scholarly journals PDLSCs Regulate Angiogenesis of Periodontal Ligaments via VEGF Transferred by Exosomes in Periodontitis

2020 ◽  
Vol 17 (5) ◽  
pp. 558-567 ◽  
Author(s):  
Zhang Zhang ◽  
Yi Shuai ◽  
Feng Zhou ◽  
Jikai Yin ◽  
Jiachen Hu ◽  
...  
Keyword(s):  
Periodontal Ligaments

scholarly journals Micro-Raman Spectroscopy for Monitoring Changes in Periodontal Ligaments and Gingival Crevicular Fluid

Sensors ◽  
2014 ◽  
Vol 14 (12) ◽  
pp. 22552-22563 ◽  
Author(s):  
Carlo Camerlingo ◽  
Fabrizia d'Apuzzo ◽  
Vincenzo Grassia ◽  
Letizia Perillo ◽  
Maria Lepore
Keyword(s):  
Raman Spectroscopy ◽  
Gingival Crevicular Fluid ◽  
Micro Raman Spectroscopy ◽  
Crevicular Fluid ◽  
Periodontal Ligaments

scholarly journals Stability of Mini-Screws Invading the Dental Roots and Their Impact on the Paradental Tissues in Beagles

2009 ◽  
Vol 79 (2) ◽  
pp. 248-255 ◽  
Author(s):  
Yoon-Goo Kang ◽  
Ji-Young Kim ◽  
Young-Jun Lee ◽  
Kyu-Rhim Chung ◽  
Young-Guk Park
Keyword(s):  
Failure Rate ◽  
Adult Male ◽  
Alveolar Bone ◽  
Healing Process ◽  
Beagle Dogs ◽  
Tissue Samples ◽  
Retention Period ◽  
The Stability ◽  
Original Configuration ◽  
Periodontal Ligaments

Abstract Objective: To examine the stability of mini-screws that invade a dental root by measuring the retention period/failure rate, and to illustrate their effects on paradental tissues. Materials and Methods: Three adult male beagle dogs received 48 orthodontic mini-screws. Half of the mini-screws were implanted to invade the roots, and the rest were placed in the middle of the alveolar bone. Half of the mini-screws were loaded immediately. The retention period of the mini-screws was documented. The dogs were euthanized after 8 weeks, and tissue samples were examined histologically. Results: The failure rate of the mini-screws that invaded the roots was 79.2%, and that of the mini-screws in the middle of the alveolar bone was 8.3%. The application of force had little effect on the failed mini-screws. Moderately injured roots were repaired with osteoid and/or cementoid tissues with normal periodontal ligaments, followed by recovery of the original configuration. Conclusion: Orthodontic mini-screws had a higher failure rate when placed to invade the dental roots. However, minimally damaged dental roots do not adversely affect the healing process. (Angle Orthod. 2009:79; )

scholarly journals Biomaterial-Based Approaches for Regeneration of Periodontal Ligament and Cementum Using 3D Platforms

2019 ◽  
Vol 20 (18) ◽  
pp. 4364 ◽  
Author(s):  
Chan Ho Park
Keyword(s):  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Periodontal Ligament ◽  
State Of The Art ◽  
Tooth Root ◽  
Tissue Formation ◽  
Periodontal Tissue ◽  
Periodontal Tissues ◽  
Root Surfaces ◽  
Periodontal Ligaments

Currently, various tissue engineering strategies have been developed for multiple tissue regeneration and integrative structure formations as well as single tissue formation in musculoskeletal complexes. In particular, the regeneration of periodontal tissues or tooth-supportive structures is still challenging to spatiotemporally compartmentalize PCL (poly-ε-caprolactone)-cementum constructs with micron-scaled interfaces, integrative tissue (or cementum) formations with optimal dimensions along the tooth-root surfaces, and specific orientations of engineered periodontal ligaments (PDLs). Here, we discuss current advanced approaches to spatiotemporally control PDL orientations with specific angulations and to regenerate cementum layers on the tooth-root surfaces with Sharpey’s fiber anchorages for state-of-the-art periodontal tissue engineering.

scholarly journals Intravenous bisphosphonate therapy does not thicken cementum or change periodontal ligaments of cancer patients

2017 ◽  
Vol 123 (5) ◽  
pp. 591-599 ◽  
Author(s):  
Mariana de Pauli Paglioni ◽  
Wagner Gomes Silva ◽  
Juliana Pereira ◽  
César Augusto Migliorati ◽  
Marcio Ajudarte Lopes ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Bisphosphonate Therapy ◽  
Intravenous Bisphosphonate ◽  
Periodontal Ligaments

scholarly journals Comparison of the Effects Caused by Three Different Mandibular Advancement Devices on the Periodontal Ligaments and Teeth for the Treatment of Osa: A Finite Element Model Study

2020 ◽  
Vol 10 (19) ◽  
pp. 6932
Author(s):  
Giovanni Bruno ◽  
Alberto de Stefani ◽  
Manila Caragiuli ◽  
Francesca Zalunardo ◽  
Alida Mazzoli ◽  
...  
Keyword(s):  
Finite Element ◽  
Fem Analysis ◽  
Element Model ◽  
3D Models ◽  
Mandibular Advancement ◽  
Connecting Rod ◽  
Displacement Vectors ◽  
Obstructive Sleep ◽  
Mandibular Advancement Devices ◽  
Periodontal Ligaments

