scholarly journals The Putative Metal Coordination Motif in the Endonuclease Domain of Human Parvovirus B19 NS1 Is Critical for NS1 Induced S Phase Arrest and DNA Damage

2012 ◽  
Vol 8 (1) ◽  
pp. 79-92 ◽  
Author(s):  
Violetta Kivovich ◽  
Leona Gilbert ◽  
Matti Vuento ◽  
Stanley J. Naides
Keyword(s):  
Dna Damage ◽  
Parvovirus B19 ◽  
S Phase ◽  
Metal Coordination ◽  
Human Parvovirus B19 ◽  
Phase Arrest ◽  
Endonuclease Domain ◽  
S Phase Arrest

scholarly journals GADD45a Regulates Olaquindox-Induced DNA Damage and S-Phase Arrest in Human Hepatoma G2 Cells via JNK/p38 Pathways

Molecules ◽  
2017 ◽  
Vol 22 (1) ◽  
pp. 124 ◽  
Author(s):  
Daowen Li ◽  
Chongshan Dai ◽  
Xiayun Yang ◽  
Bin Li ◽  
Xilong Xiao ◽  
...  
Keyword(s):  
Dna Damage ◽  
S Phase ◽  
Human Hepatoma ◽  
Phase Arrest ◽  
S Phase Arrest ◽  
G2 Cells

scholarly journals Schizosaccharomyces pombe Checkpoint Response to DNA Interstrand Cross-Links

2003 ◽  
Vol 23 (13) ◽  
pp. 4728-4737 ◽  
Author(s):  
Sarah Lambert ◽  
Sarah J. Mason ◽  
Louise J. Barber ◽  
John A. Hartley ◽  
Jackie A. Pearce ◽  
...  
Keyword(s):  
Dna Damage ◽  
Schizosaccharomyces Pombe ◽  
Mammalian Cells ◽  
Excision Repair ◽  
S Phase ◽  
Repair Gene ◽  
Phase Arrest ◽  
S Phase Arrest ◽  
Interstrand Cross Links ◽  
Cross Links

ABSTRACT Drugs that produce covalent interstrand cross-links (ICLs) in DNA remain central to the treatment of cancer, but the cell cycle checkpoints activated by ICLs have received little attention. We have used the fission yeast, Schizosaccharomyces pombe, to elucidate the checkpoint responses to the ICL-inducing anticancer drugs nitrogen mustard and mitomycin C. First we confirmed that the repair pathways acting on ICLs in this yeast are similar to those in the main organisms studied to date (Escherichia coli, budding yeast, and mammalian cells), principally nucleotide excision repair and homologous recombination. We also identified and disrupted the S. pombe homologue of the Saccharomyces cerevisiae SNM1/PSO2 ICL repair gene and found that this activity is required for normal resistance to cross-linking agents, but not other forms of DNA damage. Survival and biochemical analysis indicated a key role for the “checkpoint Rad” family acting through the chk1-dependent DNA damage checkpoint in the ICL response. Rhp9-dependent phosphorylation of Chk1 correlates with G2 arrest following ICL induction. In cells able to bypass the G2 block, a second-cycle (S-phase) arrest was observed. Only a transient activation of the Cds1 DNA replication checkpoint factor occurs following ICL formation in wild-type cells, but this is increased and persists in G2 arrest-deficient mutants. This likely reflects the fraction of cells escaping the G2 damage checkpoint and arresting in the subsequent S phase due to ICL replication blocks. Disruption of cds1 confers increased resistance to ICLs, suggesting that this second-cycle S-phase arrest might be a lethal event.

scholarly journals Defective S Phase Chromatin Assembly Causes DNA Damage, Activation of the S Phase Checkpoint, and S Phase Arrest

2003 ◽  
Vol 11 (2) ◽  
pp. 341-351 ◽  
Author(s):  
Xiaofen Ye ◽  
Alexa A Franco ◽  
Hidelita Santos ◽  
David M Nelson ◽  
Paul D Kaufman ◽  
...  
Keyword(s):  
Dna Damage ◽  
S Phase ◽  
Chromatin Assembly ◽  
Phase Arrest ◽  
S Phase Arrest ◽  
S Phase Checkpoint

Inhibition of autophagy enhances DNA damage-induced apoptosis by disrupting CHK1-dependent S phase arrest

2014 ◽  
Vol 278 (3) ◽  
pp. 249-258 ◽  
Author(s):  
Jong-Shian Liou ◽  
Yi-Chen Wu ◽  
Wen-Yen Yen ◽  
Yu-Shuan Tang ◽  
Rajesh B. Kakadiya ◽  
...  
Keyword(s):  
Dna Damage ◽  
S Phase ◽  
Phase Arrest ◽  
S Phase Arrest ◽  
Induced Apoptosis

Zoledronic acid induces S-phase arrest via a DNA damage response in normal human oral keratinocytes

2012 ◽  
Vol 57 (7) ◽  
pp. 906-917 ◽  
Author(s):  
Hisashi Ohnuki ◽  
Kenji Izumi ◽  
Michiko Terada ◽  
Taro Saito ◽  
Hiroko Kato ◽  
...  
Keyword(s):  
Dna Damage ◽  
Zoledronic Acid ◽  
Dna Damage Response ◽  
S Phase ◽  
Oral Keratinocytes ◽  
Phase Arrest ◽  
Damage Response ◽  
S Phase Arrest ◽  
Normal Human

scholarly journals Cell Cycle Modulation by Marek’s Disease Virus: The Tegument Protein VP22 Triggers S-Phase Arrest and DNA Damage in Proliferating Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e100004 ◽  
Author(s):  
Laëtitia Trapp-Fragnet ◽  
Djihad Bencherit ◽  
Danièle Chabanne-Vautherot ◽  
Yves Le Vern ◽  
Sylvie Remy ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Damage ◽  
Disease Virus ◽  
S Phase ◽  
Tegument Protein ◽  
Proliferating Cells ◽  
Phase Arrest ◽  
Cell Cycle Modulation ◽  
S Phase Arrest ◽  
Protein Vp22

scholarly journals DNA damage-induced S phase arrest in human breast cancer depends on Chk1, but G2arrest can occur independently of Chk1, Chk2 or MAPKAPK2

Cell Cycle ◽  
2008 ◽  
Vol 7 (11) ◽  
pp. 1668-1677 ◽  
Author(s):  
Wen-Hui Zhang ◽  
Alissa Poh ◽  
Andrew A. Fanous ◽  
Alan Eastman
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Human Breast Cancer ◽  
S Phase ◽  
Human Breast ◽  
Phase Arrest ◽  
S Phase Arrest
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