scholarly journals FOXM1 promotes invasion and migration of colorectal cancer cells partially dependent on HSPA5 transactivation

Oncotarget ◽  
2016 ◽  
Vol 7 (18) ◽  
pp. 26480-26495 ◽  
Author(s):  
Xiaoyong Luo ◽  
Jinke Yao ◽  
Peipei Nie ◽  
Zhiyuan Yang ◽  
Hongbo Feng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Invasion And Migration ◽  
Colorectal Cancer Cells ◽  
And Migration

scholarly journals PEITC inhibits the invasion and migration of colorectal cancer cells by blocking TGF-β-induced EMT

2020 ◽  
Vol 130 ◽  
pp. 110743
Author(s):  
Jian Xiao ◽  
Ningning Zhou ◽  
Yin Li ◽  
Yunyun Xiao ◽  
Wei Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Invasion And Migration ◽  
Colorectal Cancer Cells ◽  
And Migration

scholarly journals MicroRNA-490-3p inhibits migration and chemoresistance of colorectal cancer cells via targeting TNKS2

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jing Li ◽  
Rubing Mo ◽  
Linmei Zheng
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Target Genes ◽  
Chemotherapy Resistance ◽  
Luciferase Assay ◽  
Migration And Invasion ◽  
Invasion And Migration ◽  
Colorectal Cancer Cells ◽  
And Migration ◽  
Common Malignancy

Abstract Objective Colorectal cancer is one of the most common malignancy in the world. The oncogenesis of colorectal cancer is still not fully elucidated. It was reported that microRNA-490-3p (miR-490-3p) was closely related to the regulation of cancers. However, if miR-490-3p could also affect colorectal cancer and the specific mechanism remains unclear. Methods qRT-PCR was conducted to examine the expression of miR-490-3p. DIANA, miRDB, and TargetScan databases were used to identify target genes. LOVO and SW480 cells were transfected by miR-490-3p mimics and inhibitors. Transwell assay was used to measure cell invasion and migration. Cisplatin and fluorouracil were administered to investigate chemotherapy resistance. Western blot was used to measure TNKS2 protein expression. Binding sites were verified using the double luciferase assay. Results miR-490-3p expression was low in the colorectal cancer cells. The level of miR-490-3p was negatively correlated with cell migration and invasion of cancer cells. miR-490-3p could bind to TNKS2 mRNA 3′UTR directly. miR-490-3p can suppress cell viability and resistance to chemotherapy in colorectal cancer cells through targeting TNKS2. Conclusions miR-490-3p could affect colorectal cancer by targeting TNKS2. This study may provide a potential therapeutic target for colorectal cancer.

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