scholarly journals LncRNA SNHG6 promotes proliferation, invasion and migration in colorectal cancer cells by activating TGF-β/Smad signaling pathway via targeting UPF1 and inducing EMT via regulation of ZEB1

2019 ◽  
Vol 16 (1) ◽  
pp. 51-59 ◽  
Author(s):  
Xinke Wang ◽  
Qiuhua Lai ◽  
Juan He ◽  
Qingyuan Li ◽  
Jian Ding ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Smad Signaling ◽  
Invasion And Migration ◽  
Colorectal Cancer Cells ◽  
Smad Signaling Pathway ◽  
And Migration

scholarly journals LncRNA CRNDE Promoted Colorectal Cancer Cells Reisitance To Paclitaxel Through Wnt/β-Catenin Signaling Pathway

2021 ◽  
Author(s):  
Rui Ma ◽  
Chuan-yang Yu ◽  
Xiang Tao ◽  
Zhi Yang ◽  
Qi Huang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Signaling Pathway ◽  
Colorectal Neoplasia ◽  
Cancer Treatments ◽  
Sw620 Cell ◽  
Invasion And Migration ◽  
Over Expression ◽  
Colorectal Cancer Cells ◽  
Sw620 Cells ◽  
And Migration

Abstract Background The lncRNA colorectal neoplasia differentially expressed (lncRNA CRNDE) is commonly over-expressed in different human cancers and involved in different biological functions. Paclitaxel(PTX) is a tricyclic diterpenoid compound which often used as a natural anticancer drugs in cancer treatments. Although there have many research reports about the mechanisms of LncRNA involved in PTX treatment, there are no any research about lncRNA CRNDE and PTX resistance in colorectal cancer. The purpose of this study is to investigate the mechanisims of LncRNA CRNDE involving PTX resistance in colorectal cancer. Results We constructed lncRNA CRNDE over-expression vector and transfected it into SW620 cell. CCK8, Transwell experiments proved that over-expression of lnc CRNDE increased SW620 cells proliferation and invasion, while the si-CRNDE group was significantly decreased. over-expression CRNDE can significantly up-regulate β-catenin, c-myc, APC and Axin2 expression and affect the expression of cyclinD1 and CDK4 after treated with PTX. Conclusion lncRNA CRNDE promotes CRCs proliferation, invasion and migration. Over-expression of LncRNA CRNDE enhanced the reisitance of CRC to PTX through inhibition of Wnt/ β-catenin signaling pathway.

scholarly journals PEITC inhibits the invasion and migration of colorectal cancer cells by blocking TGF-β-induced EMT

2020 ◽  
Vol 130 ◽  
pp. 110743
Author(s):  
Jian Xiao ◽  
Ningning Zhou ◽  
Yin Li ◽  
Yunyun Xiao ◽  
Wei Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Invasion And Migration ◽  
Colorectal Cancer Cells ◽  
And Migration

scholarly journals FOXM1 promotes invasion and migration of colorectal cancer cells partially dependent on HSPA5 transactivation

Oncotarget ◽  
2016 ◽  
Vol 7 (18) ◽  
pp. 26480-26495 ◽  
Author(s):  
Xiaoyong Luo ◽  
Jinke Yao ◽  
Peipei Nie ◽  
Zhiyuan Yang ◽  
Hongbo Feng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Invasion And Migration ◽  
Colorectal Cancer Cells ◽  
And Migration
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