Down-regulation of hepatic CYP3A1 expression in a rat model of indomethacin-induced small intestinal ulcers

2016 ◽  
Vol 37 (9) ◽  
pp. 522-532 ◽  
Author(s):  
Shoji Kawauchi ◽  
Tsutomu Nakamura ◽  
Sayo Horibe ◽  
Toshihito Tanahashi ◽  
Shigeto Mizuno ◽  
...  
Keyword(s):  
Rat Model ◽  
Down Regulation ◽  
Small Intestinal ◽  
Intestinal Ulcers

scholarly journals Evaluation of Small Intestinal Motility in a Rat Model of Irritable Bowel Syndrome

2021 ◽  
Author(s):  
Masamichi Sato ◽  
Takahiro Kudo ◽  
Nobuyasu Arai ◽  
Reiko Kyodo ◽  
Kenji Hosoi ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Small Intestine ◽  
Real Time ◽  
Rat Model ◽  
Intestinal Motility ◽  
Restraint Stress ◽  
Rat Models ◽  
Small Intestinal Motility ◽  
Small Intestinal ◽  
Irritable Bowel

Abstract Background: The correlation between small intestinal motility alteration and irritable bowel syndrome (IBS) is not well evaluated. Aims: To assess the small intestinal and colonic transits in an IBS rat model with restraint stress and determine the role of small intestinal motility in the IBS pathophysiology.Methods: Restraint stress was utilized to make adolescent IBS rat models that were evaluated for clinical symptoms, including stool frequency and diarrhea. The small intestinal motility and transit rate were also evaluated. The amounts of mRNA encoding corticotropin-releasing hormone, mast cell, and serotonin (5-Hydroxytryptamine; 5-HT) receptor 3a were quantified using real-time polymerase chain reaction (PCR); the 5-HT expression was evaluated using immunostaining.Results: Restraint stress significantly increased the number of fecal pellet outputs, stool water content, and small intestinal motility in the IBS rat models. There was no difference in real-time PCR results, but immunostaining analysis revealed that 5-HT expression in the small intestine was significantly increased in the IBS rat models.Conclusions: In the adolescent rat model of IBS with restraint stress, we observed an increase in small intestinal and colonic motility. In the small intestine, enhanced 5-HT secretion in the distal portion may be involved in increasing the small intestinal motility.

Hippocampal DHCR24 down regulation in a rat model of streptozotocin-induced cognitive decline

2015 ◽  
Vol 587 ◽  
pp. 107-112 ◽  
Author(s):  
Soheila Hosseinzadeh ◽  
Maryam Zahmatkesh ◽  
Mansour Heidari ◽  
Gholam-Reza Hassanzadeh ◽  
Morteza Karimian ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Rat Model ◽  
Down Regulation

Composite sponges from sheep decellularized small intestinal submucosa for treatment of diabetic wounds

2020 ◽  
pp. 088532822096389
Author(s):  
Gamze Kara Magden ◽  
Cigdem Vural ◽  
Busra Yaprak Bayrak ◽  
Candan Yilmaz Ozdogan ◽  
Halime Kenar
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
Rat Model ◽  
Small Intestinal Submucosa ◽  
Diabetic Rat ◽  
Control Group ◽  
Significant Difference ◽  
Small Intestinal ◽  
Intestinal Submucosa ◽  
Diabetic Rat Model

Despite the fast development of technology in the world, diabetic foot wounds cause deaths and massive economical losses. Diabetes comes first among the reasons of non traumatic foot amputations. To reduce the healing time of these fast progressing wounds, effective wound dressings are in high demand. In our study, sheep small intestinal submucosa (SIS) based biocompatible sponges were prepared after SIS decellularization and their wound healing potential was investigated on full thickness skin defects in a diabetic rat model. The decellularized SIS membranes had no cytotoxic effects on human fibroblasts and supported capillary formation by HUVECs in a fibroblast-HUVEC co-culture. Glutaraldehyde crosslinked sponges of three different compositions were prepared to test in a diabetic rat model: gelatin (GS), gelatin: hyaluronic acid (GS:HA) and gelatin: hyaluronic acid: SIS (GS:HA:SIS). The GS:HA:SIS sponges underwent a 24.8 ± 5.4% weight loss in a 7-day in vitro erosion test. All sponges had a similar Young’s modulus under compression but GS:HA:SIS had the highest (5.00 ± 0.04 kPa). Statistical analyses of histopathological results of a 12-day in vivo experiment revealed no significant difference among the control, GS, GS:HA, and GS:HA:SIS transplanted groups in terms of granulation tissue thickness, collagen deposition, capillary vessel formation, and foreign body reaction (P > 0.05). On the other hand, in the GS:HA:SIS transplanted group 80% of the animals had a complete epidermal regeneration and this was significantly different than the control group (30%, P < 0.05). Preclinical studies revealed that the ECM of sheep small intestinal submucosa can be used as an effective biomaterial in diabetic wound healing.

Registry Request: Multiple Small-Intestinal Ulcers and Malabsorption

Radiology ◽  
1973 ◽  
Vol 106 (1) ◽  
pp. 12-12
Author(s):  
Theodore M. Bayless
Keyword(s):  
Small Intestinal ◽  
Intestinal Ulcers

Small Intestinal Submucosa in Abdominal Wall Repair after TRAM Flap Harvesting in a Rat Model

2003 ◽  
Vol 112 (2) ◽  
pp. 565-570 ◽  
Author(s):  
Feng Zhang ◽  
Jian Zhang ◽  
Shuying Lin ◽  
Tanya Oswald ◽  
William Sones ◽  
...  
Keyword(s):  
Abdominal Wall ◽  
Rat Model ◽  
Small Intestinal Submucosa ◽  
Tram Flap ◽  
Abdominal Wall Repair ◽  
Small Intestinal ◽  
Intestinal Submucosa

scholarly journals Small intestinal ulcers in hemophagocytic lymphohistiocytosis presenting as acute appendicitis

2014 ◽  
Vol 2 (6) ◽  
pp. 325-327
Author(s):  
Rachel Kassel ◽  
Jason O. Robertson ◽  
Vanderlene L. Kung ◽  
Frances V. White ◽  
Andrew S. Cluster ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Small Intestinal ◽  
Intestinal Ulcers
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