scholarly journals The effect of aqueous leaf extract of Adansonia digitata (baobab) on diabetes mellitus and the anterior pituitary of adult male wistar rats

2019 ◽  
Vol 10 (3) ◽  
pp. 18-29
Author(s):  
Pamela Okorie ◽  
Francis Agu ◽  
Celestine Ani ◽  
Ifeoma Alozie ◽  
Choice Nworgu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Adult Male ◽  
Anterior Pituitary ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Adansonia Digitata ◽  
Male Wistar Rats ◽  
Aqueous Leaf Extract

scholarly journals Adansonia digitata aqueous leaf extract ameliorates dexamethasone-induced testicular injury in male Wistar rats

2021 ◽  
Vol 10 (3) ◽  
pp. 113
Author(s):  
AbdulfataiOlakunle Ojewale ◽  
JosephBabatunde Dare ◽  
OlugbemiTope Olaniyan ◽  
JohnAdakole Adole ◽  
GloriaEnevwo Okotie ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Leaf Extract ◽  
Adansonia Digitata ◽  
Male Wistar Rats ◽  
Aqueous Leaf Extract ◽  
Testicular Injury

Profertility effects of aqueous leaf extract of Telfairia occidentalis in adult male Wistar rats

2015 ◽  
Vol 14 (2) ◽  
pp. 88 ◽  
Author(s):  
SakpaLucky Christopher ◽  
Onovughakpo-SakpaOriseseyigbemi Ejuoghanran ◽  
OkhimamheAkhalumhe Festus
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Telfairia Occidentalis ◽  
Male Wistar Rats ◽  
Aqueous Leaf Extract

Adansonia digitata L. leaf extract attenuates lead-induced cortical histoarchitectural changes and oxidative stress in the prefrontal cortex of adult male Wistar rats

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Vivian Atuadu ◽  
Ben-Azu Benneth ◽  
John Oyem ◽  
Emmanuel Esom ◽  
Chris Mba ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prefrontal Cortex ◽  
Lead Acetate ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Neurological Diseases ◽  
Lead Toxicity ◽  
Adansonia Digitata ◽  
Male Wistar Rats ◽  
Aqueous Leaf Extract

AbstractObjectivesAdansonia digitata L. is popularly known for the management of various neurological diseases in ethno-medicine. Studies have shown that lead toxicity is a possible risk factor for early onset of neurodegenerative disease. Hence, this study was designed to evaluate the effect of A. digitata aqueous leaf extract (ADALE) against lead-induced oxidative stress and histo-architectural changes in the prefrontal cortex of adult Wistar rats.MethodsSaline (10 mL/kg), ADALE (500 and 1000 mg/kg) and EDTA (55 mg/kg) were pretreated orally 30 min prior to lead acetate (LA) (120 mg/kg) administration to male Wistar rats (n=7) for 21 days. Thereafter, standard biochemical (superoxide dismutate, catalase, glutathionxe and malondialdehyde), histological (H&E) and histochemical assessment (crystyl fast violet stain for nissil substance) were carried out in the prefrontal cortex.ResultsADALE significantly (p<0.05) reversed LA-induced oxidative stress, as evidenced by increased catalase, superoxide dismutase and oxidized glutathione levels, and decreased malondialdehyde concentration in the prefrontal cortex. Also, the increase chromatolysis and neuronal pyknosis of the pyramidal neurons of the prefrontal cortex were significantly attenuated by ADALE.ConclusionsThe result of this study showed that A. digitata aqueous leaf extract attenuated lead acetate-induced cortical neurodegeneration via inhibition of oxidative stress.

scholarly journals Phytochemical Evaluation and Acute Toxicity Study of Ethanol Leaf Extract of Acalypha wilkesiana

2021 ◽  
Vol 2 (8) ◽  
pp. 715-720
Author(s):  
Anthony Osamuyi Iyamu ◽  
Uwaifoh Akpamu ◽  
Karen Uwarobehi Iyamu
Keyword(s):  
Acute Toxicity ◽  
Adult Male ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Proximate Analysis ◽  
Qualitative And Quantitative ◽  
Benin City ◽  
Synthetic Drugs ◽  
Male Wistar Rats ◽  
Acalypha Wilkesiana

Increased curiosity on natural plant products has been raised due to problems of cost, unavailability, and after-effects of countless synthetic drugs. Worrisome, many plant-derived formulations lack phytochemically or toxicological screening. Hence, this study phytochemical and elemental screened the ethanolic leaf extract of Acalypha wilkesiana and as well as determining acute toxicity in adult male Wistar rats. The leaves were obtained in Benin City, Nigeria. Ethanol extraction was carried out on leaves and the extract was subjected to proximate, qualitative, and quantitative phytochemical screening and elemental analysis. Acute toxicity was determined on 12 adult male Wistar rats following Lork’s method. Proximate analysis revealed a high presence of carbohydrate, ash, fiber, and moisture. The qualitative and quantitative evaluation showed the abundance of alkaloids (68.7 ± 0.120%), flavonoids (34.7 ± 0.001%) and minute (<1mg/g) saponins, tannins, phenol, and terpenes. The extract contain nutritive (vitamin E = 1.184 ± 0.055µg/g; vitamin A = 0.0066 ± 0.003µg/g; vitamin C = 0.046 ± 0.037µg/g) and anti-nutritive (oxalates = 229.780 ± 16.93mg/100g; cyanide=0.162 ± 0.006 mg/100g; phytate = 0.131 ± 0.01mg/100g) elements. The elemental evaluation showed an abundance of potassium, sodium, and chloride with traces of cadmium and lead and the absence of manganese and copper. There was no sign of acute toxicity or mortality at an extract dose of 5000mg/kg. These findings indicate the ethanol leaf extract of A. wilkesiana as a rich source of phytochemicals and major macro elements and high safety at 5000mg/kg dose. Considering the several components in the leaves extract, Acalypha wilkesiana leaf might be pharmacological significant for the biological system.

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