Anti-inflammatory activity of Salvia officinalis L.

2012 ◽  
Vol 6 (36) ◽  
Author(s):  
Gessilda Alcantara Nogueira de Melo,
Keyword(s):  
Salvia Officinalis ◽  
Inflammatory Activity ◽  
Anti Inflammatory ◽  
Salvia Officinalis L

scholarly journals New Insights into the Antioxidant and Anti-Inflammatory Effects of Italian Salvia officinalis Leaf and Flower Extracts in Lipopolysaccharide and Tumor-Mediated Inflammation Models

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 311
Author(s):  
Matteo Brindisi ◽  
Chouaha Bouzidi ◽  
Luca Frattaruolo ◽  
Monica R. Loizzo ◽  
Maria Stella Cappello ◽  
...  
Keyword(s):  
Current Knowledge ◽  
Salvia Officinalis ◽  
Inflammatory Activity ◽  
Neoplastic Progression ◽  
Ultrasound Assisted Extraction ◽  
Antioxidant Power ◽  
Ferric Reducing Antioxidant Power ◽  
Anti Inflammatory ◽  
Salvia Officinalis L

This work aimed to investigate and compare the in vitro antioxidant and anti-inflammatory effects of Salvia officinalis L. (sage) from Italy, with the aim of raising its current knowledge in this field. Leaves and flowers (S1–S8), harvested in two areas of Southern Italy, were extracted with methanol as a solvent by maceration or ultrasound-assisted extraction. Sage extracts, analysed by high pressure liquid chromatography-diode-array detection-electrospray ionization-quadrupole-mass spectroscopy (HPLC-DAD-ESI-Q-MS), exerted a promising antioxidant activity investigated using ferric reducing antioxidant power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), and β-carotene bleaching tests, and elicited a significant decrease in reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophages. The anti-inflammatory activity was analysed in the same in vitro model. All the extracts did not affect cell viability although they showed anti-inflammatory activity, as they induced a decrease in nitrite levels that was greater than 50%, when employed at 50 µg/mL. Furthermore, they elicited a decrease in nitrite levels, as well as a decline in pro-inflammatory cytokine expression. The NF-κB transcription factor proved to be involved in the mechanisms that underlie such effects. Interestingly, sage extracts were able to interfere with the inflammatory activity induced by breast cancer cell-conditioned media (nitrite levels were significantly decreased, p < 0.05; p < 0.01), highlighting for the first time the important role of S. officinalis in controlling inflammation processes related to neoplastic progression.

Topical anti-inflammatory activity of Salvia officinalis L. leaves: the relevance of ursolic acid

2001 ◽  
Vol 75 (2-3) ◽  
pp. 125-132 ◽  
Author(s):  
D. Baricevic ◽  
S. Sosa ◽  
R. Della Loggia ◽  
A. Tubaro ◽  
B. Simonovska ◽  
...  
Keyword(s):  
Ursolic Acid ◽  
Salvia Officinalis ◽  
Inflammatory Activity ◽  
Anti Inflammatory ◽  
Salvia Officinalis L

PHYTOCHEMICAL PROFILE AND ANTI-INFLAMMATORY ACTIVITY OF DRY EXTRACTS FROM SALVIA OFFICINALIS LEAVES

Fitoterapia ◽  
2019 ◽  
Vol 4 (4) ◽  
pp. 38-42
Author(s):  
M. M. Myha ◽  
◽  
Yu.V. Verkhovodova ◽  
O. M. Koshovyi ◽  
I. V. Kireyev ◽  
...  
Keyword(s):  
Salvia Officinalis ◽  
Inflammatory Activity ◽  
Phytochemical Profile ◽  
Anti Inflammatory

Anti-inflammatory norabietane diterpenoids from the leaves of Salvia officinalis L.

2019 ◽  
Vol 54 ◽  
pp. 154-163 ◽  
Author(s):  
Lingnan Li ◽  
Shanshan Wei ◽  
Tianyu Zhu ◽  
Guimin Xue ◽  
Dingqiao Xu ◽  
...  
Keyword(s):  
Salvia Officinalis ◽  
Anti Inflammatory ◽  
Salvia Officinalis L

scholarly journals Antioxidant and Anti-Inflammatory Activities of Cytocompatible Salvia officinalis Extracts: A Comparison between Traditional and Soxhlet Extraction

Antioxidants ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 1157
Author(s):  
Sara F. Vieira ◽  
Helena Ferreira ◽  
Nuno M. Neves
Keyword(s):  
Antioxidant Activities ◽  
Inflammatory Diseases ◽  
Soxhlet Extraction ◽  
Salvia Officinalis ◽  
Carnosic Acid ◽  
Inflammatory Activity ◽  
Inflammatory Conditions ◽  
Tnf Α ◽  
Anti Inflammatory ◽  
Layer Chromatography

Chronic inflammation is characterized by an overproduction of several inflammatory mediators (e.g., reactive species and interleukins -IL) that play a central role in numerous diseases. The available therapies are often associated with serious side effects and, consequently, the need for safer drugs is of utmost importance. A plant traditionally used in the treatment of inflammatory conditions is Salvia officinalis. Therefore, conventional maceration and infusion of its leaves were performed to obtain hydroethanolic (HE-T) and aqueous extracts (AE-T), respectively. Their efficacy was compared to soxhlet extracts, namely aqueous (AE-S), hydroethanolic (HE-S), and ethanolic extracts (EE-S). Thin-layer chromatography demonstrated the presence of rosmarinic acid, carnosol, and/or carnosic acid in the different extracts. Generally, soxhlet provided extracts with higher antioxidant activities than traditional extraction. Moreover, under an inflammatory scenario, EE-S were the most effective, followed by HE-S, HE-T, AE-T, and AE-S, in the reduction of IL-6 and TNF-α production. Interestingly, the extracts presented higher or similar anti-inflammatory activity than diclofenac, salicylic acid, and celecoxib. In conclusion, the extraction method and the solvents of extraction influenced the antioxidant activity, but mainly the anti-inflammatory activity of the extracts. Therefore, this natural resource can enable the development of effective treatments for oxidative stress and inflammatory diseases.

Anti-platelet and anti-inflammatory activity of Plumbago zeylanicus (Pz), Phyllanthus emblica (Pe) and their combination

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
DA Uchil ◽  
SK Kamat ◽  
SS Menon ◽  
AM Scindia ◽  
GK Dang ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Phyllanthus Emblica ◽  
Anti Inflammatory
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