scholarly journals Ethyl acetate subfractions from ethanol extracts of fermented oats (Avena sativa L.) exert anti-cancer properties in vitro and in vivo through G2/M and S Phase arrest and apoptosis

2021 ◽  
Vol 12 (7) ◽  
pp. 1853-1866
Author(s):  
Nanhai Zhang ◽  
Liang Zhao ◽  
Shengbao Cai ◽  
Xiang Zeng ◽  
Wei Wu ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Avena Sativa ◽  
S Phase ◽  
Phase Arrest ◽  
Anti Cancer ◽  
S Phase Arrest ◽  
Ethanol Extracts

scholarly journals Phytoestrogen Bakuchiol Exhibits In Vitro and In Vivo Anti-breast Cancer Effects by Inducing S Phase Arrest and Apoptosis

2016 ◽  
Vol 7 ◽  
Author(s):  
Li Li ◽  
Xueping Chen ◽  
Chi C. Liu ◽  
Lai S. Lee ◽  
Cornelia Man ◽  
...  
Keyword(s):  
Breast Cancer ◽  
S Phase ◽  
Phase Arrest ◽  
S Phase Arrest

scholarly journals Ganoderma tsugaeInduces S Phase Arrest and Apoptosis in Doxorubicin-Resistant Lung Adenocarcinoma H23/0.3 Cells via Modulation of the PI3K/Akt Signaling Pathway

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Yang-Hao Yu ◽  
Han-Peng Kuo ◽  
Hui-Hsia Hsieh ◽  
Jhy-Wei Li ◽  
Wu-Huei Hsu ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
S Phase ◽  
Akt Signaling Pathway ◽  
Suppression Effect ◽  
Phase Arrest ◽  
S Phase Arrest

Ganoderma tsugae(GT) is a traditional Chinese medicine that exhibits significant antitumor activities against many types of cancer. This study investigated the molecular mechanism by which GT suppresses the growth of doxorubicin-resistant lung adenocarcinoma H23/0.3 cells. Our results reveal that GT inhibits the viability of H23/0.3 cellsin vitroandin vivoand sensitizes the growth suppression effect of doxorubicin on H23/0.3 cells. The data also show that GT induces S phase arrest by interfering with the protein expression of cyclin A, cyclin E, CDK2, and CDC25A. Furthermore, GT induces cellular apoptosis via induction of a mitochondria/caspase pathway. In addition, we also demonstrate that the suppression of cell proliferation by GT is through down-regulation of the PI3K/Akt signaling pathway. In conclusion, this study suggests that GT may be a useful adjuvant therapeutic agent in the treatment of lung cancer.

scholarly journals Selenocystine inhibits JEG-3 cell growth in vitro and in vivo by triggering oxidative damage-mediated S-phase arrest and apoptosis

2018 ◽  
Vol 14 (7) ◽  
pp. 1540 ◽  
Author(s):  
Zhigang Wei ◽  
Ming Zhao ◽  
Yajun Hou ◽  
Xiaoting Fu ◽  
Dawei Li ◽  
...  
Keyword(s):  
Cell Growth ◽  
Oxidative Damage ◽  
S Phase ◽  
Phase Arrest ◽  
S Phase Arrest

Water-soluble oxoglaucine-Y(iii), Dy(iii) complexes: in vitro and in vivo anticancer activities by triggering DNA damage, leading to S phase arrest and apoptosis

2015 ◽  
Vol 44 (25) ◽  
pp. 11408-11419 ◽  
Author(s):  
Jian-Hua Wei ◽  
Zhen-Feng Chen ◽  
Jiao-Lan Qin ◽  
Yan-Cheng Liu ◽  
Zhu-Quan Li ◽  
...  
Keyword(s):  
Dna Damage ◽  
Anticancer Activity ◽  
S Phase ◽  
Water Soluble ◽  
Anticancer Activities ◽  
Phase Arrest ◽  
S Phase Arrest

The complexes exhibited considerable in vitro and in vivo anticancer activity, and higher safety than ciplatin.

