scholarly journals DNA damage-induced S phase arrest in human breast cancer depends on Chk1, but G2arrest can occur independently of Chk1, Chk2 or MAPKAPK2

Cell Cycle ◽  
2008 ◽  
Vol 7 (11) ◽  
pp. 1668-1677 ◽  
Author(s):  
Wen-Hui Zhang ◽  
Alissa Poh ◽  
Andrew A. Fanous ◽  
Alan Eastman
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Human Breast Cancer ◽  
S Phase ◽  
Human Breast ◽  
Phase Arrest ◽  
S Phase Arrest

Molecular Mechanisms of Thymoquinone as Anticancer agent

2020 ◽  
Vol 23 ◽  
Author(s):  
Fatma Ismail Alhmied ◽  
Ali Hassan Alammar ◽  
Bayan Mohammed Alsultan ◽  
Marooj Alshehri ◽  
Faheem Hyder Pottoo
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Human Breast Cancer ◽  
Phase Cell ◽  
Cycle Phase ◽  
Human Breast ◽  
Cycle Arrest ◽  
Phase Arrest ◽  
Anti Cancer

Abstract:: Thymoquinone (TQ), the bioactive constituent of Nigella Sativa seeds is a well-known natural compound for the management of several types of cancers. The anti-cancer properties of thymoquinone are thought to be operated via intervening with various oncogenic pathways including cell cycle arrest, prevention of inflammation and oxidative stress, induction of invasion, metastasis, inhibition of angiogenesis, and apoptosis. As well as up-regulation and down-regulation of specific tumor suppressor genes and tumor promoting genes, respectively. Proliferation of various tumor cells is inhibited by TQ via induction of cell cycle arrest, disruption of the microtubule organization, and down regulating cell survival protein expression. TQ induces G1 phase cell cycle arrest in human breast cancer, colon cancer and osteosarcoma cells through inhibiting the activation of cyclin E or cyclin D and up-regulating p27and p21 a cyclin dependent kinase (Cdk) inhibitor. TQ concentration is a significant factor in targeting a particular cell cycle phase. While high concentration of TQ induced G2 phase arrest in human breast cancer (MCF-7) cells, low concentration causes S phase arrest. This review article provides mechanistic insights into the anti-cancer properties of thymoquinone.

Loss of Retinoblastoma Gene (RB1) Is Associated with Deletions at the 17p13.3 Chromosome and S-Phase Index in Human Breast Cancer

1996 ◽  
Vol 784 (1 Challenges an) ◽  
pp. 462-466
Author(s):  
TIZIANA VENESIO ◽  
AMELIA BERNARDI ◽  
ANTONELLA SCORDAMAGLIA ◽  
PAOLO FERRERO ◽  
MONICA SALVEGO ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
S Phase ◽  
Retinoblastoma Gene ◽  
Human Breast ◽  
Phase Index

scholarly journals GADD45a Regulates Olaquindox-Induced DNA Damage and S-Phase Arrest in Human Hepatoma G2 Cells via JNK/p38 Pathways

Molecules ◽  
2017 ◽  
Vol 22 (1) ◽  
pp. 124 ◽  
Author(s):  
Daowen Li ◽  
Chongshan Dai ◽  
Xiayun Yang ◽  
Bin Li ◽  
Xilong Xiao ◽  
...  
Keyword(s):  
Dna Damage ◽  
S Phase ◽  
Human Hepatoma ◽  
Phase Arrest ◽  
S Phase Arrest ◽  
G2 Cells
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