scholarly journals In vivo Imaging-Guided Nanoplatform for Tumor Targeting Delivery and Combined Chemo-, Gene- and Photothermal Therapy

Theranostics ◽  
2018 ◽  
Vol 8 (20) ◽  
pp. 5662-5675 ◽  
Author(s):  
Cheng Li ◽  
Xiao-Quan Yang ◽  
Ming-Zhen Zhang ◽  
Yuan-Yang Song ◽  
Kai Cheng ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Targeting Delivery

scholarly journals Development of theranostic dual-layered Au-liposome for effective tumor targeting and photothermal therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Miyeon Jeon ◽  
Gaeun Kim ◽  
Wooseung Lee ◽  
Seungki Baek ◽  
Han Na Jung ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Therapeutic Strategy ◽  
Tumor Growth Inhibition ◽  
Positron Emission ◽  
Anti Cancer ◽  
Good Biocompatibility ◽  
Targeting Ability

Abstract Background Photothermal therapy (PTT) is an emerging anti-cancer therapeutic strategy that generates hyperthermia to ablate cancer cells under laser irradiation. Gold (Au) coated liposome (AL) was reported as an effective PTT agent with good biocompatibility and excretory property. However, exposed Au components on liposomes can cause instability in vivo and difficulty in further functionalization. Results Herein, we developed a theranostic dual-layered nanomaterial by adding liposomal layer to AL (LAL), followed by attaching polyethylene glycol (PEG) and radiolabeling. Functionalization with PEG improves the in vivo stability of LAL, and radioisotope labeling enables in vivo imaging of LAL. Functionalized LAL is stable in physiological conditions, and 64Cu labeled LAL (64Cu-LAL) shows a sufficient blood circulation property and an effective tumor targeting ability of 16.4%ID g−1 from in vivo positron emission tomography (PET) imaging. Also, intravenously injected LAL shows higher tumor targeting, temperature elevation in vivo, and better PTT effect in orthotopic breast cancer mouse model compared to AL. The tumor growth inhibition rate of LAL was 3.9-fold higher than AL. Conclusion Based on these high stability, in vivo imaging ability, and tumor targeting efficiency, LAL could be a promising theranostic PTT agent. Graphic Abstract

Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging

2016 ◽  
Vol 8 (7) ◽  
pp. 4378-4384 ◽  
Author(s):  
Dawei Jiang ◽  
Yanhong Sun ◽  
Jiang Li ◽  
Qian Li ◽  
Min Lv ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Tumor Targeting ◽  
Dna Nanostructures ◽  
Dual Modality

scholarly journals Targeted Delivery Prodigiosin to Choriocarcinoma by Peptide-Guided Dendrigraft Poly-l-lysines Nanoparticles

2019 ◽  
Vol 20 (21) ◽  
pp. 5458 ◽  
Author(s):  
Kai Zhao ◽  
Dan Li ◽  
Guogang Cheng ◽  
Baozhen Zhang ◽  
Jinyu Han ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Tumor Targeting ◽  
Caspase 3 ◽  
Slow Release ◽  
Normal Cells ◽  
Binding Peptide ◽  
P53 Signaling ◽  
Targeting Delivery ◽  
P53 Signaling Pathway

The available and effective therapeutic means to treat choriocarcinoma is seriously lacking, mainly due to the toxic effects caused by chemotherapy and radiotherapy. Accordingly, we developed a method for targeting delivery of chemotherapeutical drugs only to cancer cells, not normal cells, in vivo, by using a synthetic placental chondroitin sulfate (CSA)-binding peptide (plCSA-BP) derived from malarial protein VAR2CSA. A 28 amino acids placental CSA-binding peptide (plCSA-BP) from the VAR2CSA was synthesized as a guiding peptide for tumor-targeting delivery, dendrigraft poly-L-lysines (DGL) was modified with plCSA-BP and served as a novel targeted delivery carrier. Choriocarcinoma was selected to test the effect of targeted delivery carrier, and prodigiosin isolated from Serratia marcescens subsp. lawsoniana was selected as a chemotherapeutical drug and encapsulated in the DGL modified by the plCSA-BP nanoparticles (DGL/CSA-PNPs). DGL/CSA-PNPs had a sustained slow-release feature at pH 7.4, which could specifically bind to the JEG3 cells and exhibited better anticancer activity than that of the controls. The DGL/CSA-PNPs induced the apoptosis of JEG3 cells through caspase-3 and the P53 signaling pathway. DGL/CSA-PNPs can be used as an excellent targeted delivery carrier for anticancer drugs, and the prodigiosin could be an alternative chemotherapeutical drug for choriocarcinoma.

