scholarly journals Age‐stratified reference intervals unlock the clinical potential of circulating cell‐free DNA as a biomarker of poor outcome for healthy individuals and patients with colorectal cancer

2020 ◽  
Author(s):  
Mai‐Britt Worm Ørntoft ◽  
Sarah Østrup Jensen ◽  
Nadia Øgaard ◽  
Tenna Vesterman Henriksen ◽  
Linnea Ferm ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Reference Intervals ◽  
Healthy Individuals ◽  
Cell Free Dna ◽  
Poor Outcome ◽  
Free Dna ◽  
Clinical Potential ◽  
Circulating Cell Free Dna

Circulating cell-free DNA in plasma of colorectal cancer patients - A potential biomarker for tumor burden

2017 ◽  
Vol 26 (4) ◽  
pp. 395-401 ◽  
Author(s):  
Jagdeep Singh Bhangu ◽  
Hossein Taghizadeh ◽  
Tamara Braunschmid ◽  
Thomas Bachleitner-Hofmann ◽  
Christine Mannhalter
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Tumor Burden ◽  
Cell Free Dna ◽  
Free Dna ◽  
Potential Biomarker ◽  
Colorectal Cancer Patients ◽  
Circulating Cell Free Dna

scholarly journals Detection of Colorectal Cancer in Circulating Cell-Free DNA by Methylated CpG Tandem Amplification and Sequencing

2019 ◽  
Vol 65 (7) ◽  
pp. 916-926 ◽  
Author(s):  
Jingyi Li ◽  
Xin Zhou ◽  
Xiaomeng Liu ◽  
Jie Ren ◽  
Jilian Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Early Stage ◽  
Plasma Samples ◽  
Dna Hypermethylation ◽  
Cell Free Dna ◽  
Noncancerous Tissue ◽  
Clinical Sensitivity ◽  
Free Dna ◽  
A Genome ◽  
Circulating Cell Free Dna

Abstract BACKGROUND Aberrant DNA hypermethylation of CpG islands occurs frequently throughout the genome in human colorectal cancer (CRC). A genome-wide DNA hypermethylation analysis technique using circulating cell-free DNA (cfDNA) is attractive for the noninvasive early detection of CRC and discrimination between CRC and other cancer types. METHODS We applied the methylated CpG tandem amplification and sequencing (MCTA-Seq) method, with a fully methylated molecules algorithm, to plasma samples from patients with CRC (n = 147) and controls (n = 136), as well as cancer and adjacent noncancerous tissue samples (n = 66). We also comparatively analyzed plasma samples from patients with hepatocellular carcinoma (HCC; n = 36). RESULTS Dozens of DNA hypermethylation markers including known (e.g., SEPT9 and IKZF1) and novel (e.g., EMBP1, KCNQ5, CHST11, APBB1IP, and TJP2) genes were identified for effectively detecting CRC in cfDNA. A panel of 80 markers discriminated early-stage CRC patients and controls with a clinical sensitivity of 74% and clinical specificity of 90%. Patients with early-stage CRC and HCC could be discriminated at clinical sensitivities of approximately 70% by another panel of 128 markers. CONCLUSIONS MCTA-Seq is a promising method for the noninvasive detection of CRC.

scholarly journals A new approach to epigenome-wide discovery of non-invasive methylation biomarkers for colorectal cancer screening in circulating cell-free DNA using pooled samples

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
María Gallardo-Gómez ◽  
Sebastian Moran ◽  
María Páez de la Cadena ◽  
Vicenta Soledad Martínez-Zorzano ◽  
Francisco Javier Rodríguez-Berrocal ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Colorectal Cancer Screening ◽  
Cell Free Dna ◽  
New Approach ◽  
Non Invasive ◽  
Free Dna ◽  
Pooled Samples ◽  
Circulating Cell Free Dna

Abstract 5233: Prediction and response evaluation of EGFR blockade for colorectal cancer by using circulating cell-free DNA

2015 ◽  
Author(s):  
Takuma Iwai ◽  
Takeshi Yamada ◽  
Hatato Kan ◽  
Michihiro Koizumi ◽  
Seiichi Shinji ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Response Evaluation ◽  
Cell Free Dna ◽  
Free Dna ◽  
Circulating Cell Free Dna

scholarly journals Treatment monitoring in metastatic colorectal cancer patients by quantification and KRAS genotyping of circulating cell-free DNA

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0174308 ◽  
Author(s):  
Andreas W. Berger ◽  
Daniel Schwerdel ◽  
Hanna Welz ◽  
Ralf Marienfeld ◽  
Stefan A. Schmidt ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Cancer Patients ◽  
Treatment Monitoring ◽  
Cell Free Dna ◽  
Free Dna ◽  
Colorectal Cancer Patients ◽  
Circulating Cell Free Dna

scholarly journals Multi-marker analysis of circulating cell-free DNA toward personalized medicine for colorectal cancer

2014 ◽  
Vol 8 (5) ◽  
pp. 927-941 ◽  
Author(s):  
Florent Mouliere ◽  
Safia El Messaoudi ◽  
Dalong Pang ◽  
Anatoly Dritschilo ◽  
Alain R. Thierry
Keyword(s):  
Colorectal Cancer ◽  
Personalized Medicine ◽  
Cell Free Dna ◽  
Free Dna ◽  
Marker Analysis ◽  
Circulating Cell Free Dna
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