scholarly journals Inhibition of Sirtuin 3 prevents titanium particle-induced bone resorption and osteoclastsogenesis via suppressing ERK and JNK signaling

2021 ◽  
Vol 17 (5) ◽  
pp. 1382-1394
Author(s):  
Ning Li ◽  
Xiaoping Li ◽  
Kai Zheng ◽  
Jiaxiang Bai ◽  
Weicheng Zhang ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Sirtuin 3 ◽  
Titanium Particle ◽  
Jnk Signaling

scholarly journals Dihydroartemisinin prevents breast cancer-induced osteolysis via inhibiting both breast caner cells and osteoclasts

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Ming-Xuan Feng ◽  
Jian-Xin Hong ◽  
Qiang Wang ◽  
Yong-Yong Fan ◽  
Chi-Ting Yuan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Resorption ◽  
Molecular Mechanisms ◽  
Osteoclast Differentiation ◽  
Metastatic Breast ◽  
Osteoclast Formation ◽  
Migration And Invasion ◽  
Titanium Particle

Abstract Bone is the most common site of distant relapse in breast cancer, leading to severe complications which dramatically affect the patients’ quality of life. It is believed that the crosstalk between metastatic breast cancer cells and osteoclasts is critical for breast cancer-induced osteolysis. In this study, the effects of dihydroartemisinin (DHA) on osteoclast formation, bone resorption, osteoblast differentiation and mineralization were initially assessed in vitro, followed by further investigation in a titanium-particle-induced osteolysis model in vivo. Based on the proved inhibitory effect of DHA on osteolysis, DHA was further applied to MDA-MB-231 breast cancer-induced mouse osteolysis model, with the underlying molecular mechanisms further investigated. Here, we verified for the first time that DHA suppressed osteoclast differentiation, F-actin ring formation and bone resorption through suppressing AKT/SRC pathways, leading to the preventive effect of DHA on titanium-particle-induced osteolysis without affecting osteoblast function. More importantly, we demonstrated that DHA inhibited breast tumor-induced osteolysis through inhibiting the proliferation, migration and invasion of MDA-MB-231 cells via modulating AKT signaling pathway. In conclusion, DHA effectively inhibited osteoclastogenesis and prevented breast cancer-induced osteolysis.

Protein phosphatase 2A as a new target for downregulating osteoclastogenesis and alleviating titanium particle-induced bone resorption

2018 ◽  
Vol 73 ◽  
pp. 488-499 ◽  
Author(s):  
Liangliang Wang ◽  
Xiaobin Guo ◽  
Wei Zhou ◽  
Yayun Ding ◽  
Jiawei Shi ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Protein Phosphatase ◽  
Protein Phosphatase 2A ◽  
Titanium Particle ◽  
Phosphatase 2A

scholarly journals Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway

Oncotarget ◽  
2016 ◽  
Vol 7 (31) ◽  
pp. 50117-50130 ◽  
Author(s):  
Na-Na Tao ◽  
Hong-Zhong Zhou ◽  
Hua Tang ◽  
Xue-Fei Cai ◽  
Wen-Lu Zhang ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Drug Sensitivity ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Glutathione S Transferase ◽  
Sirtuin 3 ◽  
Human Hepatoma Cells ◽  
Jnk Signaling ◽  
Jnk Signaling Pathway

Inhibition of NFAM1 suppresses phospho‐SAPK/JNK signaling during osteoclast differentiation and bone resorption

2021 ◽  
Author(s):  
Purushoth Ethiraj ◽  
Ishraq A. Haque ◽  
Anna K. Alford ◽  
Wenyu Gou ◽  
Toolika Singh ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Osteoclast Differentiation ◽  
Jnk Signaling

Inhibitory effects of melatonin on titanium particle-induced inflammatory bone resorption and osteoclastogenesis via suppression of NF-κB signaling

2017 ◽  
Vol 62 ◽  
pp. 362-371 ◽  
Author(s):  
Zichuan Ping ◽  
Zhirong Wang ◽  
Jiawei Shi ◽  
Liangliang Wang ◽  
Xiaobin Guo ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Inhibitory Effects ◽  
Titanium Particle
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