scholarly journals Immunohistochemical Analysis of WT1, EGFR, E-cadherin, beta-catenin and p53 in 43 Moroccan Epithelial Ovarian Tumours

2014 ◽  
pp. 11-17 ◽  
Author(s):  
Mariam Amrani ◽  
Lorenzo Memeo ◽  
Habiba Kadiri ◽  
Hind Charhi ◽  
Mohamed Alaoui Belabbas ◽  
...  
Keyword(s):  
Immunohistochemical Analysis ◽  
Beta Catenin ◽  
Ovarian Tumours ◽  
Epithelial Ovarian Tumours ◽  
E Cadherin

175 The biological relevance of the E-cadherin/catenin complex in epithelial ovarian tumours

2003 ◽  
Vol 1 (5) ◽  
pp. S56
Author(s):  
C. Faleiro Rodrigues ◽  
I. Macedo Pinto ◽  
S. Maia ◽  
R. Vieira ◽  
C. Lopes
Keyword(s):  
Biological Relevance ◽  
Ovarian Tumours ◽  
Epithelial Ovarian Tumours ◽  
E Cadherin

scholarly journals CD44 and E-Cadherin Expression in Primary Epithelial Tumours of Ovary and Comparison with Histological Type and Tumour Differentiation - A Cross-Sectional Study from Thrissur, Kerala

2021 ◽  
Vol 8 (19) ◽  
pp. 1380-1385
Author(s):  
Dhanya Valliapoyil ◽  
Jisha Kalathil Thodiyil ◽  
Lovely Jose
Keyword(s):  
Cross Sectional Study ◽  
Histological Type ◽  
Sectional Study ◽  
Cross Sectional ◽  
Ovarian Tumours ◽  
Epithelial Tumours ◽  
Epithelial Ovarian Tumours ◽  
The Relationship ◽  
Tumour Differentiation ◽  
E Cadherin

BACKGROUND Ovarian tumours are the common cause of morbidity and mortality in women worldwide. Primary epithelial ovarian tumours comprise the majority. Cluster differentiation 44 (CD-44) is a trans-membrane glycoprotein which plays a role in cell- cell interaction, adhesion and migration, leading to the progression and metastasis of tumour. E-cadherin is another cell adhesion molecule which plays an important role in neoplastic progression. So, it is necessary to find out the relationship of CD-44 and E-cadherin expression with histological types and tumour differentiation, which might predict the prognosis. The present study was undertaken to assess the pattern of expression of CD-44 and E-cadherin in primary epithelial tumours of ovary and to determine the relationship between their expression with age, histological type and tumour differentiation. METHODS This is a cross-sectional study conducted in the Department of Pathology, Government Medical College, Thrissur; a tertiary care institution. Histological types and tumour differentiation for each case was determined from haematoxylin and eosin sections. Immunohistochemical stain for CD-44 and E-cadherin was done. Pattern of expression was studied and a semi quantitative score was calculated. Expression of both markers was then compared with the age, histological type and tumour differentiation. RESULTS Out of 57 cases studied, majority of the patients had serous (21 cases) or mucinous tumours (20 cases). The mean age group was 54.5 years. CD-44 expression was significantly correlated with tumour differentiation but there was no correlation found with age and histological type. In E-cadherin expression, there was no correlation with age, histological type and tumour differentiation. CONCLUSIONS For primary epithelial tumours, expression of CD-44 could be an indicator for tumour progression, invasiveness or distant metastasis. Poorly differentiated tumours with increased expression may be helpful in predicting disease progression. Target therapy can be employed in such cases. In case of E-cadherin which is said to be a prognostic marker, more studies help in bridging the gap between prognosis and outcome. KEYWORDS CD-44, E-cadherin, Immunohistochemistry, Epithelial Ovarian Tumours f

Biological Relevance of E-Cadherin-Catenin Complex Proteins in Primary Epithelial Ovarian Tumours

