scholarly journals Expression, Regulation and Function of MicroRNAs in Multiple Sclerosis

2014 ◽  
Vol 11 (8) ◽  
pp. 810-818 ◽  
Author(s):  
Xinting Ma ◽  
Juhua Zhou ◽  
Yin Zhong ◽  
Linlin Jiang ◽  
Ping Mu ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Expression Regulation ◽  
And Function

Effects of Neurodynamic Interventions on Pain Sensitivity and Function in Patients with Multiple Sclerosis: A Randomized Clinical Trial

Physiotherapy ◽  
2021 ◽  
Author(s):  
Juan de Dios Pérez-Bruzón ◽  
César Fernández-de-las-Peñas ◽  
Joshua A. Cleland ◽  
Gustavo Plaza-Manzano ◽  
Ricardo Ortega-Santiago
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Pain Sensitivity ◽  
And Function

scholarly journals Extracellular vesicles (exosomes and ectosomes) play key roles in the pathology of brain diseases

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Jacopo Meldolesi
Keyword(s):  
Multiple Sclerosis ◽  
Extracellular Vesicles ◽  
Brain Diseases ◽  
Target Cells ◽  
Surface Binding ◽  
Cells Of Origin ◽  
Relapsing Remitting ◽  
And Function ◽  
The Brain

AbstractLast century, neurons and glial cells were mostly believed to play distinct functions, relevant for the brain. Progressively, however, it became clear that neurons, astrocytes and microglia co-operate intensely with each other by release/binding of signaling factors, direct surface binding and generation/release of extracellular vesicles, the exosomes and ectosomes, called together vesicles in this abstract. The present review is focused on these vesicles, fundamental in various brain diseases. Their properties are extraordinary. The specificity of their membrane governs their fusion with distinct target cells, variable depending on the state and specificity of their cells of origin and target. Result of vesicle fusion is the discharge of their cargos into the cytoplasm of target cells. Cargos are composed of critical molecules, from proteins (various nature and function) to nucleotides (especially miRNAs), playing critical roles in immune and neurodegenerative diseases. Among immune diseases is multiple sclerosis, affected by extensive dysregulation of co-trafficking neural and glial vesicles, with distinct miRNAs inducing severe or reducing effects. The vesicle-dependent differences between progressive and relapsing-remitting forms of the disease are relevant for clinical developments. In Alzheimer’s disease the vesicles can affect the brain by changing their generation and inducing co-release of effective proteins, such Aβ and tau, from neurons and astrocytes. Specific miRNAs can delay the long-term development of the disease. Upon their traffic through the blood-brainbarrier, vesicles of various origin reach fluids where they are essential for the identification of biomarkers, important for diagnostic and therapeutic innovations, critical for the future of many brain patients.

Dimethyl fumarate–associated transient bone marrow oedema syndrome

2018 ◽  
Vol 25 (6) ◽  
pp. 876-879 ◽  
Author(s):  
James Triplett ◽  
Srimathy Vijayan ◽  
Richard Prince ◽  
Allan Kermode
Keyword(s):  
Multiple Sclerosis ◽  
Bone Marrow ◽  
Dimethyl Fumarate ◽  
Symptomatic Improvement ◽  
Bone Marrow Oedema ◽  
Related Factor ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
And Function ◽  
Relapsing Remitting Multiple Sclerosis

Background: Dimethyl fumarate (DMF) is a commonly used and effective treatment for relapsing and remitting multiple sclerosis. Its use results in impairment of the transcription factor nuclear factor erythroid-derived 2 (E2)-related factor (Nrf2), which is involved in both immunomodulation and bone health. DMF has not previously been reported to cause bone marrow complications, though other fumarates including tenofovir have. The mechanism of fumarate-associated bone toxicity remains unclear with altered osteoblastic gene expression and function suggested. Methods: We present a case of a 54-year-old female with relapsing remitting multiple sclerosis (RRMS) treated for 30 months with DMF who developed relapsing atraumatic lower limb bone pain. Results: Serial imaging revealed multifocal areas of bone marrow oedema and trabecular fractures. The patient was diagnosed with transient bone marrow oedema syndrome. Management consisted of cessation of therapy and treatment with the pro-osteobalstic agent denosumab. Conclusion: In this instance of DMF-associated bone marrow oedema, cessation of DMF and treatment with denosumab resulted in symptomatic improvement. DMF therapy may potentially result in bone marrow oedema due to inhibition of common upstream signalling pathways, including the Nrf2 signalling pathway.

Personal, health and function, and career maintenance factors as determinants of quality of life among employed people with multiple sclerosis

Work ◽  
2020 ◽  
Vol 67 (1) ◽  
pp. 81-94 ◽  
Author(s):  
Phillip Rumrill ◽  
Jian Li ◽  
David Strauser ◽  
Richard T. Roessler ◽  
Malachy Bishop ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Multiple Regression Model ◽  
Future Research ◽  
Personal Health ◽  
Washington Dc ◽  
Perceived Quality Of Life ◽  
National Multiple Sclerosis Society ◽  
And Function

BACKGROUND: Multiple sclerosis (MS) is an intrusive disease that significantly affects labor force participation. OBJECTIVE: This study examined the extent to which factors at the personal, health and function, and environmental/career maintenance levels contribute to the predictability power for quality of life among employed people with MS. METHOD: Participants consisted of 523 members of nine National Multiple Sclerosis Society chapters representing 21 states and Washington, DC. These individuals were employed at the time of the survey, and they were primarily middle age (average age of 48 years) and Caucasian (74%). RESULTS: The final hierarchical multiple regression model explained 54 percent of the variability in participants’ quality of life scores, although none of the hypothesized personal/demographic predictors were significant. Participants who perceived better overall health and lower levels of stress, who experienced less severe cognitive and mobility-related MS symptoms, and who expressed stronger job-person matches and higher levels of job satisfaction reported higher quality of life scores than did other participants. CONCLUSIONS: The findings underscore the complexity involved in predicting perceived quality of life among employed people with MS. Implications of these findings for future research and clinical practice are discussed.

OR-05 SEX DIFFERENCES IN VASCULAR STRUCTURE AND FUNCTION IN INDIVIDUALS WITH MULTIPLE SCLEROSIS AND HEALTHY CONTROLS

2016 ◽  
Vol 16 (C) ◽  
pp. 102
Author(s):  
Thessa Hilgenkamp ◽  
Garett Griffith ◽  
Robert W. Motl ◽  
Tracy Baynard ◽  
Bo Fernhall
Keyword(s):  
Multiple Sclerosis ◽  
Sex Differences ◽  
Structure And Function ◽  
Healthy Controls ◽  
Vascular Structure ◽  
And Function

scholarly journals FLT-3 expression and function on microglia in multiple sclerosis

2010 ◽  
Vol 89 (2) ◽  
pp. 109-116 ◽  
Author(s):  
Cynthia A. DeBoy ◽  
Horea Rus ◽  
Cosmin Tegla ◽  
Cornelia Cudrici ◽  
Melina V. Jones ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
And Function
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