scholarly journals Effect of 5-azacytidine (5-aza) on UCP2 expression in human liver and colon cancer cells

2021 ◽  
Vol 18 (10) ◽  
pp. 2176-2186
Author(s):  
Dae-Yeon Kim ◽  
Hee-Tae Cheong ◽  
Chang-Six Ra ◽  
Kazuhiro Kimura ◽  
Bae Dong Jung
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Liver ◽  
Colon Cancer Cells ◽  
Ucp2 Expression

scholarly journals Oleocanthal exerts antitumor effects on human liver and colon cancer cells through ROS generation

2017 ◽  
Vol 51 (2) ◽  
pp. 533-544 ◽  
Author(s):  
Antonella Cusimano ◽  
Daniele Balasus ◽  
Antonina Azzolina ◽  
Giuseppa Augello ◽  
Maria R. Emma ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Liver ◽  
Ros Generation ◽  
Colon Cancer Cells ◽  
Antitumor Effects

scholarly journals Methionine Adenosyltransferase 2B–GIT1 Complex Serves as a Scaffold to Regulate Ras/Raf/MEK1/2 Activity in Human Liver and Colon Cancer Cells

2015 ◽  
Vol 185 (4) ◽  
pp. 1135-1144 ◽  
Author(s):  
Hui Peng ◽  
Tony W.H. Li ◽  
Heping Yang ◽  
Mary P. Moyer ◽  
Jose M. Mato ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Liver ◽  
Methionine Adenosyltransferase ◽  
Colon Cancer Cells

Leptin is a growth factor for human colon cancer cells

2001 ◽  
Vol 120 (5) ◽  
pp. A493-A493
Author(s):  
J HARDWICK ◽  
G VANDENBRINK ◽  
S VANDEVENTER ◽  
M PEPPELENBOSCH
Keyword(s):  
Colon Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

Silencing of a death associated protein kinase as a pro-survival factor in colon cancer cells

Endoscopy ◽  
2005 ◽  
Vol 37 (05) ◽  
Author(s):  
GA Doherty ◽  
SM Byrne ◽  
SC Austin ◽  
GM Scully ◽  
EW Kay ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Protein Kinase ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Survival Factor ◽  
Death Associated Protein Kinase

Cytotoxic Effect of the Combination of Gemcitabine and Atorvastatin Loaded in Microemulsion on the HCT116 Colon Cancer Cells

2017 ◽  
Vol 9 (2) ◽  
Author(s):  
Mayson H. Alkhatib ◽  
Dalal Al-Saedi ◽  
Wadiah S. Backer
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Therapeutic Potential ◽  
Morphological Changes ◽  
In Vitro Study ◽  
Colon Cancer Cells ◽  
Apoptosis Detection ◽  
Hct116 Cells

The combination of anticancer drugs in nanoparticles has great potential as a promising strategy to maximize efficacies by eradicating resistant, reduce the dosage of the drug and minimize toxicities on the normal cells. Gemcitabine (GEM), a nucleoside analogue, and atorvastatin (ATV), a cholesterol lowering agent, have shown anticancer effect with some limitations. The objective of this in vitro study was to evaluate the antitumor activity of the combination therapy of GEM and ATVencapsulated in a microemulsion (ME) formulation in the HCT116 colon cancer cells. The cytotoxicity and efficacy of the formulation were assessed by the 3- (4,5dimethylthiazole-2-yl)-2,5-diphyneltetrazolium bromide (MTT) assay. The mechanism of cell death was examined by observing the morphological changes of treated cells under light microscope, identifying apoptosis by using the ApopNexin apoptosis detection kit, and viewing the morphological changes in the chromatin structure stained with 4′,6-diamidino-2-phenylindole (DAPI) under the inverted fluorescence microscope. It has been found that reducing the concentration of GEM loaded on ME (GEM-ME) from 5μM to 1.67μM by combining it with 3.33μM of ATV in a ME formulation (GEM/2ATV-ME) has preserved the strong cytotoxicity of GEM-ME against HCT116 cells. The current study proved that formulating GEM with ATV in ME has improved the therapeutic potential of GEM and ATV as anticancer drugs.

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