scholarly journals Enhanced Intracellular Reactive Oxygen Species by Photodynamic Therapy Effectively Promotes Chemoresistant Cell Death

2022 ◽  
Vol 18 (1) ◽  
pp. 374-385
Author(s):  
Xiaolin Xu ◽  
Chenglong Wang ◽  
Peipei Zhang ◽  
Xuzhu Gao ◽  
Wencai Guan ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Reactive Oxygen ◽  
Intracellular Reactive Oxygen Species ◽  
Oxygen Species ◽  
Chemoresistant Cell

scholarly journals Combination of photodynamic therapy (PDT) and anti-tumor immunity in cancer therapy

2018 ◽  
Vol 48 (2) ◽  
pp. 143-151 ◽  
Author(s):  
Hee Sook Hwang ◽  
Heejun Shin ◽  
Jieun Han ◽  
Kun Na
Keyword(s):  
Reactive Oxygen Species ◽  
Immune Response ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Adaptive Immune Response ◽  
Reactive Oxygen ◽  
Ros Generation ◽  
Oxygen Species ◽  
Tumor Cell Death ◽  
Target Sites

Abstract Photodynamic therapy (PDT) is performed using a photosensitizer and light of specific wavelength in the presence of oxygen to generate singlet oxygen and reactive oxygen species(ROS) in the cancer cells. The accumulated photosensitizers in target sites induce ROS generation upon light activation, then the generated cytotoxic reactive oxygen species lead to tumor cell death via apoptosis or necrosis, and damages the target sites which results tumor destruction. As a consequence, the PDT-mediated cell death is associated with anti-tumor immune response. In this paper, the effects of PDT and immune response on tumors are reviewed. Activation of an immune response regarding the innate and adaptive immune response, interaction with immune cells and tumor cells that associated with antitumor efficacy of PDT are also discussed.

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