scholarly journals DNA damages promoted by the essential oil from leaves of Casearia sylvestris Sw. (Salicaceae)

2016 ◽  
Vol 10 (44) ◽  
pp. 818-822
Author(s):  
G. Pereira Flaviane ◽  
Marquete Ronaldo ◽  
O. Cruz Letícia ◽  
Caldeira-de-Arujo Adriano ◽  
Mansur Elisabeth ◽  
...  
Keyword(s):  
Essential Oil ◽  
Dna Damages ◽  
Casearia Sylvestris

α-zingiberene, a sesquiterpene from essential oil from leaves of Casearia sylvestris, suppresses inflammatory angiogenesis and stimulates collagen deposition in subcutaneous implants in mice

2021 ◽  
pp. 1-5
Author(s):  
Bruno Antonio Ferreira ◽  
Ricardo Ferreira Silva ◽  
Francyelle Borges Rosa de Moura ◽  
Carolina Tannús Narduchi ◽  
Simone Ramos Deconte ◽  
...  
Keyword(s):  
Essential Oil ◽  
Collagen Deposition ◽  
Casearia Sylvestris ◽  
Inflammatory Angiogenesis

scholarly journals Casearia sylvestris essential oil and its fractions inhibit Candida albicans ABC transporters related to multidrug resistance (MDR)

Rodriguésia ◽  
2021 ◽  
Vol 72 ◽  
Author(s):  
Levy Tenorio Sousa Domingos ◽  
Flaviane Gomes Pereira ◽  
Daniel Clemente de Moraes ◽  
Ronaldo Marquete ◽  
Marco Eduardo do Nascimento Rocha ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Multidrug Resistance ◽  
Essential Oil ◽  
Prescription Drugs ◽  
Abc Transporters ◽  
Atp Hydrolysis ◽  
Biological Activities ◽  
Fluconazole Resistance ◽  
Resistance Phenotype ◽  
Casearia Sylvestris

Abstract ABC transporters constitute a superfamily of transmembrane proteins that act mediating the translocation of several substrates across the membrane, using the energy of ATP hydrolysis. This mechanism of unrelated substrates efflux (multidrug resistance) has been associated with several diseases and it is a problem in chemotherapy efficacy. Nowadays, approximately 25% of the prescription drugs in the world are derived from plants. Casearia sylvestris is commonly found in the Americas and different parts of this plant are popularly used to treat several diseases. Previous studies have also confirmed the biological activities of C. sylvestris, such as anti-tumor, anti-leishmania, and antifungal properties. Then, the propose of this study was demonstrate that fraction 1-6 of C. sylvestris, essential oil, was able to reverse the fluconazole resistance phenotype in the Saccharomyces cerevisiae model mediated by the heterologous protein CaCdr2p from Candida albicans. The MIC value of fraction 1-6 combined with fluconazole in the checkerboard assay decreased approximately 4-fold, suggesting a synergistic effect. In addition, fraction 1-6 increased intracellular rhodamine 6G accumulation from 17% to 49% in the presence of glucose. Data indicate that C. sylvestris fraction 1-6 is a potential reverser of the fluconazole resistance phenotype.

scholarly journals Geographical chemical variability and processing oxidation of volatile compounds of Casearia sylvestris leaves

2021 ◽  
Vol 46 (3) ◽  
pp. 42-48
Author(s):  
Flavio Alexandre Carvalho ◽  
Fernando Bombarda Oda ◽  
Ant�nio Eduardo Miller Crotti ◽  
Eduardo Jos� Crevelin ◽  
Andr� Gonzaga Dos Santos
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Volatile Compounds ◽  
Gas Chromatography Mass Spectrometry ◽  
Volatile Components ◽  
Caryophyllene Oxide ◽  
Volatile Chemicals ◽  
Leaf Essential Oil ◽  
Casearia Sylvestris ◽  
Main Components

