scholarly journals Local Antimicrobial Treatment in Orthopaedic Surgery

2017 ◽  
Vol 2 (1) ◽  
pp. 1-2
Author(s):  
Antonia F. Chen ◽  
Heinz Winkler
Keyword(s):  
Basic Science ◽  
Orthopaedic Surgery ◽  
Clinical Evidence ◽  
Joint Infection ◽  
Antimicrobial Treatment ◽  
Special Issue ◽  
Orthopaedic Surgeons ◽  
Bone And Joint Infection

Abstract. The purpose of this special issue of Journal of Bone and Joint Infection is to provide orthopaedic surgeons with basic science explanations as to how these local antimicrobials work, clinical evidence that supports these local treatments, and the role of these local treatments against biofilm.

scholarly journals Inflammation and Atherosclerosis

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1197
Author(s):  
Klaus Ley
Keyword(s):  
Clinical Trials ◽  
Animal Models ◽  
Basic Science ◽  
Translational Science ◽  
Special Issue

This 11-chapter Special Issue of Cells spans the gamut from basic science in mechanistic animal models to translational science to outcomes of clinical trials, all focused on the role of inflammation in atherosclerosis [...]

scholarly journals Safety of tedizolid as suppressive antimicrobial therapy for patients with complex implant-associated bone and joint infection due to multidrug-resistant Gram-positive pathogens: results from the TediSAT cohort study

2021 ◽  
Author(s):  
Tristan Ferry ◽  
Anne Conrad ◽  
Eric Senneville ◽  
Sandrine Roux ◽  
Céline Dupieux-Chabert ◽  
...  
Keyword(s):  
Adverse Event ◽  
Cohort Study ◽  
Joint Infection ◽  
Multidrug Resistant ◽  
Antimicrobial Treatment ◽  
Duration Of Treatment ◽  
Gram Positive ◽  
Serious Adverse Event ◽  
Bone And Joint Infection

Abstract A prospective cohort study was conducted to evaluate long-term safety of tedizolid as suppressive antimicrobial treatment in patients with implant-associated bone and joint infection caused by multidrug-resistant Gram-positive pathogens. Seventeen patients received tedizolid with a median duration of treatment of 6 months No patients developed a serious adverse event.

scholarly journals The Impact of the Multidisciplinary Team on the Management of Prosthetic Joint Infection in Trauma and Orthopaedic Surgery

2020 ◽  
Author(s):  
Nemandra A. Sandiford ◽  
Konrad Wronka
Keyword(s):  
Health Care Providers ◽  
Prosthetic Joint Infection ◽  
Orthopaedic Surgery ◽  
Joint Infection ◽  
Multidisciplinary Care ◽  
Care Providers ◽  
Prosthetic Joint ◽  
The Impact ◽  
Multi Disciplinary Team

Periprosthetic Joint Infection (PJI) is a devastating complication of the Total Joint Arthroplasty (TJA). It presents a great challenge for the clinician to diagnose and manage it appropriately, with significant morbidity for the patients and cost for health care providers. The purpose of this study is to review and examine the role of multi-disciplinary team (MDT) approach in diagnosis and management of prosthetic joint infection (PJI) and how this approach can influence outcomes. All published literature examining the role of multidisciplinary care in the management of PJI and the influence of this approach to the management and outcomes of patients with this diagnosis were included. Studies published in languages other than English were excluded. There is a paucity of data on the influence of multidisciplinary care on outcomes of the management of PJI. Evidence suggests that the MDT has important role in ensuring all factors in the management of this complex group are considered and best possible care is delivered. Multicentre randomised clinical trials are required to assess the influence of MDT’S on outcome as well as important questions around the structuring of these teams.

scholarly journals Controversy about the Role of Rifampin in Biofilm Infections: Is It Justified?

Antibiotics ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 165
Author(s):  
Nora Renz ◽  
Andrej Trampuz ◽  
Werner Zimmerli
Keyword(s):  
Clinical Evidence ◽  
Controlled Trial ◽  
Joint Infection ◽  
Current Data ◽  
Multiple Drug ◽  
Randomized Controlled ◽  
The Past ◽  
Prosthesis Retention ◽  
Rifampin Resistance

Rifampin is a potent antibiotic against staphylococcal implant-associated infections. In the absence of implants, current data suggest against the use of rifampin combinations. In the past decades, abundant preclinical and clinical evidence has accumulated supporting its role in biofilm-related infections.In the present article, experimental data from animal models of foreign-body infections and clinical trials are reviewed. The risk for emergence of rifampin resistance and multiple drug interactions are emphasized. A recent randomized controlled trial (RCT) showing no beneficial effect of rifampin in patients with acute staphylococcal periprosthetic joint infection treated with prosthesis retention is critically reviewed and data interpreted. Given the existing strong evidence demonstrating the benefit of rifampin, the conduction of an adequately powered RCT with appropriate definitions and interventions would probably not comply with ethical standards.