AIM: The purpose of this study is to compare the stress effects developed on the periodontal ligaments and teeth by three different types of mandibular advancement devices (MADs) using a finite element method (FEM) analysis. Introduction: Obstructive sleep apnea (OSA) is a disease with a high prevalence and, in recent years, the use of MADs as an alternative or support treatment to the continuous positive airway pressure (CPAP) has spread. Their use finds relative contraindications in the case of partial edentulism and severe periodontal disease. Given the widespread of periodontal problems, it is essential to know the effects that these devices cause on the periodontal ligament of the teeth. Materials and methods: Starting from the computed tomography (CT) scan of a patient’s skull, 3D reconstructions of the maxilla and mandible were implemented. Three different MADs were prepared for the patient, then 3D scanned, and lastly, coupled with the 3D models of the jaws. The devices have two different mechanics: One has a front reverse connecting rod (OrthoapneaTM), and two have lateral propulsion (SomnodentTM and HerbstTM). A FEM analysis was performed to calculate the stress applied on periodontal ligaments, on every single tooth and the displacement vectors that are generated by applying an advancement force on the mandible. Results: HerbstTM and SomnodentTM devices present very similar stress values, mainly concentrated on lateral teeth, but in general, the forces are very mild and distributed. The maximum stresses values are 3.27 kPa on periodontal ligaments and 287 kPa on teeth for SomnodentTM and 3.56 kPa on periodontal ligaments and 302 kPa on teeth for HerbstTM. OrthoapneaTM has, instead, higher and concentrated stress values, especially in the anterior maxillary and mandibular area with 4.26 kPa and 600 kPa as maximum stress values, respectively, on periodontal ligaments and teeth. Conclusions: From the results, it is concluded that devices with a bilateral mechanism generate less and more distributed stress than an anterior connecting rod mechanism. Therefore, they may be advisable to patients with compromised periodontal conditions in the anterior area.

scholarly journals Histochemical examination on principal collagen fibers in periodontal ligaments of ascorbic acid-deficient ODS-od/od rats

Microscopy ◽  
2019 ◽  
Vol 68 (5) ◽  
pp. 349-358 ◽  
Author(s):  
Tomoka Hasegawa ◽  
Yukina Miyamoto-Takasaki ◽  
Miki Abe ◽  
Zixuan Qiu ◽  
Tomomaya Yamamoto ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Acid Solution ◽  
Collagen Fibers ◽  
Collagen Fibrils ◽  
Male Rats ◽  
Control Group ◽  
Ascorbic Acid Solution ◽  
Cathepsin H ◽  
Periodontal Ligaments

Abstract In this study, we aimed to clarify the role of ascorbic acid in collagen synthesis in periodontal ligaments using osteogenic disorder Shionogi (ODS)/ShiJcl-od/od rats lacking L-gulonolactone oxidase. These rats cannot synthesize ascorbic acid in vivo. Eight-week-old ODS/ShiJcl-od/od male rats were administered ascorbic acid solution at a concentration of 200 mg/dL (control group, n = 6) or ascorbic acid solution at concentration of 0.3 mg/dL (insufficient group, n = 12). Six rats of the insufficient group were then given with ascorbic acid solution at concentration of 200 mg/dL for additional 3 weeks (rescued group, n = 6), and then, their mandibles were histochemically examined. Consequently, the insufficient group specimens were seen to possess fewer collagen fibers, and silver impregnation revealed numerous fine, reticular fiber-like fibrils branching off from collagen in the periodontal ligaments. In control group, faint immunoreactivities for matrix metalloproteinase (MMP)2 and cathepsin H were seen in the periphery of blood vessels and throughout the ligament, respectively. In contrast, in the insufficient group, intense MMP2-immunoreactivity was observed to be associated with collagen fibrils in the periodontal ligaments, and cathepsin H-immunopositivity was seen in ligamentous cells. The rescued group showed abundant collagen fibers filling the periodontal ligament space. Under transmission electron microscopy, ligamentous fibroblasts incorporated collagen fibrils into tubular endosomes/lysosomes while simultaneously synthesizing collagen fibril bundles. Thus, ascorbic acid insufficiency affected the immunolocalization of cathepsin H and MMP2; however, ligamentous fibroblasts appear to possess the potential to synthesize collagen fibers when supplied with ascorbic acid.

Influence of teeth, alveoli, and periodontal ligaments on torsional rigidity in human mandibles

1992 ◽  
Vol 89 (1) ◽  
pp. 59-72 ◽  
Author(s):  
David J. Daegling ◽  
Matthew J. Ravosa ◽  
Kirk R. Johnson ◽  
William L. Hylander
Keyword(s):  
Torsional Rigidity ◽  
Periodontal Ligaments

Osteogenic differentiation of stem cells derived from human periodontal ligaments and pulp of human exfoliated deciduous teeth

2010 ◽  
Vol 340 (2) ◽  
pp. 323-333 ◽  
Author(s):  
Kiranmai Chadipiralla ◽  
Ji Min Yochim ◽  
Bindu Bahuleyan ◽  
Chun-Yuh Charles Huang ◽  
Franklin Garcia-Godoy ◽  
...  
Keyword(s):  
Stem Cells ◽  
Osteogenic Differentiation ◽  
Deciduous Teeth ◽  
Human Exfoliated Deciduous Teeth ◽  
Periodontal Ligaments
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