2005 ◽  
Vol 60 (2) ◽  
pp. 75-83 ◽  
Author(s):  
C. Faleiro-Rodrigues ◽  
I.M. Macedo-Pinto ◽  
S.S. Maia ◽  
R.H. Vieira ◽  
C.S. Lopes
Keyword(s):  
Biological Relevance ◽  
Ovarian Tumours ◽  
Epithelial Ovarian Tumours ◽  
E Cadherin

scholarly journals Immunohistochemical analysis of beta-catenin, E-cadherin and p53 in canine gastrointestinal epithelial tumors

2020 ◽  
Vol 82 (9) ◽  
pp. 1277-1286
Author(s):  
Tsubasa SAITO ◽  
James K. CHAMBERS ◽  
Ko NAKASHIMA ◽  
Kazumi NIBE ◽  
Koichi OHNO ◽  
...  
Keyword(s):  
Immunohistochemical Analysis ◽  
Beta Catenin ◽  
Epithelial Tumors ◽  
E Cadherin

733: The Prognostic Value of E-Cadherin, Alpha-, and Beta-Catenin in Invasive Bladder Cancer Patients: Long Term Follow-Up Study

2004 ◽  
Vol 171 (4S) ◽  
pp. 194-195
Author(s):  
Kyoichi Tomita ◽  
Haruki Kume ◽  
Keishi Kashibuchi ◽  
Satoru Muto ◽  
Shigeo Horie ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Invasive Bladder Cancer ◽  
Beta Catenin ◽  
Follow Up Study ◽  
Long Term Follow Up ◽  
E Cadherin

E-cadherin-catenin complex in the rat ovary: cell-specific expression during folliculogenesis and luteal formation

Reproduction ◽  
2000 ◽  
pp. 375-385 ◽  
Author(s):  
K Sundfeldt ◽  
Y Piontkewitz ◽  
H Billig ◽  
L Hedin
Keyword(s):  
Granulosa Cells ◽  
Interstitial Cells ◽  
Ovary Cell ◽  
Beta Catenin ◽  
Oestrogen Treatment ◽  
Altered Expression ◽  
Preantral Follicles ◽  
Rat Ovary ◽  
E Cadherin ◽  
Cell Cell

The cadherins and their cytoplasmic counterparts, the catenins, form the adherens junctions, which are of importance for tissue integrity and barrier functions. The development and maturation of the ovarian follicle is characterized by structural changes, which require altered expression or function of the components involved in cell-cell contacts. The present study examined the cell-specific localization and temporal expression of epithelial cadherin (E-cadherin) and alpha- and beta-catenin during follicular development, ovulation and corpus luteum formation in the immature gonadotrophin- and oestrogen-stimulated rat ovary. Immunohistochemistry and immunoblotting demonstrated the expression of E-cadherin in theca and interstitial cells of immature ovaries before and after injection of equine chorionic gonadotrophin (eCG). E-cadherin was not detected in granulosa cells, except in the preantral follicles located to the inner region of the ovary. The content of E-cadherin in theca and interstitial cells decreased after an ovulatory dose of hCG. Granulosa cells of apoptotic follicles did not express E-cadherin. Oestrogen treatment (diethylstilboestrol) of immature rats for up to 3 days did not result in a measurable expression of E-cadherin in granulosa cells. alpha- and beta-catenin were expressed in all ovarian compartments. The concentration of beta-catenin was constant during the follicular phase, whereas the content of alpha-catenin decreased in granulosa cells after treatment with diethylstilboestrol or hCG. The expression of alpha-catenin was also reduced in theca and interstitial cells after hCG. alpha- and beta-catenin were present in most ovarian cells at all stages of folliculogenesis. Therefore, the catenins have the potential to associate with different members of the cadherin family and to participate in the regulation of cytoskeletal structures and intracellular signalling. The restricted expression of E-cadherin in granulosa cells of preantral follicles indicates a role in the recruitment of these follicles to subsequent cycles. The specific decrease of alpha-catenin in granulosa cells and the reduction of both alpha-catenin and E-cadherin in theca cells of ovulatory follicles might reflect some of the molecular changes in cell-cell adhesion associated with ovulation and luteinization.

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