scholarly journals A Limit of Detection of Airborne Chemicals for Developing Analytical Methods.

1992 ◽  
Vol 2 (1) ◽  
pp. 71-78
Author(s):  
Shigeru SUZUKI ◽  
Tomohiko ISHIGURO ◽  
Akio YASUHARA
Keyword(s):  
Analytical Methods ◽  
Limit Of Detection ◽  
Airborne Chemicals

scholarly journals Enzyme Immunoassay for Measuring Aflatoxin B1 in Legal Cannabis

Toxins ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 265 ◽  
Author(s):  
Fabio Di Nardo ◽  
Simone Cavalera ◽  
Claudio Baggiani ◽  
Matteo Chiarello ◽  
Marco Pazzi ◽  
...  
Keyword(s):  
Enzyme Immunoassay ◽  
Aflatoxin B1 ◽  
Analytical Methods ◽  
Limit Of Detection ◽  
Direct Analysis ◽  
Aflatoxin Contamination ◽  
Throughput Capacity ◽  
Human Consumption ◽  
The European Union ◽  
Coefficients Of Variation

The diffusion of the legalization of cannabis for recreational, medicinal and nutraceutical uses requires the development of adequate analytical methods to assure the safety and security of such products. In particular, aflatoxins are considered to pose a major risk for the health of cannabis consumers. Among analytical methods that allows for adequate monitoring of food safety, immunoassays play a major role thanks to their cost-effectiveness, high-throughput capacity, simplicity and limited requirement for equipment and skilled operators. Therefore, a rapid and sensitive enzyme immunoassay has been adapted to measure the most hazardous aflatoxin B1 in cannabis products. The assay was acceptably accurate (recovery rate: 78–136%), reproducible (intra- and inter-assay means coefficients of variation 11.8% and 13.8%, respectively), and sensitive (limit of detection and range of quantification: 0.35 ng mL−1 and 0.4–2 ng mL−1, respectively corresponding to 7 ng g−1 and 8–40 ng g−1 ng g−1 in the plant) and provided results which agreed with a HPLC-MS/MS method for the direct analysis of aflatoxin B1 in cannabis inflorescence and leaves. In addition, the carcinogenic aflatoxin B1 was detected in 50% of the cannabis products analyzed (14 samples collected from small retails) at levels exceeding those admitted by the European Union in commodities intended for direct human consumption, thus envisaging the need for effective surveillance of aflatoxin contamination in legal cannabis.

Immunosensor for estrone with an equal limit of detection as common analytical methods

2004 ◽  
Vol 378 (3) ◽  
pp. 744-745 ◽  
Author(s):  
Jens Tschmelak ◽  
Guenther Proll ◽  
Guenter Gauglitz
Keyword(s):  
Analytical Methods ◽  
Limit Of Detection

scholarly journals Analytical methods for the determination of Cr6+ from fixed source emissions

2020 ◽  
Vol 2 (2) ◽  
pp. 185-192
Author(s):  
Mihaela Petrescu ◽  
◽  
Elena Bucur ◽  
Valeriu Danciulescu ◽  
Andreea Cozea ◽  
...  
Keyword(s):  
Analytical Methods ◽  
Limit Of Detection ◽  
Graphite Furnace ◽  
Absorption Spectrometry ◽  
Operating Conditions ◽  
Molecular Absorption ◽  
Limit Of Quantification ◽  
Furnace Atomization ◽  
Heated Glass

This study aimed to develop two analytical methods for the determination of Cr6+ from fixed source emissions, such as the molecular absorption spectrophotometric method (UV-VIS) and the graphite furnace atomization absorption spectrometry method (GTAAS). The first stage in the development of analytical methods involves establishing the optimal operating conditions for, taking air samples, treating them for analysis, and the proceeding for analysis, followed by validating the method by determining performance parameters. For both methods is highly recommended, the use of isokinetic sampling with a sampling probe by the heated glass, quartz, or PTFE. The limit of detection and the limit of quantification were concluded to be 12.38µg/m3 and 40µg/m3, respectively for the UV-VIS method and the GTAAS method 0.12 µg/m3 and 0.54 µg/m3 respectively.

scholarly journals An Overview of the Analytical Methods for the Determination of Organic Ultraviolet Filters in Cosmetic Products and Human Samples

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4780
Author(s):  
Izabela Narloch ◽  
Grażyna Wejnerowska
Keyword(s):  
Analytical Methods ◽  
Limit Of Detection ◽  
Biological Fluids ◽  
Analytical Techniques ◽  
Detection Accuracy ◽  
Uv Filters ◽  
Cosmetic Products ◽  
Monitoring Protocols ◽  
Accuracy And Repeatability

UV filters are a group of compounds commonly used in different cosmetic products to absorb UV radiation. They are classified into a variety of chemical groups, such as benzophenones, salicylates, benzotriazoles, cinnamates, p-aminobenzoates, triazines, camphor derivatives, etc. Different tests have shown that some of these chemicals are absorbed through the skin and metabolised or bioaccumulated. These processes can cause negative health effects, including mutagenic and cancerogenic ones. Due to the absence of official monitoring protocols, there is an increased number of analytical methods that enable the determination of those compounds in cosmetic samples to ensure user safety, as well as in biological fluids and tissues samples, to obtain more information regarding their behaviour in the human body. This review aimed to show and discuss the published studies concerning analytical methods for the determination of organic UV filters in cosmetic and biological samples. It focused on sample preparation, analytical techniques, and analytical performance (limit of detection, accuracy, and repeatability).

