scholarly journals THE PHOTOBIOLOGICAL BASICS BEHIND LIGHT-EMITTING DIODE (LED) PHOTOTHERAPY

LASER THERAPY ◽  
2007 ◽  
Vol 16 (2) ◽  
pp. 97-108 ◽  
Author(s):  
R Glen Calderhead
Keyword(s):  
Light Emitting Diode ◽  
Light Emitting ◽  
Led Phototherapy

scholarly journals Toluidine blue O and porphyrin-mediated photodynamic therapy on three main pathogenic bacteria of periodontitis using portable LED phototherapy device

2015 ◽  
Vol 08 (04) ◽  
pp. 1550017 ◽  
Author(s):  
Xuewei Jiang ◽  
Zhichao Fan ◽  
Yili Yu ◽  
Chenying Shao ◽  
Yuanzhen Suo ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Toluidine Blue ◽  
Pathogenic Bacteria ◽  
Light Emitting Diode ◽  
Red Light ◽  
In Vitro Screening ◽  
Light Emitting ◽  
Led Phototherapy ◽  
Prevotella Melaninogenica

Photodynamic therapy (PDT) has been commonly used in treating many diseases, such as cancer and infectious diseases. We investigated the different effects of PDT on three main pathogenic bacteria of periodontitis — Prevotella melaninogenica (P.m.), Porphyromonas gingivalis (P.g.) and Aggregatibacter actinomycetemcomitans (A.a.). The portable red light-emitting diode (LED) phototherapy device was used to assess the exogenous PDT effects with different light doses and photosensitizer concentrations (Toluidine blue O, TBO). The portable blue LED phototherapy device was used to assess the endogenous PDT effects with the use of endogenous photosensitizers (porphyrin) under different light doses. We found out that both exogenous and endogenous PDT were able to restrict the growth of all the three bacteria significantly. Moreover, the optimal PDT conditions for these bacteria were obtained through this in vitro screening and could guide the clinical PDT on periodontitis.

Effect of the laser and light-emitting diode (LED) phototherapy on midpalatal suture bone formation after rapid maxilla expansion: a Raman spectroscopy analysis

2013 ◽  
Vol 29 (3) ◽  
pp. 859-867 ◽  
Author(s):  
Cristiane Becher Rosa ◽  
Fernando Antonio Lima Habib ◽  
Telma Martins de Araújo ◽  
Juliana Silveira Aragão ◽  
Rafael Soares Gomes ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Bone Formation ◽  
Light Emitting Diode ◽  
Spectroscopy Analysis ◽  
Midpalatal Suture ◽  
Light Emitting ◽  
Led Phototherapy

scholarly journals Effectiveness of light emitting diode versus conventional phototherapy in neonatal hyperbilirubinemia: a hospital based observational study

2020 ◽  
Vol 8 (3) ◽  
pp. 1051
Author(s):  
Radheshyam Purkait ◽  
Manik Mondal
Keyword(s):  
Side Effects ◽  
Light Emitting Diode ◽  
Total Duration ◽  
Conventional Group ◽  
Light Sources ◽  
Fluorescent Lamp ◽  
Light Emitting ◽  
Led Phototherapy ◽  
Significant Difference ◽  
Compact Fluorescent Lamp

Background: The most commonly used light sources in the conventional phototherapy units are compact fluorescent lamp (CFL), halogen spotlights and fiberoptic blankets. Recently light emitting diodes (LED) has emerged as better light source for phototherapy and almost replacing all the available conventional light sources. Comparative studies on the efficacy of LED versus conventional phototherapy are limited from India. That is why; this study was undertaken.Methods: 48 neonates of ≥35 weeks gestational age with hyperbilirubinemia were participated in this study. Among them, 24 neonates received conventional phototherapy and rest of them received LED phototherapy. The rate of fall of bilirubin levels at 6 hours and at completion along with total duration of phototherapy in both groups was measured. Results analysed by standard statistical methods.Results: LED phototherapy units showed higher rate of fall in bilirubin at six hrs (LED group: 0.38±0.05 mg/dl/hr versus conventional group: 0.30±0.04 mg/dl/hr, p<0.05) and after completion of therapy (LED group:                      0.32±0.03 mg/dl/hr versus conventional group: 0.26±0.03 mg/dl/hr, p<0.05) compared to conventional group. Significant difference was documented in total duration of phototherapy in LED group (30.8±1.8 hours) when compared to conventional group (34.6±0.7 hours). None of the neonate showed phototherapy failure. Side effects were minimal and comparable in both the groups.Conclusions: The LED phototherapy units are more efficacious in terms of higher rate of fall of bilirubin levels and lesser duration of phototherapy compared to conventional phototherapy units.

scholarly journals Can exchange transfusion be replaced by double-LED phototherapy?

