scholarly journals MAP2K1 Mutation in Colorectal Cancer Patients: Therapeutic Challenge Using Patient-Derived Tumor Cell Lines

2017 ◽  
Vol 8 (12) ◽  
pp. 2263-2268 ◽  
Author(s):  
J. E. Kim ◽  
K.K. Kim ◽  
S. Y. Kim ◽  
J. Lee ◽  
S. H. Park ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Cell ◽  
Cancer Patients ◽  
Cell Lines ◽  
Tumor Cell Lines ◽  
Therapeutic Challenge ◽  
Colorectal Cancer Patients

scholarly journals NCOA4-RET fusion in colorectal cancer: Therapeutic challenge using patient-derived tumor cell lines

2018 ◽  
Vol 9 (17) ◽  
pp. 3032-3037 ◽  
Author(s):  
Sun Young Kim ◽  
Seiyoon Oh Oh ◽  
Kyung Kim ◽  
Jeeyun Lee ◽  
SoYoung Kang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Cell ◽  
Cell Lines ◽  
Tumor Cell Lines ◽  
Therapeutic Challenge

scholarly journals Tumor-specific CD8+ T lymphocytes derived from the peripheral blood of prostate cancer patients byin vitro stimulation with autologous tumor cell lines

2002 ◽  
Vol 98 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Franck Housseau ◽  
Daniel A. Langer ◽  
Samuel D. Oberholtzer ◽  
Anitha Moorthy ◽  
Hyam I. Levitsky ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
T Lymphocytes ◽  
Tumor Cell ◽  
Cancer Patients ◽  
Cell Lines ◽  
Peripheral Blood ◽  
Autologous Tumor Cell ◽  
Autologous Tumor ◽  
Tumor Cell Lines ◽  
Cd8 T Lymphocytes

Cytostasis of tumor cell lines by granulocytes from cancer patients and normal human donors

1981 ◽  
Vol 28 (2) ◽  
pp. 119-124 ◽  
Author(s):  
S. Korec ◽  
R. B. Herberman ◽  
G. B. Cannon ◽  
J. Reid ◽  
J. A. Braatz
Keyword(s):  
Tumor Cell ◽  
Cancer Patients ◽  
Cell Lines ◽  
Tumor Cell Lines ◽  
Normal Human

58 Mutational Analysis of Circulating Tumor Cell Subpopulations From Colorectal Cancer Patients and Correlation With Primary Tumor Tissue

2015 ◽  
Vol 148 (4) ◽  
pp. S-17
Author(s):  
Maria Gazouli ◽  
Anna Lyberopoulou ◽  
Penelope Bouziotis ◽  
Apostolos Papalois ◽  
Nikolaos I. Nikiteas ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Cell ◽  
Cancer Patients ◽  
Primary Tumor ◽  
Tumor Tissue ◽  
Mutational Analysis ◽  
Circulating Tumor Cell ◽  
Cell Subpopulations ◽  
Colorectal Cancer Patients

Clinical significance of serum angiopoietin-like protein 2 in colorectal cancer patients.

2014 ◽  
Vol 32 (3_suppl) ◽  
pp. 417-417
Author(s):  
Takahito Kitajima ◽  
Yuji Toiyama ◽  
Tadanobu Shimura ◽  
Shozo Ide ◽  
Hiroki Imaoka ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Cell ◽  
Cancer Patients ◽  
Clinical Significance ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Staining Intensity ◽  
High Serum ◽  
Highly Correlated ◽  
Colorectal Cancer Patients

417 Background: Angiopoietin-like protein 2 (ANGPTL2) is a secreted protein belonging to the angiopoietin family. It has been reported to act as a causative mediator of chronic inflammation and metabolic abnormalities. ANGPTL2 increases inflammatory carcinogenesis in several cancers, and its expression in tumor cells is highly correlated with the frequency of tumor cell metastasis through increased tumor angiogenesis and tumor cell epithelial-to-mesenchymal transitions. However, to our own knowledge, clinical significance of serum ANGPTL2 in cancer patients remains unknown. The aim of this study was to quantify serum ANGPTL2 level using ELISA, and to evaluate its clinical and prognostic significance in patients with colorectal cancer (CRC). Methods: We quantified serum ANGPTL2 levels from 194 CRC patients and normal 48 controls (NC) by ELISA. Next, we investigated ANGPTL2 expression in matched CRC tissues (n=194) by immunohistochemistry (IHC) to identify the source of circulating ANGPTL2. The IHC score of ANGPTL2 was determined on the basis of both staining intensity and the percentage of positive cells. Results: Serum ANGPTL2 levels were significantly higher in CRC than in NC (p<0.01) and gradually increased according to TNM stage progression. Serum ANGPTL2 levels discriminated CRC from NC with high accuracy (AUC=0.837). High serum ANGPTL2 was significantly associated with larger tumor size (p=0.03), undifferentiated adenocarcinoma (p=0.03), advanced T stage (p<0.01), peritoneal metastasis (p<0.01). In addition, Kaplan–Meier curves revealed that high serum ANGPTL2 were significantly associated with poor disease free survival (p=0.01) and overall survival (p=0.03). Interestingly, ANGPTL2 levels in serum from CRC patients closely correlated with IHC scores of cytoplasmic ANGPTL2 expression in matched CRC tissues (r=0.14, p=0.03). Conclusions: Serum ANGPTL2, which might be derived from primary CRC tumor, has strong potential to serve as a noninvasive biomarker for CRC diagnosis and prognosis.

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