scholarly journals Growth suppression activity of bradykinin antagonists in glioma cells

2014 ◽  
Vol 30 (1) ◽  
pp. 77-79 ◽  
Author(s):  
S. S. Avdieiev ◽  
L. Gera ◽  
R. Hodges ◽  
Y. S. Vassetzky ◽  
V. M. Kavsan
Keyword(s):  
Glioma Cells ◽  
Growth Suppression ◽  
Bradykinin Antagonists

scholarly journals Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

1997 ◽  
Vol 94 (23) ◽  
pp. 12479-12484 ◽  
Author(s):  
F. B. Furnari ◽  
H. Lin ◽  
H.- J. S. Huang ◽  
W. K. Cavenee
Keyword(s):  
Catalytic Domain ◽  
Glioma Cells ◽  
Growth Suppression

Growth suppression and astrocytic differentiation of glioma cells by interleukin-1

1994 ◽  
Vol 81 (3) ◽  
pp. 402-410 ◽  
Author(s):  
Satoshi Tanaka ◽  
Tadashi Nagashima ◽  
Shinya Manaka ◽  
Tomokatsu Hori ◽  
Shigeru Yasumoto
Keyword(s):  
Cell Growth ◽  
Cell Lines ◽  
Glioma Cell ◽  
Interleukin 1 ◽  
Glioma Cells ◽  
Growth Suppression ◽  
Transient Growth ◽  
Glioma Cell Lines ◽  
Astrocytic Differentiation

✓ The effect of recombinant human interleukin-1 (rHuIL-1) derivatives on human glioma cell lines was examined in vitro. Five glioma cell lines, U-251 MG, U-373 MG, U-87 MG, A-172, and T98G, were incubated in medium containing 1% fetal calf serum and various concentrations of different types of rHuIL-1: OCT-43 (rHuIL-1β), OCT-7000 (rHuIL-1α), and OCT-8000 (rHuIL-1α). The high-affinity IL-1 receptors were expressed in the U-251 MG and U-373 MG cell lines, and rHuIL-1 was found to suppress cell growth and to induce morphological differentiation of these cell lines. Growth inhibition occurred in a dose-dependent manner in concentrations or rHuIL-1 ranging between 1 and 100 ng/ml. Interestingly, rHuIL-1 induced a transient growth of glioma cells shortly after administration, then suppressed cell growth with accompanying elongation of cytoplasmic processes. This unique process of transient growth stimulation followed by growth suppression was parallel to the efficacy of bromodeoxyuridine uptake in the rHuIL-1-treated cells. Concomitantly, accumulation of glial fibrillary acidic protein and cyclic adenosine monophosphate contents was observed in four glioma cell lines. Continuous rHuIL-1 treatment for longer than 30 days elicited irreversible astrocytic terminal differentiation. These results indicate that IL-1 is an effector on the growth regulation of glioma cells, resulting in astrocytic differentiation in vitro.

scholarly journals Effect of DcR3-specific siRNA on cell growth suppression and apoptosis induction in glioma cells via affecting ERK and AKT

2016 ◽  
Vol Volume 9 ◽  
pp. 5195-5202 ◽  
Author(s):  
Zhuxin Wei ◽  
Yu Zhang ◽  
Suning Huang ◽  
Yuhua Leng ◽  
Xin Chen ◽  
...  
Keyword(s):  
Cell Growth ◽  
Glioma Cells ◽  
Growth Suppression ◽  
Apoptosis Induction ◽  
Cell Growth Suppression

scholarly journals Nimotuzumab enhances temozolomide‐induced growth suppression of glioma cells expressing mutant EGFR in vivo

2016 ◽  
Vol 5 (3) ◽  
pp. 486-499 ◽  
Author(s):  
Yusuke Nitta ◽  
Saki Shimizu ◽  
Yukiko Shishido‐Hara ◽  
Kaori Suzuki ◽  
Yoshiaki Shiokawa ◽  
...  
Keyword(s):  
Glioma Cells ◽  
Growth Suppression ◽  
Mutant Egfr

scholarly journals Effect of TNFRSF6B neutralization antibody on cell growth suppression and apoptosis induction in glioma cells

Neoplasma ◽  
2015 ◽  
Vol 62 (04) ◽  
pp. 574-581 ◽  
Author(s):  
Y. RUAN ◽  
S. HUANG ◽  
D. HE ◽  
R. GOPAUL ◽  
Z. LI ◽  
...  
Keyword(s):  
Cell Growth ◽  
Glioma Cells ◽  
Growth Suppression ◽  
Apoptosis Induction ◽  
Cell Growth Suppression

scholarly journals Infectious delivery of the 132 kb CDKN2A/CDKN2B genomic DNA region results in correctly spliced gene expression and growth suppression in glioma cells

Gene Therapy ◽  
2004 ◽  
Vol 11 (15) ◽  
pp. 1195-1204 ◽  
Author(s):  
R Inoue ◽  
K A Moghaddam ◽  
M Ranasinghe ◽  
Y Saeki ◽  
E A Chiocca ◽  
...  
Keyword(s):  
Gene Expression ◽  
Genomic Dna ◽  
Glioma Cells ◽  
Growth Suppression

scholarly journals Elevated intracellular cAMP concentration mediates growth suppression in glioma cells

2020 ◽  
Vol 174 ◽  
pp. 113823
Author(s):  
Dewi Safitri ◽  
Matthew Harris ◽  
Harriet Potter ◽  
Ho Yan Yeung ◽  
Ian Winfield ◽  
...  
Keyword(s):  
Glioma Cells ◽  
Growth Suppression ◽  
Intracellular Camp ◽  
Camp Concentration ◽  
Intracellular Camp Concentration
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