scholarly journals The Prognostic Value of Circulating Cell-Free DNA in Colorectal Cancer: A Meta-Analysis

2016 ◽  
Vol 7 (9) ◽  
pp. 1105-1113 ◽  
Author(s):  
Shiva Basnet ◽  
Zhen-yu Zhang ◽  
Wen-qiang Liao ◽  
Shu-heng Li ◽  
Ping-shu Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Cell Free Dna ◽  
Free Dna ◽  
Circulating Cell Free Dna

scholarly journals Circulating cell free DNA as the diagnostic marker for colorectal cancer: a systematic review and meta-analysis

Oncotarget ◽  
2018 ◽  
Vol 9 (36) ◽  
pp. 24514-24524 ◽  
Author(s):  
Xin Wang ◽  
Xia-Qing Shi ◽  
Peng-Wei Zeng ◽  
Fong-Ming Mo ◽  
Zi-Hua Chen
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Diagnostic Marker ◽  
Meta Analysis ◽  
Cell Free Dna ◽  
Free Dna ◽  
Circulating Cell Free Dna

Prognostic value of circulating cell-free DNA in patients with pancreatic cancer: A systemic review and meta-analysis

Gene ◽  
2018 ◽  
Vol 679 ◽  
pp. 328-334 ◽  
Author(s):  
Linyan Chen ◽  
Yi Zhang ◽  
Yuan Cheng ◽  
Dan Zhang ◽  
Sha Zhu ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Systemic Review ◽  
Cell Free Dna ◽  
Free Dna ◽  
Circulating Cell Free Dna

Circulating cell-free DNA in plasma of colorectal cancer patients - A potential biomarker for tumor burden

2017 ◽  
Vol 26 (4) ◽  
pp. 395-401 ◽  
Author(s):  
Jagdeep Singh Bhangu ◽  
Hossein Taghizadeh ◽  
Tamara Braunschmid ◽  
Thomas Bachleitner-Hofmann ◽  
Christine Mannhalter
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Tumor Burden ◽  
Cell Free Dna ◽  
Free Dna ◽  
Potential Biomarker ◽  
Colorectal Cancer Patients ◽  
Circulating Cell Free Dna

scholarly journals Detection of Colorectal Cancer in Circulating Cell-Free DNA by Methylated CpG Tandem Amplification and Sequencing

2019 ◽  
Vol 65 (7) ◽  
pp. 916-926 ◽  
Author(s):  
Jingyi Li ◽  
Xin Zhou ◽  
Xiaomeng Liu ◽  
Jie Ren ◽  
Jilian Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Early Stage ◽  
Plasma Samples ◽  
Dna Hypermethylation ◽  
Cell Free Dna ◽  
Noncancerous Tissue ◽  
Clinical Sensitivity ◽  
Free Dna ◽  
A Genome ◽  
Circulating Cell Free Dna

Abstract BACKGROUND Aberrant DNA hypermethylation of CpG islands occurs frequently throughout the genome in human colorectal cancer (CRC). A genome-wide DNA hypermethylation analysis technique using circulating cell-free DNA (cfDNA) is attractive for the noninvasive early detection of CRC and discrimination between CRC and other cancer types. METHODS We applied the methylated CpG tandem amplification and sequencing (MCTA-Seq) method, with a fully methylated molecules algorithm, to plasma samples from patients with CRC (n = 147) and controls (n = 136), as well as cancer and adjacent noncancerous tissue samples (n = 66). We also comparatively analyzed plasma samples from patients with hepatocellular carcinoma (HCC; n = 36). RESULTS Dozens of DNA hypermethylation markers including known (e.g., SEPT9 and IKZF1) and novel (e.g., EMBP1, KCNQ5, CHST11, APBB1IP, and TJP2) genes were identified for effectively detecting CRC in cfDNA. A panel of 80 markers discriminated early-stage CRC patients and controls with a clinical sensitivity of 74% and clinical specificity of 90%. Patients with early-stage CRC and HCC could be discriminated at clinical sensitivities of approximately 70% by another panel of 128 markers. CONCLUSIONS MCTA-Seq is a promising method for the noninvasive detection of CRC.

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