Biological Relevance of E-Cadherin-Catenin Complex Proteins in Primary Epithelial Ovarian Tumours

2005 ◽  
Vol 60 (2) ◽  
pp. 75-83 ◽  
Author(s):  
C. Faleiro-Rodrigues ◽  
I.M. Macedo-Pinto ◽  
S.S. Maia ◽  
R.H. Vieira ◽  
C.S. Lopes
Keyword(s):  
Biological Relevance ◽  
Ovarian Tumours ◽  
Epithelial Ovarian Tumours ◽  
E Cadherin

175 The biological relevance of the E-cadherin/catenin complex in epithelial ovarian tumours

2003 ◽  
Vol 1 (5) ◽  
pp. S56
Author(s):  
C. Faleiro Rodrigues ◽  
I. Macedo Pinto ◽  
S. Maia ◽  
R. Vieira ◽  
C. Lopes
Keyword(s):  
Biological Relevance ◽  
Ovarian Tumours ◽  
Epithelial Ovarian Tumours ◽  
E Cadherin

scholarly journals CD44 and E-Cadherin Expression in Primary Epithelial Tumours of Ovary and Comparison with Histological Type and Tumour Differentiation - A Cross-Sectional Study from Thrissur, Kerala

2021 ◽  
Vol 8 (19) ◽  
pp. 1380-1385
Author(s):  
Dhanya Valliapoyil ◽  
Jisha Kalathil Thodiyil ◽  
Lovely Jose
Keyword(s):  
Cross Sectional Study ◽  
Histological Type ◽  
Sectional Study ◽  
Cross Sectional ◽  
Ovarian Tumours ◽  
Epithelial Tumours ◽  
Epithelial Ovarian Tumours ◽  
The Relationship ◽  
Tumour Differentiation ◽  
E Cadherin

BACKGROUND Ovarian tumours are the common cause of morbidity and mortality in women worldwide. Primary epithelial ovarian tumours comprise the majority. Cluster differentiation 44 (CD-44) is a trans-membrane glycoprotein which plays a role in cell- cell interaction, adhesion and migration, leading to the progression and metastasis of tumour. E-cadherin is another cell adhesion molecule which plays an important role in neoplastic progression. So, it is necessary to find out the relationship of CD-44 and E-cadherin expression with histological types and tumour differentiation, which might predict the prognosis. The present study was undertaken to assess the pattern of expression of CD-44 and E-cadherin in primary epithelial tumours of ovary and to determine the relationship between their expression with age, histological type and tumour differentiation. METHODS This is a cross-sectional study conducted in the Department of Pathology, Government Medical College, Thrissur; a tertiary care institution. Histological types and tumour differentiation for each case was determined from haematoxylin and eosin sections. Immunohistochemical stain for CD-44 and E-cadherin was done. Pattern of expression was studied and a semi quantitative score was calculated. Expression of both markers was then compared with the age, histological type and tumour differentiation. RESULTS Out of 57 cases studied, majority of the patients had serous (21 cases) or mucinous tumours (20 cases). The mean age group was 54.5 years. CD-44 expression was significantly correlated with tumour differentiation but there was no correlation found with age and histological type. In E-cadherin expression, there was no correlation with age, histological type and tumour differentiation. CONCLUSIONS For primary epithelial tumours, expression of CD-44 could be an indicator for tumour progression, invasiveness or distant metastasis. Poorly differentiated tumours with increased expression may be helpful in predicting disease progression. Target therapy can be employed in such cases. In case of E-cadherin which is said to be a prognostic marker, more studies help in bridging the gap between prognosis and outcome. KEYWORDS CD-44, E-cadherin, Immunohistochemistry, Epithelial Ovarian Tumours f

scholarly journals Immunohistochemical Analysis of WT1, EGFR, E-cadherin, beta-catenin and p53 in 43 Moroccan Epithelial Ovarian Tumours

2014 ◽  
pp. 11-17 ◽  
Author(s):  
Mariam Amrani ◽  
Lorenzo Memeo ◽  
Habiba Kadiri ◽  
Hind Charhi ◽  
Mohamed Alaoui Belabbas ◽  
...  
Keyword(s):  
Immunohistochemical Analysis ◽  
Beta Catenin ◽  
Ovarian Tumours ◽  
Epithelial Ovarian Tumours ◽  
E Cadherin

scholarly journals Nuclear expression of Snail1 in borderline and malignant epithelial ovarian tumours is associated with tumour progression

