scholarly journals Intestinal and Hepatic Expression of Cytochrome P450s and mdr1a in Rats with Indomethacin-Induced Small Intestinal Ulcers

2014 ◽  
Vol 11 (12) ◽  
pp. 1208-1217 ◽  
Author(s):  
Shoji Kawauchi ◽  
Tsutomu Nakamura ◽  
Hiroyuki Yasui ◽  
Chikako Nishikawa ◽  
Ikuya Miki ◽  
...  
Keyword(s):  
Cytochrome P450s ◽  
Hepatic Expression ◽  
Small Intestinal ◽  
Intestinal Ulcers

Down-regulation of hepatic CYP3A1 expression in a rat model of indomethacin-induced small intestinal ulcers

2016 ◽  
Vol 37 (9) ◽  
pp. 522-532 ◽  
Author(s):  
Shoji Kawauchi ◽  
Tsutomu Nakamura ◽  
Sayo Horibe ◽  
Toshihito Tanahashi ◽  
Shigeto Mizuno ◽  
...  
Keyword(s):  
Rat Model ◽  
Down Regulation ◽  
Small Intestinal ◽  
Intestinal Ulcers

Registry Request: Multiple Small-Intestinal Ulcers and Malabsorption

Radiology ◽  
1973 ◽  
Vol 106 (1) ◽  
pp. 12-12
Author(s):  
Theodore M. Bayless
Keyword(s):  
Small Intestinal ◽  
Intestinal Ulcers

scholarly journals Small intestinal ulcers in hemophagocytic lymphohistiocytosis presenting as acute appendicitis

2014 ◽  
Vol 2 (6) ◽  
pp. 325-327
Author(s):  
Rachel Kassel ◽  
Jason O. Robertson ◽  
Vanderlene L. Kung ◽  
Frances V. White ◽  
Andrew S. Cluster ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Small Intestinal ◽  
Intestinal Ulcers

Tu1592 Clinical Course of Patients With Aspirin-Induced Small Intestinal Ulcers Detected by Capsule Endoscopy

2011 ◽  
Vol 73 (4) ◽  
pp. AB457
Author(s):  
Shunji Fujimori ◽  
Masahiro Toyoda ◽  
Yukiko Ensaka ◽  
Kotaro Maki ◽  
Yusuke Kasuga ◽  
...  
Keyword(s):  
Capsule Endoscopy ◽  
Clinical Course ◽  
Small Intestinal ◽  
Intestinal Ulcers

scholarly journals Video capsule endoscopy: Initial experience from a tertiary care center in Sri Lanka

2021 ◽  
Vol 12 (11) ◽  
pp. 40-44
Author(s):  
Dinesh Rangika Perera ◽  
Piyal Rangana ◽  
Sanjeewa Aryasingha
Keyword(s):  
Small Bowel ◽  
Sri Lanka ◽  
Capsule Endoscopy ◽  
Bowel Disease ◽  
Diagnostic Yield ◽  
Tertiary Care ◽  
Small Bowel Disease ◽  
Small Intestinal ◽  
Intestinal Ulcers ◽  
Small Bowel Bleeding

Background: Since its global introduction in 2000, capsule endoscopy (CE) has revolutionized the evaluation of small bowel disease. Aims and Objective: The aim of this study was to share our experience with CE including the findings and its diagnostic yield. Materials and Methods: A retrospective study was carried out at Colombo South Teaching Hospital of Sri Lanka. Data of patients who underwent CE from its initiation in 2017 until June 2020 were obtained from the hospital computer database. These included the patient demographics, indications for the study, quality of bowel preparation, and its findings. Results: The study included 54 patients with a mean age of 55 years. Mean gastric time and small bowel transit time were 52 and 272 min, respectively. Forty-five CE studies were done for the evaluation of small bowel bleeding and an abnormal study was found in 26 (57.78%) patients. Small intestinal ulcers and erosions were the most frequently found abnormality (n=16, 35.56%) followed by tumors (n=5, 11.11%). Active bleeding was evident in 14 (31.11%) patients. Overall diagnostic yield was higher in those with a history of overt bleeding (n=15, 71.43%) compared to occult bleeding (n=11, 45.83%). Most patients who were evaluated for abdominal pain and diarrhea had normal CE except for two who had small intestinal ulcers and subepithelial lesions. Only one case was complicated with capsule retention. Conclusion: CE is a useful investigation for the evaluation of small bowel disease, particularly in suspected small bowel bleeding. In contrast to western population, ulcers and erosions were the more frequently found abnormalities seen in local setting.