The Casearia sylvestris Sw. dried leaf essential oil (EO) contains sesquiterpenes as the main components. However, the volatile components in the in natura leaves remain unknown. This study compares the volatile chemicals in the in natura leaves and dried leaf EO of two C. sylvestris populations from Atlantic Forest and Cerrado. The volatile compounds were directly analysed by thermal desorption (TD) coupled to gas chromatography mass spectrometry (GC-MS); the dried leaf EO composition was determined by GC-MS. All the identified compounds were sesquiterpenes, and the major components were (E)-caryophyllene, bicyclogermacrene, ?-elemene, spathulenol, and caryophyllene oxide. In both populations, the sesquiterpene hydrocarbon content and the oxygenated sesquiterpene content respectively decreased and increased on going from the in natura leaves to the dried leaf essential oil, indicating that drying and/or hydrodistillation modified the volatile chemical composition by generating oxidation artifacts. Results suggested that (E)-caryophyllene and bicyclogermacrene may be oxidized during the process to yield caryophyllene oxide and spathulenol, respectively. The two C. sylvestris populations also differed in terms of volatile chemical composition.

scholarly journals EFFECT OF CASEARIA SYLVESTRIS OIL IN CHRONIC INFLAMMATION INDUCED BY SYNTHETIC IMPLANTS IN MICE

2021 ◽  
Vol 7 (2) ◽  
pp. 13
Author(s):  
Natalia Lopes Viana
Keyword(s):  
Essential Oil ◽  
Chronic Inflammation ◽  
Tissue Injury ◽  
Fibrous Tissue ◽  
The Body ◽  
Control Group ◽  
Myeloperoxidase Activity ◽  
Chronic Inflammatory Response ◽  
Significant Difference ◽  
Casearia Sylvestris

Inflammation is a natural body’s event that starts immediately when the body suffers a tissue injury. Its goal is to exterminate the noxious agent, however when the noxious agent is not removed and stands much longer, it is succeeded into a chronic inflammation, what is characterized by the persistence of the harmful agent that can go on for days, months or years. When the chronic inflammation ends, it forms a fibrous tissue. This study we evaluated the effect of the essential oil of Casearia sylvestris used on the traditional medicine. Itis rich in a type of chemical class called sesquiterpene, which is characterized for its anti-inflammatory effect. The inflammatory componentwas measured by myeloperoxidase activity (MPO) and N-acetyl-β-D-glicosaminidase (NAG) and mast cells account. For this purpose, 61 male mices C57∕B1∕6 (control group (saline), DMSO1%, 10 ng, 100 ng, and 1000 ng, of C. sylvestris essential oil) underwent to a chronic inflammatory response induced by synthetic sponge and treated with these dosages. The results have showed that the inflammatory component, represented by the evaluation of MPO and NAG activity, had no significant difference between the three doses evaluated compared to the control group. According to the results, the chronic inflammation treated with C. sylvestris essential oil had no effect on the inflammatory process.

scholarly journals Antimicrobial potential of Casearia sylvestris against oral bacteria

2016 ◽  
Vol 45 (4) ◽  
pp. 214-218 ◽  
Author(s):  
Amanda Henriques CAVALHEIRO ◽  
Ana Paula Terossi GODOI ◽  
Tatiane Cruz de CARVALHO ◽  
Alma Blasida CATIRSE ◽  
Niege Araçari Jacometti Cardoso FURTADO
Keyword(s):  
Antimicrobial Activity ◽  
Minimum Inhibitory Concentration ◽  
Essential Oil ◽  
Inhibitory Concentration ◽  
Minimum Bactericidal Concentration ◽  
Antimicrobial Activities ◽  
Positive Control ◽  
Oral Bacteria ◽  
Volatile Fraction ◽  
Casearia Sylvestris

Abstract Aim The aim of this study was to obtain Casearia sylvestris leave extracts by different extractive methods, including the obtention of essential oil, in order to compare their antimicrobial activities to conventional mouthwash chlorhexidine against oral bacteria. Material and method For this evaluation, extracts from the leaves were obtained by different methods of extraction (infusion, decoction, maceration and percolation) using different solvent systems: water 100%, ethanol 100%, methanol 100%, water: ethanol 3:7; water: ethanol 7:3; water: methanol 7:3 and water: methanol 3:7. The essential oil, which corresponds to a volatile fraction, was obtained by hydrodistillation using Clevenger modified apparatus. The microdilution broth method was used to determine the values of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) for the following microorganisms: Streptococcus mutans ATCC 25175, S. mitis ATCC 49456, S. sanguinis ATCC 10556, S. salivarius ATCC 25975, Lactobacillus casei ATCC 11578 and Enterococcus faecalis ATCC4082. Chlorhexidine gluconate was used as a positive control. Result All extracts evaluated in the used protocol displayed MIC values higher than 400 µg/mL and few showed bactericidal activity. The antimicrobial activity of essential oil was higher than the activity of the extracts, and the best minimum inhibitory concentration and minimum bactericidal concentration values were obtained against L. casei (MIC of 0.023 µg/mL and MBC of 0.046 µg/mL) and S. mutans (MIC of 25 µg/mL and MBC of 50 µg/mL), respectively. Conclusion The essential oil of Casearia sylvestris has significant antimicrobial activity against oral microorganisms.

