Inhibitory effects of biochanin A on titanium particle‐induced osteoclast activation and inflammatory bone resorption via NF‐κB and MAPK pathways

2020 ◽  
Vol 236 (2) ◽  
pp. 1432-1444
Author(s):  
Shijie Liao ◽  
Wenyu Feng ◽  
Yun Liu ◽  
Ziyi Wang ◽  
Xiaofei Ding ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Biochanin A ◽  
Inhibitory Effects ◽  
Titanium Particle ◽  
Mapk Pathways ◽  
Osteoclast Activation

Inhibitory effects of melatonin on titanium particle-induced inflammatory bone resorption and osteoclastogenesis via suppression of NF-κB signaling

2017 ◽  
Vol 62 ◽  
pp. 362-371 ◽  
Author(s):  
Zichuan Ping ◽  
Zhirong Wang ◽  
Jiawei Shi ◽  
Liangliang Wang ◽  
Xiaobin Guo ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Inhibitory Effects ◽  
Titanium Particle

Interaction between amrinone and parathyroid hormone on bone in culture

1982 ◽  
Vol 243 (6) ◽  
pp. E499-E504
Author(s):  
N. S. Krieger ◽  
P. H. Stern
Keyword(s):  
Parathyroid Hormone ◽  
Bone Resorption ◽  
Direct Interaction ◽  
Inhibitory Effects ◽  
Dihydroxyvitamin D3 ◽  
Basal Bone ◽  
Cardiotonic Agent ◽  
Neonatal Mouse Calvaria ◽  
Dose Dependent ◽  
Stimulation Of

The cardiotonic agent amrinone has been postulated to directly affect Na-Ca exchange. Because stimulated bone resorption has been proposed to require Na-Ca exchange, we examined the effects of amrinone on bone. Amrinone inhibited release of Ca from neonatal mouse calvaria in organ culture stimulated by parathyroid hormone (PTH), 1,25-dihydroxyvitamin d3, or prostaglandin E2. Inhibition was dose dependent and maximal at 2 X 10(-4) M. The effect of amrinone differed from the inhibitory effects of calcitonin, ouabain, or nigericin in that 1) 6-h exposure to amrinone alone prevented the effect of subsequently added PTH; 2) amrinone was only partially effective if added after resorption was initiated by 24-h treatment with PTH; 3) coincubation with amrinone and PTH during the first 48 h of culture allowed for a response to PTH after amrinone was removed; no such protection by a stimulator occurred with ouabain or nigericin. Also submaximal concentrations of amrinone plus calcitonin, ouabain, or nigericin gave greater than additive inhibition of Ca release. Amrinone had no effect on basal bone cAMP or on the acute stimulation of cAMP by PTH. The results suggest that amrinone could have a more direct interaction with the pathway involved in stimulated bone resorption than the other inhibitors.

Mechanisms of the growth inhibitory effects of the isoflavonoid biochanin A on LNCaP cells and xenografts

The Prostate ◽  
2002 ◽  
Vol 52 (3) ◽  
pp. 201-212 ◽  
Author(s):  
Lori Rice ◽  
Von G. Samedi ◽  
Theresa A. Medrano ◽  
Carol A. Sweeney ◽  
Henry V. Baker ◽  
...  
Keyword(s):  
Biochanin A ◽  
Lncap Cells ◽  
Inhibitory Effects ◽  
Growth Inhibitory

Inhibitory effects of human gingival extracts on bone resorption in vitro

1986 ◽  
Vol 21 (5) ◽  
pp. 455-461 ◽  
Author(s):  
Z. Schwartz ◽  
K. Nuki ◽  
L. G. Raisz ◽  
W. A. Soskolne
Keyword(s):  
Bone Resorption ◽  
Inhibitory Effects

Inhibitory Effects of 1',2'-Dihydrorotenone on Osteoclast Differentiation and Bone Resorption In Vitro and In Vivo

2011 ◽  
Vol 24 (3) ◽  
pp. 165
Author(s):  
Kwang Jin Kim ◽  
Han Bok Kwak ◽  
Eun Yong Choi ◽  
Jaemin Oh ◽  
Min Kyu Choi ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Osteoclast Differentiation ◽  
Inhibitory Effects

scholarly journals Dihydroartemisinin prevents breast cancer-induced osteolysis via inhibiting both breast caner cells and osteoclasts

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Ming-Xuan Feng ◽  
Jian-Xin Hong ◽  
Qiang Wang ◽  
Yong-Yong Fan ◽  
Chi-Ting Yuan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Resorption ◽  
Molecular Mechanisms ◽  
Osteoclast Differentiation ◽  
Metastatic Breast ◽  
Osteoclast Formation ◽  
Migration And Invasion ◽  
Titanium Particle

Abstract Bone is the most common site of distant relapse in breast cancer, leading to severe complications which dramatically affect the patients’ quality of life. It is believed that the crosstalk between metastatic breast cancer cells and osteoclasts is critical for breast cancer-induced osteolysis. In this study, the effects of dihydroartemisinin (DHA) on osteoclast formation, bone resorption, osteoblast differentiation and mineralization were initially assessed in vitro, followed by further investigation in a titanium-particle-induced osteolysis model in vivo. Based on the proved inhibitory effect of DHA on osteolysis, DHA was further applied to MDA-MB-231 breast cancer-induced mouse osteolysis model, with the underlying molecular mechanisms further investigated. Here, we verified for the first time that DHA suppressed osteoclast differentiation, F-actin ring formation and bone resorption through suppressing AKT/SRC pathways, leading to the preventive effect of DHA on titanium-particle-induced osteolysis without affecting osteoblast function. More importantly, we demonstrated that DHA inhibited breast tumor-induced osteolysis through inhibiting the proliferation, migration and invasion of MDA-MB-231 cells via modulating AKT signaling pathway. In conclusion, DHA effectively inhibited osteoclastogenesis and prevented breast cancer-induced osteolysis.

scholarly journals Mechanism in Inhibitory Effects of Vitamin K2 on Osteoclastic Bone Resorption: In Vivo Study in Osteopetrotic (op/op) Mice.

1999 ◽  
Vol 45 (4) ◽  
pp. 501-507 ◽  
Author(s):  
Toshitsugu KAWATA ◽  
Joseph H. ZERNIK ◽  
Tadashl FUJITA ◽  
Chiyoko TOKIMASA ◽  
Kazuo TANNE
Keyword(s):  
Bone Resorption ◽  
Vitamin K2 ◽  
Osteoclastic Bone Resorption ◽  
In Vivo Study ◽  
Inhibitory Effects
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