scholarly journals Traditional Herbal Medicine, Rikkunshito, Induces HSP60 and Enhances Cytoprotection of Small Intestinal Mucosal Cells as a Nontoxic Chaperone Inducer

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Kumiko Tamaki ◽  
Michiro Otaka ◽  
Tomoyoshi Shibuya ◽  
Naoto Sakamoto ◽  
Soh Yamamoto ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Immunoblot Analysis ◽  
Intestinal Cell ◽  
Traditional Herbal Medicine ◽  
Intestinal Cell Line ◽  
Mucosal Cells ◽  
Hsp60 Expression ◽  
Small Intestinal ◽  
Intestinal Ulcers

Increasing incidence of small intestinal ulcers associated with nonsteroidal anti-inflammatory drugs (NSAIDs) has become a topic with recent advances of endoscopic technology. However, the pathogenesis and therapy are not fully understood. The aim of this study is to examine the effect of Rikkunshito (TJ-43), a traditional herbal medicine, on expression of HSP60 and cytoprotective ability in small intestinal cell line (IEC-6). Effect of TJ-43 on HSP60 expression in IEC-6 cells was evaluated by immunoblot analysis. The effect of TJ-43 on cytoprotective abilities of IEC-6 cells against hydrogen peroxide or indomethacin was studied by MTT assay, LDH-release assay, caspase-8 activity, and TUNEL. HSP60 was significantly induced by TJ-43. Cell necrosis and apoptosis were significantly suppressed in IEC-6 cells pretreated by TJ-43 with overexpression of HSP60. Our results suggested that HSP60 induced by TJ-43 might play an important role in protecting small intestinal epithelial cells from apoptosis and necrosis in vitro.

Multiple small intestinal ulcers with SLCO2A1 and PLA2G4A mutation in a Chinese patient

2021 ◽  
Author(s):  
Kaidi Sun ◽  
Qijin He ◽  
Lanping Zhu ◽  
Gulisitan Abula ◽  
Jingwen Zhao ◽  
...  
Keyword(s):  
Chinese Patient ◽  
Small Intestinal ◽  
Intestinal Ulcers

scholarly journals The Detective Value of Magnetically Controlled Robotic Capsule Endoscopy in Patients With Suspected Small Intestinal Disease

2021 ◽  
Vol 8 ◽  
Author(s):  
Xiao-Yu Chen ◽  
Wei Da ◽  
Rui Liang ◽  
Hui-Ning Fan ◽  
You-Cai Yi ◽  
...  
Keyword(s):  
Capsule Endoscopy ◽  
Detection Rate ◽  
Endoscopic Examination ◽  
Intestinal Disease ◽  
Intestinal Bleeding ◽  
Small Intestinal Bleeding ◽  
Small Intestinal ◽  
Capsule Retention ◽  
Intestinal Ulcers ◽  
Small Intestinal Disease

Objective: To explore the detective value of magnetically controlled robotic capsule endoscopy (MCRCE) in patients with suspected small intestinal disease.Patients and Methods: In total, 1,802 patients with suspected small intestinal disease and negative gastroenteroscopy from Shanghai Jiao Tong University Affiliated Sixth People's Hospital were examined with MCRCE, and the data were collected for further analysis.Results: Among the 1,802 patients who were examined with MCRCE, 974 were diagnosed with small intestinal disease, reaching a positive detection rate of 54.1%. The five most common conditions that were detected include non-specific enteritis in 722 cases (40.1%), small intestinal ulcers in 87 cases (4.8%), abnormal small bowel evacuation in 45 cases (2.5%), small intestinal bleeding in 33 cases (1.8%), and small intestinal yellow spots in 31 cases (1.7%). The running time of the capsules in the small intestine ranged from 85–437 min, with an average of 210.24 ± 89.08 min. No complications, such as intestinal obstruction or capsule retention, were observed in all patients.Conclusion: MCRCE is a safe and non-invasive endoscopic examination with a highly accurate detection rate for small intestinal diseases.

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