scholarly journals Verdinexor, a Selective Inhibitor of Nuclear Exportin 1, Inhibits the Proliferation and Migration of Esophageal Cancer via XPO1/c-Myc/FOSL1 Axis

2022 ◽  
Vol 18 (1) ◽  
pp. 276-291
Author(s):  
Ling Ou ◽  
Xinyou Wang ◽  
Shumin Cheng ◽  
Min Zhang ◽  
Ruiqin Cui ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Selective Inhibitor ◽  
And Migration ◽  
Proliferation And Migration

FAM196B promotes proliferation and migration via regulating epithelial-mesenchymal transition in esophageal cancer

2021 ◽  
pp. 1-8
Author(s):  
Haifeng Xia ◽  
Fang Hu ◽  
Liangbin Pan ◽  
Chengcheng Xu ◽  
Haitao Huang ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Western Blot ◽  
Cox Regression ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Cox Regression Analysis ◽  
Ec Cells ◽  
And Migration ◽  
Proliferation And Migration

BACKGROUND: EC (esophageal cancer) is a common cancer among people in the world. The molecular mechanism of FAM196B (family with sequence similarity 196 member B) in EC is still unclear. This article aimed to clarify the role of FAM196B in EC. METHODS: The expression of FAM196B in EC tissues was detected using qRT-PCR. The prognosis of FAM196B in EC patients was determined by log-rank kaplan-Meier survival analysis and Cox regression analysis. Furthermore, shRNA was used to knockdown the expression of FAM196B in EC cell lines. MTT, wound healing assays and western blot were used to determine the role of FAM196B in EC cells. RESULTS: In our research, we found that the expression of FAM196B was up-regulated in EC tissues. The increased expression of FAM196B was significantly correlated with differentiation, lymph node metastasis, stage, and poor survival. The proliferation and migration of EC cells were inhibited after FAM196B-shRNA transfection in vitro and vivo. The western blot result showed that FAM196B could regulate EMT. CONCLUSION: These results suggested that FAM196B severs as an oncogene and promotes cell proliferation and migration in EC. In addition, FAM196B may be a potential therapeutic target for EC patients.

Steroidal dimer by001 inhibits proliferation and migration of esophageal cancer cells via multiple mechanisms

2018 ◽  
Vol 83 (1) ◽  
pp. 179-189
Author(s):  
Sai-Qi Wang ◽  
Kai-Rui Zhou ◽  
Xiao-Li Shi ◽  
Hui-Fang Lv ◽  
Liang-Yu Bie ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Cells ◽  
And Migration ◽  
Esophageal Cancer Cells ◽  
Proliferation And Migration

scholarly journals Downregulation of esophageal cancer-related gene 4 promotes proliferation and migration of hepatocellular carcinoma

2017 ◽  
Vol 14 (3) ◽  
pp. 3689-3696 ◽  
Author(s):  
Shujian Ge ◽  
Yali Xu ◽  
Hongliang Wang ◽  
Yaxin Sun ◽  
Xiangguo Tian ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Esophageal Cancer ◽  
Related Gene ◽  
Cancer Related Gene ◽  
And Migration ◽  
Gene 4 ◽  
Proliferation And Migration

miR-34a inhibits the in vitro cell proliferation and migration in human esophageal cancer

2016 ◽  
Vol 212 (5) ◽  
pp. 444-449 ◽  
Author(s):  
Hui Shi ◽  
Shengluan Zhou ◽  
Junhua Liu ◽  
Jun Zhu ◽  
Jianhua Xue ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Esophageal Cancer ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Human Esophageal Cancer ◽  
Proliferation And Migration

scholarly journals Mechanism and Role of the Neuropeptide LGI1 Receptor ADAM23 in Regulating Biomarkers of Ferroptosis and Progression of Esophageal Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Chen Chen ◽  
Jun Zhao ◽  
Jing-ni Liu ◽  
Chenyu Sun
Keyword(s):  
Esophageal Cancer ◽  
Cell Lines ◽  
Noncoding Rna ◽  
The Cancer Genome Atlas ◽  
Cell Counting ◽  
Luciferase Reporter ◽  
Cerna Network ◽  
And Migration ◽  
Proliferation And Migration

Background. According to recent studies, ferroptosis is closely related to the efficacy and prognosis of tumour treatment. However, the role of ferroptosis in esophageal squamous cell carcinoma (ESCC) has not been explored comprehensively. Materials and Methods. The esophageal cancer (EC) transcriptome data was downloaded from The Cancer Genome Atlas (TCGA), then analyzed, to obtain the differentially expressed messenger RNA (mRNA), microRNA (miRNA), and long noncoding RNA (lncRNA) between groups with the low and high Ferroptosis Potential Index (FPI) and construct a ferroptosis-associated ceRNA network. In addition, the expression of ARHGEF26-AS1 and miR-372-3p in ESCC cell lines was assessed, and the appropriate cell lines were selected. The interaction between ARHGEF26-AS1, miR-372-3p, and ADAM23 was also determined through a dual-luciferase reporter assay. Moreover, the Western blot, Cell Counting Kit-8 (CCK-8), wound healing, cell viability, and cell death assays were conducted to establish the biological functions of the ARHGEF26-AS1/miR-372-3p/ADAM23 pathway in ESCCs. Results. An FPI scoring model reflecting the activity of the ferroptosis pathway was constructed, and a ferroptosis-associated ceRNA network was established. The findings revealed that low expression of ADAM23 and ARHGEF26-AS1 as well as high expression of miR-372-3p was associated with poor prognosis and a lower FPI score in EC patients. Functionally, overexpression of ADAM23 and ARHGEF26-AS1 and the miR-372-3p inhibitor not only promoted ferroptosis in ESCC cells in vitro but also inhibited the proliferation and migration of cells. Mechanistically, ARHGEF26-AS1 upregulated the expression of ADAM23 by competitively binding to miR-372-3p. Conclusions. The study showed that the lncRNA, ARHGEF26-AS1 acts as a miR-372-3p sponge that regulates the neuropeptide LGI1 receptor ADAM23 expression. This in turn not only inhibits the proliferation and migration of ESCC cells but also upregulates the ferroptosis pathway. A neuropeptide-related ferroptosis regulatory pathway was identified in this study.

MiR-196a promotes the proliferation and migration of esophageal cancer via the UHRF2/TET2 axis

2021 ◽  
Author(s):  
Chang-mei Hu ◽  
Jie Peng ◽  
Liang Lv ◽  
Xue-hong Wang ◽  
Ji-rong Huo ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
And Migration ◽  
Proliferation And Migration
Sign in / Sign up

Export Citation Format

Share Document