scholarly journals Special Issue “Recent Developments in Annexin Biology”

Cells ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 2477
Author(s):  
Ursula Rescher ◽  
Volker Gerke ◽  
Lina Hsiu Kim Lim ◽  
Jyoti K. Jaiswal
Keyword(s):  
Biomedical Research ◽  
Basic Science ◽  
Global Network ◽  
Cellular Organization ◽  
Special Issue ◽  
Recent Developments ◽  
Health And Disease ◽  
Over 40 Years ◽  
Initial Research

Discovered over 40 years ago, the annexin proteins were found to be a structurally conserved subgroup of Ca2+-binding proteins. While the initial research on annexins focused on their signature feature of Ca2+-dependent binding to membranes, over the years the biennial Annexin conference series has highlighted additional diversity in the functions attributed to the annexin family of proteins. The roles of these proteins now extend from basic science to biomedical research, and are being translated into the clinic. The research on annexins involves a global network of researchers, and the 10th biennial Annexin conference brought together over 80 researchers from ten European countries, USA, Brazil, Singapore, Japan and Australia for 3 days in September 2019. In this conference, the discussions focused on two distinct themes—the role of annexins in cellular organization and in health and disease. The articles published in this Special Issue cover these two main themes discussed at this conference, offering a glimpse into some of the notable findings in the field of annexin biology.

scholarly journals Emerging Roles of Dyslipidemia and Hyperglycemia in Diabetic Retinopathy: Molecular Mechanisms and Clinical Perspectives

2021 ◽  
Vol 12 ◽  
Author(s):  
Hussain Rao ◽  
Jonathan A. Jalali ◽  
Thomas P. Johnston ◽  
Peter Koulen
Keyword(s):  
Diabetic Retinopathy ◽  
Literature Review ◽  
Basic Science ◽  
Molecular Mechanisms ◽  
Clinical Evidence ◽  
Vision Loss ◽  
Science Research ◽  
Therapeutic Interventions ◽  
Research Subject

Diabetic retinopathy (DR) is a significant cause of vision loss and a research subject that is constantly being explored for new mechanisms of damage and potential therapeutic options. There are many mechanisms and pathways that provide numerous options for therapeutic interventions to halt disease progression. The purpose of the present literature review is to explore both basic science research and clinical research for proposed mechanisms of damage in diabetic retinopathy to understand the role of triglyceride and cholesterol dysmetabolism in DR progression. This review delineates mechanisms of damage secondary to triglyceride and cholesterol dysmetabolism vs. mechanisms secondary to diabetes to add clarity to the pathogenesis behind each proposed mechanism. We then analyze mechanisms utilized by both triglyceride and cholesterol dysmetabolism and diabetes to elucidate the synergistic, additive, and common mechanisms of damage in diabetic retinopathy. Gathering this research adds clarity to the role dyslipidemia has in DR and an evaluation of the current peer-reviewed basic science and clinical evidence provides a basis to discern new potential therapeutic targets.

Non-pharmacological Strategies Against Systemic Inflammation: Molecular Basis and Clinical Evidence

2020 ◽  
Vol 26 (22) ◽  
pp. 2620-2629 ◽  
Author(s):  
Rita Del Pinto ◽  
Davide Pietropaoli ◽  
Annalisa Monaco ◽  
Giovambattista Desideri ◽  
Claudio Ferri ◽  
...  
Keyword(s):  
Human Genome ◽  
Systemic Inflammation ◽  
Clinical Evidence ◽  
Metabolic Diseases ◽  
Lifestyle Changes ◽  
Common Denominator ◽  
Active Lifestyle ◽  
Systemic Impact ◽  
Public Health Strategies

Systemic inflammation is a common denominator to a variety of cardiovascular (CV) and non-CV diseases and relative risk factors, including hypertension and its control, metabolic diseases, rheumatic disorders, and those affecting the gastrointestinal tract. Besides medications, a non-pharmacological approach encompassing lifestyle changes and other complementary measures is mentioned in several updated guidelines on the management of these conditions. We performed an updated narrative review on the mechanisms behind the systemic impact of inflammation and the role of non-pharmacological, complementary measures centered on lowering systemic phlogosis for preserving or restoring a good global health. The central role of genetics in shaping the immune response is discussed in conjunction with that of the microbiome, highlighting the interdependence and mutual influences between the human genome and microbial integrity, diversity, and functions. Several plausible strategies to modulate inflammation and restore balanced crosstalk between the human genome and the microbiome are then recapitulated, including dietary measures, active lifestyle, and other potential approaches to manipulate the resident microbial community. To date, evidence from high-quality human studies is sparse to allow the unconditioned inclusion of understudied, though plausible solutions against inflammation into public health strategies for global wellness. This gap claims further focused, well-designed research targeted at unravelling the mechanisms behind future personalized medicine.

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