Design, synthesis, and fluorescence studies of fluorenyl fatty acids as new depth-dependent fluorescent probes for membranes: getting over the looping-back problem

Biochemistry ◽  
1988 ◽  
Vol 27 (25) ◽  
pp. 8981-8989 ◽  
Author(s):  
Anil K. Lala ◽  
R. R. Dixit ◽  
V. Koppaka ◽  
S. Patel
Keyword(s):  
Fatty Acids ◽  
Fluorescent Probes ◽  
Design Synthesis ◽  
Fluorescence Studies ◽  
Back Problem

Selective Selenol Fluorescent Probes: Design, Synthesis, Structural Determinants, and Biological Applications

2015 ◽  
Vol 137 (2) ◽  
pp. 757-769 ◽  
Author(s):  
Baoxin Zhang ◽  
Chunpo Ge ◽  
Juan Yao ◽  
Yaping Liu ◽  
Huichen Xie ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Biological Applications ◽  
Structural Determinants ◽  
Design Synthesis

scholarly journals Research Progress in Design, Synthesis and Application of Benzothiazole-Based Fluorescent Probes

2017 ◽  
Vol 37 (9) ◽  
pp. 2221 ◽  
Author(s):  
Kai Jiang ◽  
Liang Cao ◽  
Zhifeng Hao ◽  
Meiyan Chen ◽  
Jieluan Cheng ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Research Progress ◽  
Design Synthesis

scholarly journals Design, Synthesis and Evaluation of Enzyme-Responsive Fluorogenic Probes Based on Pyridine-Flanked Diketopyrrolopyrrole Dyes

2020 ◽  
Author(s):  
Sébastien Jenni ◽  
Flavien Ponsot ◽  
Pierre Baroux ◽  
Lucille Collard ◽  
Takayuki Ikeno ◽  
...  
Keyword(s):  
Charge State ◽  
Systematic Study ◽  
Fluorescent Probes ◽  
Penicillin G ◽  
Redox Enzymes ◽  
Design Synthesis ◽  
Rapid Construction ◽  
Fluorogenic Dyes ◽  
Fluorogenic Probes ◽  
Scope Of Application

The ever-growing demand for fluorogenic dyes usable in the rapid construction of analyte-responsive fluorescent probes, has recently contributed to a revival of interest in the chemistry of diketopyrrolopyrrole (DPP) pigments. In this context, we have explored the potential of symmetrical and unsymmetrical DPP derivatives bearing two or one 4-pyridyl substituents acting as optically tunable group(s). The unique fluorogenic behavior of these molecules, closely linked to N-substitution/charge state of their pyridine unit (i.e., neutral pyridine or cationic pyridinium), has been used to design DPP-based fluorescent probes for detection of hypoxia-related redox enzymes and penicillin G acylase (PGA). In this paper, we describe synthesis, spectral characterization and bioanalytical validations of these probes. Dramatic differences in terms of aqueous stability and enzymatic fluorescence activation were observed. This systematic study enables to delineate the scope of application of pyridine-flanked DPP fluorophores in the field of enzyme biosensing.

Design, synthesis and evaluation of curcumin-based fluorescent probes to detect Aβ fibrils

2018 ◽  
Vol 28 (22) ◽  
pp. 3520-3525 ◽  
Author(s):  
Taki Sato ◽  
Mayumi Hotsumi ◽  
Koki Makabe ◽  
Hiroyuki Konno
Keyword(s):  
Fluorescent Probes ◽  
Design Synthesis ◽  
Aβ Fibrils

scholarly journals In Vitro Investigations of Acetohexamide Binding to Glycated Serum Albumin in the Presence of Fatty Acid

Molecules ◽  
2020 ◽  
Vol 25 (10) ◽  
pp. 2340 ◽  
Author(s):  
Agnieszka Szkudlarek ◽  
Michał Wilk ◽  
Małgorzata Maciążek-Jurczyk
Keyword(s):  
Fatty Acids ◽  
Serum Albumin ◽  
Glycated Albumin ◽  
Binding Activity ◽  
The Body ◽  
Protein Glycation ◽  
Fluorescence Studies ◽  
Hypoglycaemic Activity ◽  
The One

The interaction of drugs with human serum albumin (HSA) is an important element of therapy. Albumin affects the distribution of the drug substance in the body, as well as its pharmacokinetic and pharmacodynamic properties. On the one hand, inflammation and protein glycation, directly associated with many pathological conditions and old age, can cause structural and functional modification of HSA, causing binding disorders. On the other hand, the widespread availability of various dietary supplements that affect the content of fatty acids in the body means that knowledge of the binding activity of transporting proteins, especially in people with chronic diseases, e.g., diabetes, will achieve satisfactory results of the selected therapy. Therefore, the aim of the present study was to evaluate the effect of a mixture of fatty acids (FA) with different saturated and unsaturated acids on the affinity of acetohexamide (AH), a drug with hypoglycaemic activity for glycated albumin, simulating the state of diabetes in the body. Based on fluorescence studies, we can conclude that the presence of both saturated and unsaturated FA disturbs the binding of AH to glycated albumin. Acetohexamide binds more strongly to defatted albumin than to albumin in the presence of fatty acids. The competitive binding of AH and FA to albumin may influence the concentration of free drug fraction and thus its therapeutic effect.

Design, synthesis and evaluation of novel P450 fluorescent probes bearing α-cyanoether

2003 ◽  
Vol 44 (23) ◽  
pp. 4331-4334 ◽  
Author(s):  
Rong Zhang ◽  
Kyung-Don Kang ◽  
Guomin Shan ◽  
Bruce D. Hammock
Keyword(s):  
Fluorescent Probes ◽  
Design Synthesis

Research Progress in Design, Synthesis and Application of Multifunctional Fluorescent Probes

2019 ◽  
Vol 39 (7) ◽  
pp. 1846 ◽  
Author(s):  
Sihong Chen ◽  
Chuming Pang ◽  
Xiaoyun Chen ◽  
Zhihao Yan ◽  
Shimin Huang ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Research Progress ◽  
Design Synthesis
Sign in / Sign up

Export Citation Format

Share Document