scholarly journals Thymoquinone Suppresses the Proliferation, Migration and Invasiveness through Regulating ROS, Autophagic Flux and miR-877-5p in Human Bladder Carcinoma Cells

2021 ◽  
Vol 17 (13) ◽  
pp. 3456-3475
Author(s):  
Xuejian Zhou ◽  
Feifan Wang ◽  
Hongshen Wu ◽  
Xianwu Chen ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Bladder Carcinoma ◽  
Carcinoma Cells ◽  
Autophagic Flux ◽  
Human Bladder ◽  
Bladder Carcinoma Cells

scholarly journals Molecular targets for the protodynamic action of cis-urocanic acid in human bladder carcinoma cells

BMC Cancer ◽  
2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Emilia Peuhu ◽  
Aura Kaunisto ◽  
Jarmo K Laihia ◽  
Lasse Leino ◽  
John E Eriksson
Keyword(s):  
Bladder Carcinoma ◽  
Molecular Targets ◽  
Urocanic Acid ◽  
Carcinoma Cells ◽  
Human Bladder ◽  
Bladder Carcinoma Cells

scholarly journals Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells

2002 ◽  
Vol 1565 (1) ◽  
pp. 112-122 ◽  
Author(s):  
Do Kyung Kim ◽  
Yoshikatsu Kanai ◽  
Hye Won Choi ◽  
Sahatchai Tangtrongsup ◽  
Arthit Chairoungdua ◽  
...  
Keyword(s):  
Amino Acid ◽  
Bladder Carcinoma ◽  
Amino Acid Transporter ◽  
Carcinoma Cells ◽  
Human Bladder ◽  
System L ◽  
Acid Transporter ◽  
Bladder Carcinoma Cells

scholarly journals Transgelin, a p53 and PTEN-Upregulated Gene, Inhibits the Cell Proliferation and Invasion of Human Bladder Carcinoma Cells in Vitro and in Vivo

2019 ◽  
Vol 20 (19) ◽  
pp. 4946 ◽  
Author(s):  
Tsui ◽  
Lin ◽  
Chang ◽  
Hou ◽  
Chen ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Epithelial Cells ◽  
Bladder Carcinoma ◽  
Carcinoma Cells ◽  
Human Bladder ◽  
Ectopic Overexpression ◽  
Proliferation And Invasion ◽  
Bladder Carcinoma Cells

Transgelin (TAGLN/SM22-α) is a regulator of the actin cytoskeleton, affecting the survival, migration, and apoptosis of various cancer cells divergently; however, the roles of TAGLN in bladder carcinoma cells remain inconclusive. We compared expressions of TAGLN in human bladder carcinoma cells to the normal human bladder tissues to determine the potential biological functions and regulatory mechanisms of TAGLN in bladder carcinoma cells. Results of RT-qPCR and immunoblot assays indicated that TAGLN expressions were higher in bladder smooth muscle cells, fibroblast cells, and normal epithelial cells than in carcinoma cells (RT-4, HT1376, TSGH-8301, and T24) in vitro. Besides, the results of RT-qPCR revealed that TAGLN expressions were higher in normal tissues than the paired tumor tissues. In vitro, TAGLN knockdown enhanced cell proliferation and invasion, while overexpression of TAGLN had the inverse effects in bladder carcinoma cells. Meanwhile, ectopic overexpression of TAGLN attenuated tumorigenesis in vivo. Immunofluorescence and immunoblot assays showed that TAGLN was predominantly in the cytosol and colocalized with F-actin. Ectopic overexpression of either p53 or PTEN induced TAGLN expression, while p53 knockdown downregulated TAGLN expression in bladder carcinoma cells. Our results indicate that TAGLN is a p53 and PTEN-upregulated gene, expressing higher levels in normal bladder epithelial cells than carcinoma cells. Further, TAGLN inhibited cell proliferation and invasion in vitro and blocked tumorigenesis in vivo. Collectively, it can be concluded that TAGLN is an antitumor gene in the human bladder.

Induction of acidic sphingomyelinase by electrophiles in human bladder carcinoma cells

2007 ◽  
Vol 149 ◽  
pp. S83
Author(s):  
Takeshi Kumagai ◽  
Yuichi Yajima ◽  
Yosuke Kozakai ◽  
Yasuhito Nakagawa
Keyword(s):  
Bladder Carcinoma ◽  
Carcinoma Cells ◽  
Human Bladder ◽  
Bladder Carcinoma Cells

scholarly journals BTG2 is a tumor suppressor gene upregulated by p53 and PTEN in human bladder carcinoma cells

2017 ◽  
Vol 7 (1) ◽  
pp. 184-195 ◽  
Author(s):  
Ke-Hung Tsui ◽  
Kun-Chun Chiang ◽  
Yu-Hsiang Lin ◽  
Kang-Shuo Chang ◽  
Tsui-Hsia Feng ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Bladder Carcinoma ◽  
Suppressor Gene ◽  
Carcinoma Cells ◽  
Human Bladder ◽  
Bladder Carcinoma Cells

Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells

2005 ◽  
Vol 70 (1) ◽  
pp. 121-133 ◽  
Author(s):  
Tsipi Ben-Kasus ◽  
Zvi Ben-Zvi ◽  
Victor E. Marquez ◽  
James A. Kelley ◽  
Riad Agbaria
Keyword(s):  
Dna Methylation ◽  
Bladder Carcinoma ◽  
Metabolic Activation ◽  
Carcinoma Cells ◽  
Human Bladder ◽  
Methylation Inhibitor ◽  
Dna Methylation Inhibitor ◽  
Bladder Carcinoma Cells
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