BMC Cancer ◽  
2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Hanna Tuhkanen ◽  
Ylermi Soini ◽  
Veli-Matti Kosma ◽  
Maarit Anttila ◽  
Reijo Sironen ◽  
...  
Keyword(s):  
Tumour Progression ◽  
Nuclear Expression ◽  
Ovarian Tumours ◽  
Epithelial Ovarian Tumours

scholarly journals The Inhibitory Effect of KIAA1456 on the Proliferation and Metastasis of Epithelial Ovarian Cancer Through SSX1 and AKT Signaling Pathway

2021 ◽  
Author(s):  
Yingfeng Zhang ◽  
Yanhong Gao ◽  
Congcong Sun ◽  
Yanhua Mao ◽  
Benyuan Wu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Tumour Growth ◽  
Molecular Mechanisms ◽  
Signalling Pathway ◽  
Migration And Invasion ◽  
Ovarian Tumours ◽  
Proliferation And Metastasis ◽  
Epithelial Ovarian Tumours

Abstract Background: KIAA1456 is effective in the inhibition of tumorigenesis. We previously confirmed that KIAA1456 inhibits cell proliferation and metastasis in epithelial ovarian tumours. In the current study, the specific molecular mechanisms and clinical significance of KIAA1456 underlying the repression of epithelial ovarian cancer were investigated.Methods: Immunohistochemistry was used to evaluate the protein expression of KIAA1456 and SSX1 in epithelial ovarian tumours and normal ovarian tissues. The relationship of KIAA1456 and SSX1 with overall survival of patients with epithelial ovarian cancer was analysed with Kaplan–Meier survival curve and log-rank tests. KIAA1456 was overexpressed and silenced in HO8910PM cells with a lentivirus. The anticancer activity of KIAA1456 was tested by CCK8, plate clone formation assay, flow cytometry, wound healing assay and Transwell invasion assay. Xenograft tumour models were used to investigate the effects of KIAA1456 on tumour growth in vivo. Bioinformatics analyses of microarray profiling indicated that SSX1 and the PI3K/AKT signalling pathway were differentially expressed in KIAA1456-overexpressing and control cells. Therefore, the biological function of HO8910PM cotransfected with KIAA1456- and SSX1-overexpressing cells was detected to validate the rescue effect of SSX1. The downstream factors of PI3K/AKT that are related to cell growth and apoptosis, including p-AKT, PCNA, MMP9, CyclinD1 and Bcl-2, were detected by Western blot analysis.Results: KIAA1456 expression was lower in epithelial ovarian tumours than in normal ovarian tissues. Its expression level negatively correlated with pathological grade. Pearson’s correlation analysis showed that KIAA1456 negatively correlated with SSX1 expression. The overexpression of KIAA1456 in HO8910PM cells inhibited proliferation, migration and invasion and promoted apoptosis. By contrast, the silencing of KIAA1456 resulted in the opposite behaviour. A xenograft tumour experiment showed that KIAA1456 overexpression inhibited tumour growth in vivo. Mechanistically, the overexpression of KIAA1456 inhibited SSX1 expression and AKT phosphorylation in HO8910PM cells, causing the inactivation of the AKT signalling pathway and eventually reducing the expression of PCNA, CyclinD1, MMP9 and Bcl2. Similarly, the silencing of KIAA1456 resulted in the opposite behaviour. Finally, SSX1 overexpression could partially reverse the KIAA1456-induced biological effect.Conclusion: KIAA1456 may serve as a tumour suppressor via the inactivation of SSX1 and the AKT pathway, providing a promising therapeutic target for epithelial ovarian cancers.

Expression of MUC1 and MUC2 mucins in epithelial ovarian tumours

1997 ◽  
Vol 183 (3) ◽  
pp. 311-317 ◽  
Author(s):  
Ying Dong ◽  
Michael D. Walsh ◽  
Margaret C. Cummings ◽  
R. Gordon Wright ◽  
Soo Keat Khoo ◽  
...  
Keyword(s):  
Ovarian Tumours ◽  
Epithelial Ovarian Tumours

Expression of cancer stem cell markers CD24, EPHA1 and CD9 and their correlation with clinical outcome in epithelial ovarian tumours

2020 ◽  
Vol 28 (3) ◽  
pp. 397-408 ◽  
Author(s):  
Rohit Pravin Nagare ◽  
Smarakan Sneha ◽  
Chirukandath Sidhanth ◽  
S. Roopa ◽  
Kanchan Murhekar ◽  
...  
Keyword(s):  
Stem Cell ◽  
Clinical Outcome ◽  
Cancer Stem Cell ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Cancer Stem Cell Markers ◽  
Ovarian Tumours ◽  
Epithelial Ovarian Tumours
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