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 992-996
Author(s):  
Shinya Abe ◽  
Kazumichi Fujioka
Keyword(s):  
Exchange Transfusion ◽  
Light Emitting Diode ◽  
Safe Procedure ◽  
Light Emitting ◽  
Safety Issues ◽  
Led Phototherapy ◽  
Recent Developments ◽  
Good Treatment Strategy ◽  
Severe Hyperbilirubinemia

Abstract Phototherapy is a conventional treatment for neonatal jaundice and widely considered as a safe procedure. Recent developments in light-emitting diode (LED) phototherapy devices have made more effective treatments possible. Exchange transfusion (ET) is typically applied for cases of refractory severe hyperbilirubinemia despite its risk of various complications. Since the therapeutic effect of phototherapy is correlated with its irradiance, ET may be avoided by performing phototherapy with higher irradiation. Recently, we adopted double-LED phototherapy as a bridging treatment to ET to treat a case of severe hyperbilirubinemia. In this case, the continual increase of bilirubin levels was suppressed immediately after its administration, and ET was not required. Throughout the treatment, no complications or increase in oxidative stress was observed. In addition, neurodevelopment was appropriate for the patient’s age at the 1-year follow-up, and no findings of kernicterus, including physical and magnetic resonance imaging findings, were observed. We hypothesized that double-LED phototherapy may be a good treatment strategy to replace ET for infants with severe hyperbilirubinemia; however, further investigations regarding safety issues including acute and long-term complications are needed before clinical adaptation.

scholarly journals Effect of Light-Emitting Diode Phototherapy on Allograft Bone After Open Sinus Lift Surgery: A Randomized Clinical Trial (Concurrent Parallel)

2021 ◽  
Vol 12 (1) ◽  
pp. e16-e16
Author(s):  
Mahnaz Arshad ◽  
Zahra Ghanavati ◽  
Pouyan Aminishakib ◽  
Kamran Rasouli ◽  
Gholamreza Shirani
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Light Emitting Diode ◽  
Low Level Laser Therapy ◽  
Control Group ◽  
Sinus Lift ◽  
Light Emitting ◽  
Led Phototherapy ◽  
Significant Difference ◽  
History Of

Introduction: Phototherapy with a light-emitting diode (LED) is used in medicine due to its potential bio-stimulatory effects on the human body. However, controversy still exists regarding the efficacy of low-level laser therapy (LLLT) and phototherapy with LED. This in vivo study aimed to quantitatively and qualitatively assess the newly formed bone following LED phototherapy of the human maxillary sinuses. Methods: This randomized clinical trial (concurrent parallel) was conducted on 44 patients in two groups (n=22) at the Implant Department of Tehran University of Medical Sciences. Randomization was done by a random sequence generator program. The inclusion criteria were absence of chronic sinusitis and chronic bone marrow conditions, no history of surgery at the site, absence of diabetes mellitus, no history of chemotherapy or radiotherapy, maxillary premolar edentulism, and signing informed consent forms. Group A underwent LED phototherapy with 620 ± 2 nm wavelength for 20 minutes daily for a total of 21 days after sinus lift surgery. Group B served as the control group and did not receive phototherapy. After 6 months, the grafted sites were re-opened for implant placement, and bone biopsy samples were obtained using a trephine bur. The samples were stained with hematoxylin and eosin and inspected under a light microscope. The results were statistically analyzed using the Mann-Whitney U test. Both the surgeon and pathologist were blinded to the group allocation of patients. Results: Forty tissue specimens were analyzed. Insignificant differences existed between the two groups in terms of the degree of inflammation, bone quality, and maturity of collagen. Histological analyses revealed no significant difference in the mineralized areas of bone between the two groups (P>0.05). Conclusion: The results indicated that LED phototherapy cannot significantly enhance osteogenesis after sinus lift surgery. No side effects were observed in the experimental group.

PHOTOTHERAPY FOR MILD TO MODERATE ACNE VULGARIS WITH PORTABLE BLUE AND RED LED

2011 ◽  
Vol 04 (01) ◽  
pp. 45-52 ◽  
Author(s):  
GUANGDA LIU ◽  
CHANGE PAN ◽  
KAI LI ◽  
YUAN TAN ◽  
XUNBIN WEI
Keyword(s):  
Side Effects ◽  
Light Emitting Diode ◽  
Acne Vulgaris ◽  
Red Light ◽  
Light Sources ◽  
Light Emitting ◽  
Led Light ◽  
Led Phototherapy ◽  
Red Led ◽  
Complete Treatment

In this paper, we studied portable blue and red light-emitting-diode (LED) light sources in phototherapy for mild to moderate acne vulgaris to evaluate the efficacy and tolerance of patients. Patients, randomly divided into blue and red groups, received either blue or red LED phototherapy twice a week for four weeks. After complete treatment, the number of lesions reduced by 71.4% in the blue group, in contrast to 19.5% in the red group. No obvious side effects were observed during and one month after the treatment, except for some mild dryness mentioned by several patients.