scholarly journals Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo

2019 ◽  
Vol 20 (13) ◽  
pp. 3197 ◽  
Author(s):  
Takanori Matsui ◽  
Taiga Chiyo ◽  
Hideki Kobara ◽  
Shintaro Fujihara ◽  
Koji Fujita ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Tumor Growth ◽  
S Phase ◽  
Phase Arrest ◽  
S Phase Arrest

Esophageal squamous cell carcinoma (ESCC) is the most common primary esophageal malignancy. Telmisartan, an angiotensin II type 1 (AT1) receptor blocker (ARB) and a widely used antihypertensive, has been shown to inhibit proliferation of various cancer types. This study evaluated the effects of telmisartan on human ESCC cell proliferation in vitro and in vivo and sought to identify the microRNAs (miRNAs) involved in these antitumor effects. We examined the effects of telmisartan on three human ESCC cell lines (KYSE150, KYSE180, and KYSE850). Telmisartan inhibited proliferation of these three cell lines by inducing S-phase arrest, which was accompanied by decreased expression of cyclin A2, cyclin-dependent kinase 2, and other cell cycle-related proteins. Additionally, telmisartan reduced levels of phosphorylated ErbB3 and thrombospondin-1 in KYSE180 cells. Furthermore, expression of miRNAs was remarkably altered by telmisartan in vitro. Telmisartan also inhibited tumor growth in vivo in a xenograft mouse model. In conclusion, telmisartan inhibited cell proliferation and tumor growth in ESCC cells by inducing cell-cycle arrest.

scholarly journals Copper complexes as prospective anticancer agents: in vitro and in vivo evaluation, selective targeting of cancer cells by DNA damage and S phase arrest

RSC Advances ◽  
2018 ◽  
Vol 8 (30) ◽  
pp. 16973-16990 ◽  
Author(s):  
Dharmasivam Mahendiran ◽  
Sethu Amuthakala ◽  
Nattamai S. P. Bhuvanesh ◽  
Raju Senthil Kumar ◽  
Aziz Kalilur Rahiman
Keyword(s):  
Dna Damage ◽  
Anticancer Agents ◽  
Copper Complexes ◽  
S Phase ◽  
In Vivo Evaluation ◽  
Phase Arrest ◽  
Selective Targeting ◽  
S Phase Arrest

The thiosemicarbazone-based copper(i) complexes causing S phase arrest and apoptosis involving the mitochondrial controlled pathway has been investigated.

scholarly journals Betulinic Acid Induces ROS-Dependent Apoptosis and S-Phase Arrest by Inhibiting the NF-κB Pathway in Human Multiple Myeloma

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
Min Shen ◽  
Yiqiang Hu ◽  
Yan Yang ◽  
Lanlan Wang ◽  
Xin Yang ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Betulinic Acid ◽  
Redox Homeostasis ◽  
Xenograft Model ◽  
S Phase ◽  
Phase Arrest ◽  
S Phase Arrest ◽  
Human Multiple Myeloma

Betulinic acid (BA), as a prospective natural compound, shows outstanding antitumor bioactivities against many solid malignancies. However, its mechanism against multiple myeloma (MM) remains elusive. Herein, for the first time, we studied the antitumor activity of BA against MM both in vivo and in vitro. We showed that BA mediated cytotoxicity in MM cells through apoptosis, S-phase arrest, mitochondrial membrane potential (MMP) collapse, and overwhelming reactive oxygen species (ROS) accumulation. Moreover, when the ROS scavenger N-acetyl cysteine (NAC) effectively abated elevated ROS, the BA-induced apoptosis was partially reversed. Our results revealed that BA-mediated ROS overproduction played a pivotal role in anticancer activity. Molecularly, we found that BA resulted in marked inhibition of the aberrantly activated NF-κB pathway in MM. As demonstrated by using the NF-κB pathway-specific activator TNF-α and the inhibitor BAY 11-7082, BA-mediated inhibition of the NF-κB pathway directly promoted the overproduction of ROS and, ultimately, cell death. Furthermore, BA also exerted enormous tumor-inhibitory effects via repressing proliferation and inhibiting the NF-κB pathway in our xenograft model. Overall, by blocking the NF-κB pathway that breaks redox homeostasis, BA, as a potent NF-κB inhibitor, is a promising therapeutic alternative for MM.

Sign in / Sign up

Export Citation Format

Share Document