scholarly journals Cytotoxic evaluation of essential oil from Casearia sylvestris Sw on human cancer cells and erythrocytes

2008 ◽  
Vol 38 (1) ◽  
pp. 107-112 ◽  
Author(s):  
Saulo Luís da Silva ◽  
Jamal da Silva Chaar ◽  
Patrícia de Maria Silva Figueiredo ◽  
Tomomasa Yano
Keyword(s):  
Essential Oil ◽  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Casearia Sylvestris ◽  
Ht 29

A Casearia sylvestris (Flacourtiaceae) é uma planta popularmente conhecida como "guaçatonga" e é usada por povos indígenas da América do sul (Brasil, Peru e Bolivia) no tratamento de muitas doenças, incluindo câncer. Estudos citotóxicos mostraram que esta planta apresenta um possível e interessante potencial antitumoral devido à presença de moléculas chamadas casearinas. Além disso, a composição do óleo essencial mostrou uma alta concentração de sesquiterpenos de alto potencial citotóxico. Neste trabalho, nós verificamos que o óleo essencial da C. sylvestris apresentou uma boa citotoxicidade seletiva contra as linhagens de células tumorais HeLa, A-549 and HT-29 (CD50 63,3, 60,7 e 90,6 µg.ml-1, respectivamente) quando comparada às células não-tumorais Vero (CD50 210,1 µg.ml-1) e macrófagos de camundongos (CD50 234,0 µg.ml-1). Além disso, o óleo causou hemólise em sete diferentes tipos de eritrócitos, indicando que a C. sylvestris precisa ser usada com cuidado. Também foram testados padrões de β-cariofileno e α-humuleno que mostraram citotoxicidade similar àquelas apresentadas pelo óleo, indicando que estes compostos podem ser os responsáveis pelos efeitos tóxicos que foram observados neste estudo.

Gastric antiulcer and anti-inflammatory activities of the essential oil from Casearia sylvestris Sw.

2005 ◽  
Vol 101 (1-3) ◽  
pp. 191-196 ◽  
Author(s):  
Iracema Esteves ◽  
Indira Ramos Souza ◽  
Marcelo Rodrigues ◽  
Luis Gustavo Vieira Cardoso ◽  
Lourivaldo Silva Santos ◽  
...  
Keyword(s):  
Essential Oil ◽  
Casearia Sylvestris ◽  
Anti Inflammatory

scholarly journals Chemical Composition and Cytotoxicity Evaluation of Essential Oil from Leaves of Casearia Sylvestris, Its Main Compound α-Zingiberene and Derivatives

Molecules ◽  
2013 ◽  
Vol 18 (8) ◽  
pp. 9477-9487 ◽  
Author(s):  
Diego Bou ◽  
João Lago ◽  
Carlos Figueiredo ◽  
Alisson Matsuo ◽  
Rafael Guadagnin ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Main Compound ◽  
Casearia Sylvestris

scholarly journals Antifungal activities of the essential oil and its fractions rich in sesquiterpenes from leaves of Casearia sylvestris Sw.

2017 ◽  
Vol 89 (4) ◽  
pp. 2817-2824 ◽  
Author(s):  
FLAVIANE G. PEREIRA ◽  
RONALDO MARQUETE ◽  
LEVY T. DOMINGOS ◽  
MARCO E.N. ROCHA ◽  
ANTONIO FERREIRA-PEREIRA ◽  
...  
Keyword(s):  
Essential Oil ◽  
Antifungal Activities ◽  
Casearia Sylvestris

Casearia sylvestris Essential Oil Degradation Products Generated by Leaf Processing

2021 ◽  
Author(s):  
Flávio Alexandre Carvalho ◽  
Fernando Bombarda Oda ◽  
Antônio Eduardo Miller Crotti ◽  
Eduardo José Crevelin ◽  
André Gonzaga dos Santos
Keyword(s):  
Essential Oil ◽  
Degradation Products ◽  
Oil Degradation ◽  
Leaf Processing ◽  
Casearia Sylvestris
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