scholarly journals 830 nm light-emitting diode (led) phototherapy significantly reduced return-to-play in injured university athletes: a pilot study

LASER THERAPY ◽  
2016 ◽  
Vol 25 (1) ◽  
pp. 35-42 ◽  
Author(s):  
John Foley ◽  
David B Vasily ◽  
Jeanna Bradle ◽  
Catharine Rudio ◽  
R Glen Calderhead
Keyword(s):  
Pilot Study ◽  
Light Emitting Diode ◽  
Return To Play ◽  
Light Emitting ◽  
Led Phototherapy ◽  
University Athletes

scholarly journals Blue LED phototherapy in preterm infants: effects on an oxidative marker of DNA damage

2020 ◽  
Vol 105 (6) ◽  
pp. 628-633
Author(s):  
Lori W E van der Schoor ◽  
Martijn H J R van Faassen ◽  
Ido Kema ◽  
Dyvonne H Baptist ◽  
Annelies J Olthuis ◽  
...  
Keyword(s):  
Dna Damage ◽  
Preterm Infants ◽  
Oxidative Dna Damage ◽  
Serum Bilirubin ◽  
Light Emitting Diode ◽  
Total Serum ◽  
Creatinine Ratio ◽  
Light Emitting ◽  
Led Phototherapy ◽  
Observational Cohort

BackgroundPhototherapy is used on the majority of preterm infants with unconjugated hyperbilirubinaemia. The use of fluorescent tube phototherapy is known to induce oxidative DNA damage in infants and has largely been replaced by blue light-emitting diode phototherapy (BLP). To date, it is unknown whether BLP also induces oxidative DNA damage in preterm infants.ObjectiveTo determine whether BLP in preterm infants induces oxidative DNA damage as indicated by 8-hydroxy-2′deoxyguanosine (8-OHdG).DesignObservational cohort study.MethodsUrine samples (n=481) were collected in a cohort of 40 preterm infants (24–32 weeks’ gestational age) during the first week after birth. Urine was analysed for the oxidative marker of DNA damage 8-OHdG and for creatinine, and the 8-OHdG/creatinine ratio was calculated. Durations of phototherapy and levels of irradiance were monitored as well as total serum bilirubin concentrations.ResultsBLP did not alter urinary 8-OHdG/creatinine ratios (B=0.2, 95% CI −6.2 to 6.6) at either low (10–30 µW/cm2/nm) or high (>30 µW/cm2/nm) irradiance: (B=2.3, 95% CI −5.7 to 10.2 and B=−3.0, 95% CI −11.7 to 5.6, respectively). Also, the 8-OHdG/creatinine ratios were independent on phototherapy duration (B=−0.1, 95% CI −0.3 to 0.1).ConclusionsBLP at irradiances up to 35 µW/cm2/nm given to preterm infants ≤32 weeks’ gestation does not affect 8-OHdG, an oxidative marker of DNA damage.

scholarly journals The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Yuan-Yi Chia ◽  
Chien-Cheng Liu ◽  
Guan-Ming Feng ◽  
Chia-Chih Alex Tseng ◽  
Kuo-Chuan Hung ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Proinflammatory Cytokines ◽  
Analgesic Effect ◽  
Light Emitting Diode ◽  
Antinociceptive Effect ◽  
Cyclooxygenase 2 ◽  
Light Emitting ◽  
Led Phototherapy ◽  
Led Therapy ◽  
Cox 2

Background. Light-emitting diode (LED) phototherapy has been reported to relieve pain and enhance tissue repair through several mechanisms. However, the analgesic effect of LED on incised wounds has never been examined.Objectives. We examined the analgesic effect of LED therapy on incision pain and the changes in cyclooxygenase 2 (COX-2), prostaglandin E2 (PGE2), and the proinflammatory cytokines interleukin 6 (IL-6), IL-1β, and tumor necrosis factorα(TNF-α).Methods. Rats received LED therapy on incised skin 6 days before incision (L-I group) or 6 days after incision (I-L group) or from 3 days before incision to 3 days after incision (L-I-L group). Behavioral tests and analysis of skin tissue were performed after LED therapy.Results. LED therapy attenuated the decrease in thermal withdrawal latency in all the irradiated groups and the decrease in the mechanical withdrawal threshold in the L-I group only. The expression levels of COX-2, PGE2, and IL-6 were significantly decreased in the three LED-treated groups, whereas IL-1βand TNF-αwere significantly decreased only in the L-I group compared with their levels in the I groups (p<0.05).Conclusions. LED therapy provides an analgesic effect and modifies the expression of COX-2, PGE2, and proinflammatory cytokines in incised skin.

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