scholarly journals Phytoestrogen Bakuchiol Exhibits In Vitro and In Vivo Anti-breast Cancer Effects by Inducing S Phase Arrest and Apoptosis

2016 ◽  
Vol 7 ◽  
Author(s):  
Li Li ◽  
Xueping Chen ◽  
Chi C. Liu ◽  
Lai S. Lee ◽  
Cornelia Man ◽  
...  
Keyword(s):  
Breast Cancer ◽  
S Phase ◽  
Phase Arrest ◽  
S Phase Arrest

scholarly journals Ganoderma tsugaeInduces S Phase Arrest and Apoptosis in Doxorubicin-Resistant Lung Adenocarcinoma H23/0.3 Cells via Modulation of the PI3K/Akt Signaling Pathway

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Yang-Hao Yu ◽  
Han-Peng Kuo ◽  
Hui-Hsia Hsieh ◽  
Jhy-Wei Li ◽  
Wu-Huei Hsu ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
S Phase ◽  
Akt Signaling Pathway ◽  
Suppression Effect ◽  
Phase Arrest ◽  
S Phase Arrest

Ganoderma tsugae(GT) is a traditional Chinese medicine that exhibits significant antitumor activities against many types of cancer. This study investigated the molecular mechanism by which GT suppresses the growth of doxorubicin-resistant lung adenocarcinoma H23/0.3 cells. Our results reveal that GT inhibits the viability of H23/0.3 cellsin vitroandin vivoand sensitizes the growth suppression effect of doxorubicin on H23/0.3 cells. The data also show that GT induces S phase arrest by interfering with the protein expression of cyclin A, cyclin E, CDK2, and CDC25A. Furthermore, GT induces cellular apoptosis via induction of a mitochondria/caspase pathway. In addition, we also demonstrate that the suppression of cell proliferation by GT is through down-regulation of the PI3K/Akt signaling pathway. In conclusion, this study suggests that GT may be a useful adjuvant therapeutic agent in the treatment of lung cancer.

scholarly journals Selenocystine inhibits JEG-3 cell growth in vitro and in vivo by triggering oxidative damage-mediated S-phase arrest and apoptosis

2018 ◽  
Vol 14 (7) ◽  
pp. 1540 ◽  
Author(s):  
Zhigang Wei ◽  
Ming Zhao ◽  
Yajun Hou ◽  
Xiaoting Fu ◽  
Dawei Li ◽  
...  
Keyword(s):  
Cell Growth ◽  
Oxidative Damage ◽  
S Phase ◽  
Phase Arrest ◽  
S Phase Arrest

Water-soluble oxoglaucine-Y(iii), Dy(iii) complexes: in vitro and in vivo anticancer activities by triggering DNA damage, leading to S phase arrest and apoptosis

2015 ◽  
Vol 44 (25) ◽  
pp. 11408-11419 ◽  
Author(s):  
Jian-Hua Wei ◽  
Zhen-Feng Chen ◽  
Jiao-Lan Qin ◽  
Yan-Cheng Liu ◽  
Zhu-Quan Li ◽  
...  
Keyword(s):  
Dna Damage ◽  
Anticancer Activity ◽  
S Phase ◽  
Water Soluble ◽  
Anticancer Activities ◽  
Phase Arrest ◽  
S Phase Arrest

The complexes exhibited considerable in vitro and in vivo anticancer activity, and higher safety than ciplatin.

scholarly journals Gallotannin Imposes S Phase Arrest in Breast Cancer Cells and Suppresses the Growth of Triple-Negative Tumors In Vivo

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e92853 ◽  
Author(s):  
Tiejun Zhao ◽  
Qiang Sun ◽  
Sonia V. del Rincon ◽  
Amanda Lovato ◽  
Maud Marques ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
S Phase ◽  
Phase Arrest ◽  
S Phase Arrest

scholarly journals Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo

2019 ◽  
Vol 20 (13) ◽  
pp. 3197 ◽  
Author(s):  
Takanori Matsui ◽  
Taiga Chiyo ◽  
Hideki Kobara ◽  
Shintaro Fujihara ◽  
Koji Fujita ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Tumor Growth ◽  
S Phase ◽  
Phase Arrest ◽  
S Phase Arrest

Esophageal squamous cell carcinoma (ESCC) is the most common primary esophageal malignancy. Telmisartan, an angiotensin II type 1 (AT1) receptor blocker (ARB) and a widely used antihypertensive, has been shown to inhibit proliferation of various cancer types. This study evaluated the effects of telmisartan on human ESCC cell proliferation in vitro and in vivo and sought to identify the microRNAs (miRNAs) involved in these antitumor effects. We examined the effects of telmisartan on three human ESCC cell lines (KYSE150, KYSE180, and KYSE850). Telmisartan inhibited proliferation of these three cell lines by inducing S-phase arrest, which was accompanied by decreased expression of cyclin A2, cyclin-dependent kinase 2, and other cell cycle-related proteins. Additionally, telmisartan reduced levels of phosphorylated ErbB3 and thrombospondin-1 in KYSE180 cells. Furthermore, expression of miRNAs was remarkably altered by telmisartan in vitro. Telmisartan also inhibited tumor growth in vivo in a xenograft mouse model. In conclusion, telmisartan inhibited cell proliferation and tumor growth in ESCC cells by inducing cell-cycle arrest.

scholarly journals Copper complexes as prospective anticancer agents: in vitro and in vivo evaluation, selective targeting of cancer cells by DNA damage and S phase arrest

RSC Advances ◽  
2018 ◽  
Vol 8 (30) ◽  
pp. 16973-16990 ◽  
Author(s):  
Dharmasivam Mahendiran ◽  
Sethu Amuthakala ◽  
Nattamai S. P. Bhuvanesh ◽  
Raju Senthil Kumar ◽  
Aziz Kalilur Rahiman
Keyword(s):  
Dna Damage ◽  
Anticancer Agents ◽  
Copper Complexes ◽  
S Phase ◽  
In Vivo Evaluation ◽  
Phase Arrest ◽  
Selective Targeting ◽  
S Phase Arrest

The thiosemicarbazone-based copper(i) complexes causing S phase arrest and apoptosis involving the mitochondrial controlled pathway has been investigated.

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