scholarly journals BIX-01294 induces autophagy-associated cell death via EHMT2/G9a dysfunction and intracellular reactive oxygen species production

Autophagy ◽  
2013 ◽  
Vol 9 (12) ◽  
pp. 2126-2139 ◽  
Author(s):  
Yunha Kim ◽  
Yong-Sook Kim ◽  
Dong Eun Kim ◽  
Jee Suk Lee ◽  
Ji Hoon Song ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Reactive Oxygen Species Production ◽  
Reactive Oxygen ◽  
Intracellular Reactive Oxygen Species ◽  
Oxygen Species ◽  
Species Production

scholarly journals Intracellular Reactive Oxygen Species Production by Polymorphonuclear Leukocytes in Bovine Leukemia Virus-Infected Dairy Cows

2012 ◽  
Vol 74 (2) ◽  
pp. 221-225 ◽  
Author(s):  
Fernando Nogueira de SOUZA ◽  
Maiara Garcia BLAGITZ ◽  
Andréia Oliveira LATORRE ◽  
Eduardo Milton RAMOS SANCHEZ ◽  
Camila Freitas BATISTA ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Dairy Cows ◽  
Bovine Leukemia Virus ◽  
Polymorphonuclear Leukocytes ◽  
Reactive Oxygen Species Production ◽  
Leukemia Virus ◽  
Reactive Oxygen ◽  
Intracellular Reactive Oxygen Species ◽  
Oxygen Species ◽  
Species Production

scholarly journals Pomegranate-Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3-Mediated SOD2 Activation

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Chong Zhao ◽  
Takenori Sakaguchi ◽  
Kosuke Fujita ◽  
Hideyuki Ito ◽  
Norihisa Nishida ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Antioxidant Activity ◽  
Reactive Oxygen Species Production ◽  
Reactive Oxygen ◽  
Intracellular Reactive Oxygen Species ◽  
Oxygen Species ◽  
Food Ingredients ◽  
Underlying Mechanisms ◽  
Species Production ◽  
Superoxide Dismutase 2

Pomegranate-derived polyphenols are expected to prevent life-style related diseases. In this study, we evaluated the ability of 8 pomegranate-derived polyphenols, along with other polyphenols, to augment SIRT3, a mammalian SIR2 homolog localized in mitochondria. We established a system for screening foods/food ingredients that augment the SIRT3 promoter in Caco-2 cells and identified 3 SIRT3-augmenting pomegranate-derived polyphenols (eucalbanin B, pomegraniin A, and eucarpanin T1). Among them, pomegraniin A activated superoxide dismutase 2 (SOD2) through SIRT3-mediated deacetylation, thereby reducing intracellular reactive oxygen species. The other SIRT3-augmenting polyphenols tested also activated SOD2, suggesting antioxidant activity. Our findings clarify the underlying mechanisms involved in the antioxidant activity of pomegraniin A.

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