Research Progress in Design, Synthesis and Application of Multifunctional Fluorescent Probes

2019 ◽  
Vol 39 (7) ◽  
pp. 1846 ◽  
Author(s):  
Sihong Chen ◽  
Chuming Pang ◽  
Xiaoyun Chen ◽  
Zhihao Yan ◽  
Shimin Huang ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Research Progress ◽  
Design Synthesis

scholarly journals Research Progress in Design, Synthesis and Application of Benzothiazole-Based Fluorescent Probes

2017 ◽  
Vol 37 (9) ◽  
pp. 2221 ◽  
Author(s):  
Kai Jiang ◽  
Liang Cao ◽  
Zhifeng Hao ◽  
Meiyan Chen ◽  
Jieluan Cheng ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Research Progress ◽  
Design Synthesis

scholarly journals Research Progress in Design, Synthesis and Application of Benzo Nitrogen-Containing Heterocyclic Fluorescent Probes

2019 ◽  
Vol 39 (10) ◽  
pp. 2771
Author(s):  
Neng Wang ◽  
Mani Arulkumar ◽  
Xiaoyun Chen ◽  
Bowen Wang ◽  
Sihong Chen ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Research Progress ◽  
Design Synthesis

Selective Selenol Fluorescent Probes: Design, Synthesis, Structural Determinants, and Biological Applications

2015 ◽  
Vol 137 (2) ◽  
pp. 757-769 ◽  
Author(s):  
Baoxin Zhang ◽  
Chunpo Ge ◽  
Juan Yao ◽  
Yaping Liu ◽  
Huichen Xie ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Biological Applications ◽  
Structural Determinants ◽  
Design Synthesis

scholarly journals Design, Synthesis and Evaluation of Enzyme-Responsive Fluorogenic Probes Based on Pyridine-Flanked Diketopyrrolopyrrole Dyes

2020 ◽  
Author(s):  
Sébastien Jenni ◽  
Flavien Ponsot ◽  
Pierre Baroux ◽  
Lucille Collard ◽  
Takayuki Ikeno ◽  
...  
Keyword(s):  
Charge State ◽  
Systematic Study ◽  
Fluorescent Probes ◽  
Penicillin G ◽  
Redox Enzymes ◽  
Design Synthesis ◽  
Rapid Construction ◽  
Fluorogenic Dyes ◽  
Fluorogenic Probes ◽  
Scope Of Application

The ever-growing demand for fluorogenic dyes usable in the rapid construction of analyte-responsive fluorescent probes, has recently contributed to a revival of interest in the chemistry of diketopyrrolopyrrole (DPP) pigments. In this context, we have explored the potential of symmetrical and unsymmetrical DPP derivatives bearing two or one 4-pyridyl substituents acting as optically tunable group(s). The unique fluorogenic behavior of these molecules, closely linked to N-substitution/charge state of their pyridine unit (i.e., neutral pyridine or cationic pyridinium), has been used to design DPP-based fluorescent probes for detection of hypoxia-related redox enzymes and penicillin G acylase (PGA). In this paper, we describe synthesis, spectral characterization and bioanalytical validations of these probes. Dramatic differences in terms of aqueous stability and enzymatic fluorescence activation were observed. This systematic study enables to delineate the scope of application of pyridine-flanked DPP fluorophores in the field of enzyme biosensing.

Design, synthesis and evaluation of curcumin-based fluorescent probes to detect Aβ fibrils

2018 ◽  
Vol 28 (22) ◽  
pp. 3520-3525 ◽  
Author(s):  
Taki Sato ◽  
Mayumi Hotsumi ◽  
Koki Makabe ◽  
Hiroyuki Konno
Keyword(s):  
Fluorescent Probes ◽  
Design Synthesis ◽  
Aβ Fibrils

Design, synthesis and evaluation of novel P450 fluorescent probes bearing α-cyanoether

2003 ◽  
Vol 44 (23) ◽  
pp. 4331-4334 ◽  
Author(s):  
Rong Zhang ◽  
Kyung-Don Kang ◽  
Guomin Shan ◽  
Bruce D. Hammock
Keyword(s):  
Fluorescent Probes ◽  
Design Synthesis

The Research Progress of Direct Thrombin Inhibitors

2020 ◽  
Vol 20 (16) ◽  
pp. 1574-1585
Author(s):  
Zhi-Gang Sun ◽  
Yang-Liu ◽  
Jin-Mai Zhang ◽  
Shi-Chang Cui ◽  
Zhi-Gang Zhang ◽  
...  
Keyword(s):  
High Specificity ◽  
Coagulation Factors ◽  
Fibrin Clot ◽  
Thrombin Inhibitors ◽  
Research Progress ◽  
Direct Thrombin Inhibitors ◽  
Design Synthesis ◽  
Anticoagulant Drug ◽  
Strong Action ◽  
Important Significance

Blood coagulation is the process of changing the blood from the flowing state to the gel state. It is an important part of the hemostatic function. Coagulation is a process by which a series of coagulation factors are sequentially activated, and finally thrombin is formed to form fibrin clot. Direct thrombin inhibitors are important anticoagulant drug. These drugs can selectively bind to the active site of thrombin, inhibit thrombin activity, have strong action and high specificity, and have important significance in the clinical treatment of thrombus diseases. Some of them come from natural products of animals or plants, and many of them have been applied in the clinic. The other part is derived from the design, synthesis and activity studies of small molecule inhibitors. This review discusses the progress of direct thrombin inhibitors in recent years.

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