Activatable UCL/CT/MR-Enhanced in vivo Imaging-Guided Radiotherapy and Photothermal Therapy

2022 ◽  
Author(s):  
Jianming Ni ◽  
Huiting Xu ◽  
Yanqi Zhong ◽  
Yongping Zhou ◽  
Shudong Hu
Keyword(s):  
Tumor Microenvironment ◽  
Therapeutic Effect ◽  
In Vivo Imaging ◽  
Photothermal Therapy ◽  
Copper Sulphide ◽  
Hypoxic Tumor

Although sophisticated radiotherapy (RT) technology has been widely applied in clinical oncotherapy, unsatisfactory therapeutic effect resulted by hypoxic tumor microenvironment and complications are still prevalent. Herein, copper sulphide nanoparticles (CuS...

Multi-layered tumor-targeting photothermal-doxorubicin releasing nanotubes eradicate tumors in vivo with negligible systemic toxicity

Nanoscale ◽  
2018 ◽  
Vol 10 (18) ◽  
pp. 8536-8546 ◽  
Author(s):  
Daquan Wang ◽  
Lingjie Meng ◽  
Zhaofu Fei ◽  
Chen Hou ◽  
Jiangang Long ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Single Walled Carbon Nanotubes ◽  
Layer By Layer ◽  
Assembly Process ◽  
Small Molecule Drug ◽  
Walled Carbon Nanotubes ◽  
Layer Assembly

Multi-layered single-walled carbon nanotubes, termed SWNT@BSA@Au-S-PEG-FA@DOX, which integrate photothermal therapy with small molecule drug delivery, were prepared using a facile layer-by-layer assembly process.

Gold nanorods as a theranostic platform for in vitro and in vivo imaging and photothermal therapy of inflammatory macrophages

Nanoscale ◽  
2015 ◽  
Vol 7 (33) ◽  
pp. 13991-14001 ◽  
Author(s):  
Jinbao Qin ◽  
Zhiyou Peng ◽  
Bo Li ◽  
Kaichuang Ye ◽  
Yuxin Zhang ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
In Vivo Imaging ◽  
Photothermal Therapy ◽  
Au Nanorods ◽  
Associated Diseases ◽  
Inflammatory Macrophages

This study shows that Au nanorods are a promising theranostic platform for the diagnosis and photothermal therapy of inflammation associated diseases.

RGD-Conjugated Dendrimer-Modified Gold Nanorods for in Vivo Tumor Targeting and Photothermal Therapy

2009 ◽  
Vol 7 (1) ◽  
pp. 94-104 ◽  
Author(s):  
Zhiming Li ◽  
Peng Huang ◽  
Xuejun Zhang ◽  
Jing Lin ◽  
Sen Yang ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Tumor Targeting

A folic acid conjugated polyethylenimine-modified PEGylated nanographene loaded photosensitizer: photodynamic therapy and toxicity studies in vitro and in vivo

2016 ◽  
Vol 4 (12) ◽  
pp. 2190-2198 ◽  
Author(s):  
Yi-Ping Zeng ◽  
Sheng-Lin Luo ◽  
Zhang-You Yang ◽  
Jia-Wei Huang ◽  
Hong Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Folic Acid ◽  
Delivery System ◽  
Tumor Targeting ◽  
Therapy Efficacy ◽  
Toxicity Studies ◽  
Targeting Delivery

A novel nanographene-based tumor-targeting delivery system has high photodynamic therapy efficacy with no obvious toxicity and could potentially be utilized in biomedicine.

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