scholarly journals Effects of perioperative Eicosapentaenoic acid-enriched oral nutritional supplement on lean body mass after total gastrectomy for gastric cancer

2019 ◽  
Vol 10 (5) ◽  
pp. 1070-1076 ◽  
Author(s):  
Toru Aoyama ◽  
Takaki Yoshikawa ◽  
Satoshi Ida ◽  
Haruhiko Cho ◽  
Kentaro Sakamaki ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Eicosapentaenoic Acid ◽  
Total Gastrectomy ◽  
Lean Body Mass ◽  
Body Mass ◽  
Nutritional Supplement ◽  
Oral Nutritional Supplement

Risk factors for loss of lean body mass after gastrectomy for gastric cancer.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 79-79
Author(s):  
Toru Aoyama ◽  
Tsutomu Sato ◽  
Kenki Segami ◽  
Yukio Maezawa ◽  
Kazuki Kano ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Mass Loss ◽  
Total Gastrectomy ◽  
Lean Body Mass ◽  
Body Mass ◽  
Surgical Complications ◽  
Significant Risk ◽  
Cancer Center ◽  
Body Mass Loss

79 Background: Lean body mass loss after surgery, which decreases compliance of adjuvant chemotherapy, is frequently observed in gastric cancer patients who underwent gastrectomy for gastric cancer. However, the risk factors of lean body mass loss remain unclear. Methods: The present study retrospectively examined the patients who underwent curative gastrectomy for gastric cancer between June 2010 and March 2014 at Kanagawa Cancer Center. All patients received perioperative care of the enhanced recovery after surgery protocol. % Lean body mass loss was calculated by percentile of lean body mass at one month after surgery to preoperative lean body mass. Severe lean body mass loss was defined as % lean body mass loss over 5%. Risk factors for severe lean body mass loss were determined by both univariate and multivariate logistic regression analyses. Results: Four-hundred eighty five patients were examined. Median age was 67 years. Operative procedure was total gastrectomy in 190 patients and distal gastrectomy in 295 patients. Surgical complications of grade 2 or more defined by Clavien-Dindo classification was observed in 78 patients including pancreatic fistula in 19, anastomotic leakage in 11 and abdominal abscess in 7. Mortality was observed in one patient. Both univariate and multivariate logistic analyses demonstrated that surgical complications (odds rate 3.576, p = 0.001), total gastrectomy (odds rate 2.522, p = 0.0001), and gender (odds rate 1.928, p = 0.001) were significant independent risk factors for severe lean body mass loss. Conclusions: Male, surgical complications, and total gastrectomy were significant risk factors for 5% of lean body mass loss at first month after gastrectomy. To maintain lean body mass after gastrectomy, the physician need careful attention for the patients who had these risk factors.

scholarly journals Baseline deficiency of the anti-inflammatory eicosapentaenoic acid in cell membranes worsens lean body mass wasting induced by inactivity

2017 ◽  
Vol 14 ◽  
pp. 36-41 ◽  
Author(s):  
Filippo Giorgio Di Girolamo ◽  
Francesco Agostini ◽  
Sara Mazzucco ◽  
Roberta Situlin ◽  
Filippo Mearelli ◽  
...  
Keyword(s):  
Eicosapentaenoic Acid ◽  
Lean Body Mass ◽  
Body Mass ◽  
Cell Membranes ◽  
Mass Wasting ◽  
Anti Inflammatory

Randomized trial effect of an oral nutritional supplement with eicosapentaenoic acid on nutritional and inflammatory parameters, response and toxicity to chemotherapy, quality of life, and survival in treatment-naive patients with advanced non-small lung cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e19594-e19594
Author(s):  
Karla Sanchez-Lara ◽  
Jenny Turcott ◽  
Eva Juarez ◽  
Martha de la Torre ◽  
Geraldine Villanueva ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Eicosapentaenoic Acid ◽  
Nutritional Supplement ◽  
Inflammatory Parameters ◽  
Oral Nutritional Supplement ◽  
Physical Scale ◽  
Nsclc Patients ◽  
Experimental Group

e19594 Background: Nutritional interventions have shown increased of energy intake but the effect of improvement in health related quality of life (HRQL) in non small cell lung cancer (NSCLC) patients is controversial. Eicosapentaenoic acid has been proposed to have anti-inflammatory, anticachectic and possibly could have antitumoral effects. Methods: Patients with advanced NSCLC naive to treatment were included and randomly assigned to receive diet and oral nutritional supplement enriched with EPA or only isocaloric diet. All patients received paclitaxel and cisplatin-carboplatin treatment. Weight, body composition measured with bioelectrical impedance analysis, dietary ingestion, inflammatory parameters and HRQL were assessed at baseline and after 1st and 2nd cycle. Response to chemotherapy and survival were evaluated. Results: Ninety-two patients were analyzed, (46 EPA, 46 control group). No basal differences between groups were found. Experimental group present significantly increased albumin levels, energy, proteins, lipids and carbohydrate intake, and reduced serum CPR, TNF-α and Neutrophyls/Lymphocytes index. Patients in experimental group presented minor prevalence of weight loss and increased 1.6 kg of lean body mass (LBM) compared with controls. In HRQL, experimental group presented an improvement in global and physical scale and anorexia, and regarding toxicity, fatigue and neuropathy diminished. There was no difference in response rate, progression free survival and overall survival between groups. Conclusions: EPA enriched supplementation provided a therapeutic advantage by increasing LBM and nutrients intake, improving HRQL, and reduce several toxicity parameters in NSCLC patients under chemotherapy. The study was registered with ClinicalTrials.gov, number NCT01048970.

scholarly journals Influence of eicosapentaenoic acid supplementation on lean body mass in cancer cachexia

2011 ◽  
Vol 105 (10) ◽  
pp. 1469-1473 ◽  
Author(s):  
R A Murphy ◽  
E Yeung ◽  
V C Mazurak ◽  
M Mourtzakis
Keyword(s):  
Eicosapentaenoic Acid ◽  
Lean Body Mass ◽  
Body Mass ◽  
Cancer Cachexia ◽  
Acid Supplementation

scholarly journals Laparoscopic Total Gastrectomy for Gastric Cancer: Does Body Mass Index Matter?

2021 ◽  
Vol 4 (5) ◽  
pp. 28-32
Author(s):  
Akile Zengin ◽  
Yusuf Murat Bağ ◽  
Mehmet Can Aydin ◽  
Kuntay Kaplan ◽  
Fatih Sumer ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Body Mass Index ◽  
Total Gastrectomy ◽  
Body Mass ◽  
Laparoscopic Total Gastrectomy

Loss of Lean Body Mass as an Independent Risk Factor for Continuation of S-1 Adjuvant Chemotherapy for Gastric Cancer

2014 ◽  
Vol 22 (8) ◽  
pp. 2560-2566 ◽  
Author(s):  
Toru Aoyama ◽  
Taiichi Kawabe ◽  
Hirohito Fujikawa ◽  
Tsutomu Hayashi ◽  
Takanobu Yamada ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Risk Factor ◽  
Adjuvant Chemotherapy ◽  
Lean Body Mass ◽  
Body Mass ◽  
Independent Risk Factor
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