scholarly journals Hypoxia-inducible factor-1 alpha Correlates with Tumor-Associated Macrophages Infiltration, Influences Survival of Gastric Cancer Patients

2017 ◽  
Vol 8 (10) ◽  
pp. 1818-1825 ◽  
Author(s):  
Wei-jie Zhang ◽  
Cheng Chen ◽  
Zhi-hua Zhou ◽  
Shan-ting Gao ◽  
Teong Jin Tee ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Hypoxia Inducible Factor ◽  
Tumor Associated Macrophages ◽  
Hypoxia Inducible Factor 1 ◽  
Gastric Cancer Patients

scholarly journals Tumor-Associated Macrophages and Mast Cells Positive to Tryptase Are Correlated with Angiogenesis in Surgically-Treated Gastric Cancer Patients

2018 ◽  
Vol 19 (4) ◽  
pp. 1176 ◽  
Author(s):  
Giuseppe Sammarco ◽  
Cosmo Damiano Gadaleta ◽  
Valeria Zuccalà ◽  
Emre Albayrak ◽  
Rosa Patruno ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Mast Cells ◽  
Cancer Patients ◽  
Tumor Associated Macrophages ◽  
Gastric Cancer Patients

scholarly journals Extracellular vesicles shed from gastric cancer mediate protumor macrophage differentiation

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Atene Ito ◽  
Shunsuke Kagawa ◽  
Shuichi Sakamoto ◽  
Kazuya Kuwada ◽  
Hiroki Kajioka ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Ascitic Fluid ◽  
Extracellular Vesicles ◽  
Peritoneal Cavity ◽  
Peritoneal Dissemination ◽  
Tumor Associated Macrophages ◽  
Gastric Cancer Cells ◽  
Gastric Cancer Patients

Abstract Background Peritoneal dissemination often develops in gastric cancer. Tumor-associated macrophages (TAMs) are present in the peritoneal cavity of gastric cancer patients with peritoneal dissemination, facilitating tumor progression. However, the mechanism by which macrophages differentiate into tumor-associated macrophages in the peritoneal cavity is not well understood. In this study, the interplay between gastric cancer-derived extracellular vesicles (EVs) and macrophages was investigated. Methods The association between macrophages and EVs in peritoneal ascitic fluid of gastric cancer patients, or from gastric cancer cell lines was examined, and their roles in differentiation of macrophages and potentiation of the malignancy of gastric cancer were further explored. Results Immunofluorescent assays of the ascitic fluid showed that M2 macrophages were predominant along with the cancer cells in the peritoneal cavity. EVs purified from gastric cancer cells, as well as malignant ascitic fluid, differentiated peripheral blood mononuclear cell-derived macrophages into the M2-like phenotype, which was demonstrated by their morphology and expression of CD163/206. The macrophages differentiated by gastric cancer-derived EVs promoted the migration ability of gastric cancer cells, and the EVs carried STAT3 protein. Conclusion EVs derived from gastric cancer play a role by affecting macrophage phenotypes, suggesting that this may be a part of the underlying mechanism that forms the intraperitoneal cancer microenvironment.

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