scholarly journals The second dissociation constant of p-phenolsulfonic acid and pH values of phenolsulfonate-chloride buffers from 0 degrees to 60 degrees C

1943 ◽  
Vol 31 (4) ◽  
pp. 205 ◽  
Author(s):  
R.G. Bates ◽  
G.L. Siegel ◽  
S.F. Acree
Keyword(s):  
Dissociation Constant ◽  
Ph Values ◽  
Second Dissociation Constant

scholarly journals pH-controlled hydrogen-bonding (Short Communication)

1974 ◽  
Vol 143 (3) ◽  
pp. 775-777 ◽  
Author(s):  
John L. Wood
Keyword(s):  
Hydrogen Bonding ◽  
Dissociation Constant ◽  
Small Proportion ◽  
Association Constant ◽  
Short Communication ◽  
Dibasic Acid ◽  
Ph Dependence ◽  
Ph Values ◽  
Conjugate Acid ◽  
Total Base

The pH-dependence of the degree of hydrogen-bonding between a base and its conjugate acid is considered. When only a small proportion of the total base is complexed, the amount complexed is proportional to (1+coshp)−1 where p=2.303 (pKa–pH), pKa being the dissociation constant of the conjugate acid. This represents sharp pH-dependence. As the proportion complexed increases, the curve broadens, eventually becoming flat-topped, with more than half the base complexed over the range of pH values pKa±logKC, approximately. (K is the complex association constant and C is the formal base concentration, including all forms.) There are similarities to the extent of mono-protonation of a dibasic acid.

Second dissociation constant of 3-(N-morpholino)-2-hydroxypropanesulfonic acid and pH of its buffer solutions

1993 ◽  
Vol 65 (8) ◽  
pp. 1084-1087 ◽  
Author(s):  
Y. C. Wu ◽  
P. A. Berezansky ◽  
Daming. Feng ◽  
W. F. Koch
Keyword(s):  
Dissociation Constant ◽  
Buffer Solutions ◽  
Second Dissociation Constant

Chromatographic Determination of Thermodynamic Acid Dissociation Constants of Tetracycline Antibiotics and Their Epimers

2019 ◽  
Vol 57 (8) ◽  
pp. 745-750
Author(s):  
İlkay Konçe ◽  
Ebru Çubuk Demiralay ◽  
Hülya Yılmaz Ortak
Keyword(s):  
Experimental Data ◽  
Dissociation Constant ◽  
Binary Mixtures ◽  
Dissociation Constants ◽  
Reversed Phase ◽  
Acid Dissociation ◽  
Acid Dissociation Constant ◽  
Chromatography Method ◽  
Ph Values

Abstract The presented study describes the development of reversed-phase liquid chromatography method using a core-shell particle column with a pentafluorophenyl stationary phase for the dissociation constant (pKa) determination of the tetracycline group antibiotics (tetracycline, oxytetracycline, chlortetracycline) and their epimers (4-epitetracycline, 4-epioxytetracycline, 4-epichlortetracycline). The pH values were measured in the acetonitrile (ACN)–water binary mixtures, used as mobile phases, instead of in water and take into account the effect of the activity coefficients. Thermodynamic acid dissociation constant (pKa1) values of studied antibiotics and their epimers were calculated using retention factor (k) at different mobile phase pH values in studied binary mixtures with ACN percentages of 20, 25, 30 and 35% (v/v). Experimental data were analyzed by using an Origin 7.0 program to fit experimental data to the nonlinear expression derived. From calculated pKa1 values, the aqueous pKa values of studied compounds were calculated by different approaches and these values were compared.

The determination of the second dissociation constant of sulfuric acid

1994 ◽  
Vol 23 (1) ◽  
pp. 75-80 ◽  
Author(s):  
P. Luts ◽  
J. Vanhees ◽  
J. Yperman ◽  
J. Mullens ◽  
L. C. Van Poucke
Keyword(s):  
Sulfuric Acid ◽  
Dissociation Constant ◽  
Second Dissociation Constant
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