A Novel Validation of Analysis Method for Determining Nicotine Levels in Human Blood Plasma (In vitro) High-Pressure Liquid Chromatography Ultraviolet Detector

2020 ◽  
Vol 10 (02) ◽  
pp. 238-243
Author(s):  
Ghassaq T. Al-Ubaidi ◽  
Ahmed A. Abbas ◽  
Ali A. Taha ◽  
Qasim S. Sharhan
Keyword(s):  
Liquid Chromatography ◽  
Blood Plasma ◽  
Human Blood ◽  
Analytical Methods ◽  
Limit Of Detection ◽  
Uv Detection ◽  
Human Blood Plasma ◽  
Analysis Method ◽  
System Suitability

The necessity of nicotine analysis in blood plasma is increasing along with the increased number of smokers and nicotine poisoning cases. One of the analytical methods for nicotine is using high-performance liquid chromatography (HPLC) with ultraviolet (UV) detector because it has been commonly owned by instance in Indonesia. To guarantee accuracy, an analytical method can be used, and it must be validated. This research was the purpose of finding out the validity of the nicotine analysis method in human blood plasma (in vitro) using HPLC with UV detection. Blood plasma samples remained treated with centrifugation procedure by protein denaturation method using acetonitrile. The compounds were analyzed using methanol and buffer acetate 0.01 M (pH 5) 85:15 v/v as a mobile phase on an octadecylsilane column 250 mm, with UV detection at 254 and 260 nm, and flow rate 0.6 mL/minute. Parameter of analytical methods that were validated includes selectivity, accuracy, precision, repeatability, linearity, limit of detection (LoD), limit of quantification (LoQ), and system suitability. According to the result, the selectivity was 2.479, repeatability expressed by its variation coefficient = 0.701%, linearity at range 5–22 μg/mL expressed by coefficient correlation (r) = 0.996. Based on the chromatogram’s area under a curve, the LoD value was found 2.021 μg/mL, LoQ value was 6.737 μg/mL, the accurate percentage was 112.49 to 114.12%, and precision (% CV) was 2.15 to 3.95%. The system suitability from retention time and chromatogram’s area under curve showed % CV 0.70 and 1.64%. According to the experiment result, all parameters meet the requirements of validation criteria.

scholarly journals Colorimetric hand-held sensors and biosensors with a small digital camera as signal recorder, a review

2020 ◽  
Vol 39 (1) ◽  
pp. 20-30
Author(s):  
Miroslav Pohanka
Keyword(s):  
Analytical Methods ◽  
Limit Of Detection ◽  
Wide Spectrum ◽  
Digital Camera ◽  
Digital Cameras ◽  
Optical Instruments ◽  
Color Density ◽  
Layer Chromatography ◽  
Signal Recorder ◽  
Made In

AbstractSensors, biosensors, lateral flow immunoassays, portable thin-layer chromatography and similar devices for hand-held assay are tools suitable for field or out of laboratories assays of various analytes. The assays frequently exert a limit of detection and sensitivity close to more expensive and elaborative analytical methods. In recent years, huge progress has been made in the field of optical instruments where digital cameras or light sensitive chips serve for the measurement of color density. General availability of cameras, a decrease of prices and their integration into wide spectrum phones, tablets and computers give the promise of easy application of analytical methods where such cameras will be employed. This review summarizes research on hand-held assays where small cameras like the ones integrated into smartphones are used. Discussion about such assays, their practical applicability and relevant specifications are also written here.

scholarly journals Cryptosporidium & Giardia in Water—Key Features and Basic Principles for Monitoring & Data Analysis

Proceedings ◽  
2018 ◽  
Vol 2 (11) ◽  
pp. 691 ◽  
Author(s):  
Jerry E. Ongerth ◽  
Panagiotis Karanis
Keyword(s):  
Data Analysis ◽  
Surface Water ◽  
Analytical Methods ◽  
Limit Of Detection ◽  
Background Information ◽  
Data Sets ◽  
Water Recovery ◽  
Concentration Data ◽  
Effective Manner ◽  
Monitoring Effort

Public health implications of Cryptosporidium and Giardia (C&G) in surface water depend on the characteristics of their occurrence at locations relevant to public water supplies. Recent detailed multi-location and long-term data sets have provided an accurate and complete understanding of occurrence features not previously available. Poisson statistics describe oocyst and cyst concentrations that are characteristically low with respect to the limit of detection of best available analytical methods. The IMS-IFA based analytical methods (e.g., ISO 15553, USEPA 1622/1623) provide reliable data on levels of both C&G in water. Recovery efficiency varies widely and must be measured to give concentration data that can be compared between disparate locations and sampling times. Analysis of samples at a minimum monthly frequency using sufficient sample volumes, e.g., 50 L, has shown that C&G are virtually universal in surface water, continuously, and at levels consistent with catchment conditions. Some basic rules of monitoring and data analysis derived from this background information will ensure that monitoring effort and cost are applied in the most efficient and effective manner.

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