Kirsten Gracie ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Molecular Imaging ◽  
Vascular Inflammation ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

scholarly journals Surface-Enhanced Raman Spectroscopy for Cancer Immunotherapy Applications: Opportunities, Challenges, and Current Progress in Nanomaterial Strategies

Nanomaterials ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 1145 ◽  
Author(s):  
Shuvashis Dey ◽  
Matt Trau ◽  
Kevin M. Koo
Keyword(s):  
Raman Spectroscopy ◽  
Cancer Immunotherapy ◽  
Immune Checkpoint ◽  
Checkpoint Inhibitors ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Checkpoint Receptors

Cancer immunotherapy encompasses a variety of approaches which target or use a patient’s immune system components to eliminate cancer. Notably, the current use of immune checkpoint inhibitors to target immune checkpoint receptors such as CTLA-4 or PD-1 has led to remarkable treatment responses in a variety of cancers. To predict cancer patients’ immunotherapy responses effectively and efficiently, multiplexed immunoassays have been shown to be advantageous in sensing multiple immunomarkers of the tumor microenvironment simultaneously for patient stratification. Surface-enhanced Raman spectroscopy (SERS) is well-regarded for its capabilities in multiplexed bioassays and has been increasingly demonstrated in cancer immunotherapy applications in recent years. This review focuses on SERS-active nanomaterials in the modern literature which have shown promise for enabling cancer patient-tailored immunotherapies, including multiplexed in vitro and in vivo immunomarker sensing and imaging, as well as immunotherapy drug screening and delivery.

scholarly journals Surface-enhanced Raman spectroscopy for in vivo biosensing

2017 ◽  
Vol 1 (8) ◽  
Author(s):  
Stacey Laing ◽  
Lauren E. Jamieson ◽  
Karen Faulds ◽  
Duncan Graham
Keyword(s):  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Development of a sensitive, stable and EGFR-specific molecular imaging agent for surface enhanced Raman spectroscopy

2015 ◽  
Vol 46 (5) ◽  
pp. 434-446 ◽  
Author(s):  
Leanne J. Lucas ◽  
Claudio Tellez ◽  
Maiara L. Castilho ◽  
Christopher L. D. Lee ◽  
Michael A. Hupman ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Molecular Imaging ◽  
Surface Enhanced Raman Spectroscopy ◽  
Imaging Agent ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Molecular Imaging Agent

scholarly journals Molecular imaging of atherosclerosis: spotlight on Raman spectroscopy and surface-enhanced Raman scattering

Heart ◽  
2017 ◽  
Vol 104 (6) ◽  
pp. 460-467 ◽  
Author(s):  
Neil MacRitchie ◽  
Gianluca Grassia ◽  
Jonathan Noonan ◽  
Paul Garside ◽  
Duncan Graham ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Molecular Imaging ◽  
Spatial Resolution ◽  
High Spatial Resolution ◽  
Photon Emission ◽  
Surface Enhanced Raman Spectroscopy ◽  
Emission Tomography ◽  
Good Spatial Resolution ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

To accurately predict atherosclerotic plaque progression, a detailed phenotype of the lesion at the molecular level is required. Here, we assess the respective merits and limitations of molecular imaging tools. Clinical imaging includes contrast-enhanced ultrasound, an inexpensive and non-toxic technique but with poor sensitivity. CT benefits from high spatial resolution but poor sensitivity coupled with an increasing radiation burden that limits multiplexing. Despite high sensitivity, positron emission tomography and single-photon emission tomography have disadvantages when applied to multiplex molecular imaging due to poor spatial resolution, signal cross talk and increasing radiation dose. In contrast, MRI is non-toxic, displays good spatial resolution but poor sensitivity. Preclinical techniques include near-infrared fluorescence (NIRF), which provides good spatial resolution and sensitivity; however, multiplexing with NIRF is limited, due to photobleaching and spectral overlap. Fourier transform infrared spectroscopy and Raman spectroscopy are label-free techniques that detect molecules based on the vibrations of chemical bonds. Both techniques offer fast acquisition times with Raman showing superior spatial resolution. Raman signals are inherently weak; however, leading to the development of surface-enhanced Raman spectroscopy (SERS) that offers greatly increased sensitivity due to using metallic nanoparticles that can be functionalised with biomolecules targeted against plaque ligands while offering high multiplexing potential. This asset combined with high spatial resolution makes SERS an exciting prospect as a diagnostic tool. The ongoing refinements of SERS technologies such as deep tissue imaging and portable systems making SERS a realistic prospect for translation to the clinic.

Spiers Memorial Lecture : Surface-enhanced Raman spectroscopy: from single particle/molecule spectroscopy to ångstrom-scale spatial resolution and femtosecond time resolution

2017 ◽  
Vol 205 ◽  
pp. 9-30 ◽  
Author(s):  
Anne-Isabelle Henry ◽  
Tyler W. Ueltschi ◽  
Michael O. McAnally ◽  
Richard P. Van Duyne
Keyword(s):  
Raman Spectroscopy ◽  
Spatial Resolution ◽  
Single Molecule ◽  
Time Resolution ◽  
Glucose Sensor ◽  
Surface Enhanced Raman Spectroscopy ◽  
Memorial Lecture ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Four decades on, surface-enhanced Raman spectroscopy (SERS) continues to be a vibrant field of research that is growing (approximately) exponentially in scope and applicability while pushing at the ultimate limits of sensitivity, spatial resolution, and time resolution. This introductory paper discusses some aspects related to all four of the themes for this Faraday Discussion. First, the wavelength-scanned SERS excitation spectroscopy (WS-SERES) of single nanosphere oligomers (viz., dimers, trimers, etc.), the distance dependence of SERS, the magnitude of the chemical enhancement mechanism, and the progress toward developing surface-enhanced femtosecond stimulated Raman spectroscopy (SE-FSRS) are discussed. Second, our efforts to develop a continuous, minimally invasive, in vivo glucose sensor based on SERS are highlighted. Third, some aspects of our recent work in single molecule SERS and the translation of that effort to ångstrom-scale spatial resolution in ultrahigh vacuum tip-enhanced Raman spectroscopy (UHV-TERS) and single molecule electrochemistry using electrochemical (EC)-TERS will be presented. Finally, we provide an overview of analytical SERS with our viewpoints on SERS substrates, approaches to address the analyte generality problem (i.e. target molecules that do not spontaneously adsorb and/or have Raman cross sections <10−29 cm2 sr−1), SERS for catalysis, and deep UV-SERS.

scholarly journals Molecular imaging with surface-enhanced Raman spectroscopy nanoparticle reporters

MRS Bulletin ◽  
2013 ◽  
Vol 38 (8) ◽  
pp. 625-630 ◽  
Author(s):  
Jesse V. Jokerst ◽  
Christoph Pohling ◽  
Sanjiv S. Gambhir
Keyword(s):  
Raman Spectroscopy ◽  
Molecular Imaging ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Image Position

Abstract

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