scholarly journals Hypoglycemic and hematological effects of aqueous extract of Thymus serpyllum Linn. in alloxan-induced diabetic rabbits

2012 ◽  
Vol 6 (40) ◽  
pp. 2845-2850 ◽  
Author(s):  
Alamgeer Alamgeer
Keyword(s):  
Aqueous Extract ◽  
Hematological Effects ◽  
Thymus Serpyllum ◽  
Diabetic Rabbits

Anti-Diabetic Effect of a Flavonoid and Sitosterol - Rich Aqueous Extract ofPleurotus tuberregiumSclerotia in Alloxan-Induced Diabetic Rabbits

2019 ◽  
Vol 19 (8) ◽  
pp. 1148-1156 ◽  
Author(s):  
Ifeanacho Mercy Onuekwuzu ◽  
Ikewuchi Catherine Chidinma ◽  
Ikewuchi Jude Chigozie
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Aqueous Extract ◽  
Risk Index ◽  
Fasting Blood Glucose ◽  
Hdl Cholesterol ◽  
The Body ◽  
Atherogenic Index ◽  
Atherogenic Indices ◽  
Diabetic Rabbits

Objective:Traditionally prepared infusions and decoctions are commonly used in the management of diabetes mellitus, in southern Nigeria; one of such is the aqueous extract of the sclerotia of Pleurotus tuberregium (“usu” milk). In this study, the effects of the extract on the body weights, tissue/ organ weights, fasting blood glucose, blood/plasma lipid profiles and atherogenic indices were investigated in normal and alloxan-induced diabetic rabbits.Methods:Diabetes mellitus was induced by the injection of alloxan (120 mg/kg body weight) via the marginal ear vein. The extract was administered orally at 100, 200 and 300 mg/kg to normal and diabetic rabbits; while metformin was administered at 50 mg/kg. The crude extract was analyzed by gas chromatography, coupled to flame ionization detector.Results:Thirty-one known flavonoids were detected, consisting mainly of isoquercetin (28.5%), luteolin (24.3%), quercetin (18.8%) and kaempferol (11.3%). Sitosterol (82.0%) and stigmasterol (12.5%) were the most abundant of the seven phytosterols detected. Compared to the diabetic control, the treatment significantly (p<0.05) lowered the weights of the kidney and liver, as well as the levels of blood glucose and triglyceride, plasma VLDL, LDL and non-HDL cholesterol, atherogenic index of plasma, cardiac risk ratio, atherogenic coefficient and Castelli’s risk index II. It, however, significantly (p<0.05) increased plasma HDL cholesterol, without significantly affecting blood total cholesterol levels.Conclusion:This study showed that the extract was hypoglycemic, and improved lipid profile and atherogenic indices, thus highlighting its cardioprotective potential, thereby supporting its use in the management of diabetes mellitus.

Antihypertensive and hematological effects of Tribulus terrestris Aqueous Extract

2015 ◽  
Vol 3 (8) ◽  
pp. 67-73
Author(s):  
Niemat Ahmed El-Amin Eljabri ◽  
Ahmed Khalil Ahmed ◽  
Awatif Ahmed
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Aqueous Extract ◽  
Perfusion Pressure ◽  
Normal Pressure ◽  
Smooth Muscle Contraction ◽  
Hypotensive Activity ◽  
Tribulus Terrestris ◽  
Curative Effect ◽  
Hematological Effects

The effect of 100 and 50 mg/kg body weight Tribulus terrestris aqueous extract at on the cardiovascular system of rats was studied. Initial heart rate of 160, systolic100 & diastolic 40was considered as normal pressure.. One minute after extract administration the blood pressure and heart rate of rats were raised. The rats' blood pressure continued in a remarkable increasing manner reaching a 180 systolic, 150 diastolic mm/Hg and the heart rate beat were 200, no mortality was observed. Perfusion pressure was raised with the aqueous extract administration then reduced to the normal level after 90 minutes. It was concluded that aqueous extracts of Tribulus terrestris possess significant hypotensive activity in hypertensive rats. The hypotensive effects of Tribulus terrestris appeared may be due to the direct arterial smooth muscle contraction and membrane hypo polarization. These results suggested the curative effect of T. terrestris aqueous extract on hypertensive animals.

Aqueous extract of Paullinia cupana attenuates renal and hematological effects associated with ketoprofen

2020 ◽  
Author(s):  
Caroline Belló ◽  
Ana Paula Prestes ◽  
Josiane Aparecida Schemberger ◽  
Ana Carolina Mendes Hacke ◽  
Romaiana Picada Pereira ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Paullinia Cupana ◽  
Hematological Effects

scholarly journals Effect of aqueous extract of Thymus serpyllum on lipid profile and some liver enzymes in alloxan-induced diabetic rabbit

2017 ◽  
Vol 12 (1) ◽  
pp. 58
Author(s):  
Alamgeer . ◽  
Muhammad Naveed Mushtaq
Keyword(s):  
Lipid Profile ◽  
Aqueous Extract ◽  
Liver Enzymes ◽  
Hdl Cholesterol ◽  
Diabetic Control ◽  
Cholesterol Ratio ◽  
Diabetic Rabbit ◽  
Group 3 ◽  
Group 5 ◽  
Thymus Serpyllum

<p class="Abstract">The present study was designed to evaluate the effects of aqueous extract of<em> Thymus serpyllum</em> on lipid profile and some liver enzymes level in the diabetic rabbit. Rabbits were made diabetic with a single intravenous injection of alloxan and were divided into groups. Group 1 and 2 served as normal and diabetic control, respectively. Group 3 and 4 were given standard drugs glibenclamide and acarbose respectively while Group 5 was treated with 500 mg/kg of extract for 30 days. Blood samples were taken on day 0 and 30. The extract significantly reduced the level of serum cholesterol, triglyceride, LDLs, VLDLs, alkaline phosphatase and transaminases without affecting the HDLs level. Total cholesterol/HDL-cholesterol ratio was significantly reduced as compared to diabetic control. It is conceivable that<em> T. </em>serpyllum possesses antihyperlipidemic and hepatoprotective effects in diabetic rabbit.</p>

Encapsulation of thyme (Thymus serpyllum L.) aqueous extract in calcium alginate beads

2011 ◽  
Vol 92 (3) ◽  
pp. 685-696 ◽  
Author(s):  
Radoslava Stojanovic ◽  
Ana Belscak-Cvitanovic ◽  
Verica Manojlovic ◽  
Drazenka Komes ◽  
Viktor Nedovic ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Calcium Alginate ◽  
Alginate Beads ◽  
Calcium Alginate Beads ◽  
Thymus Serpyllum

scholarly journals ANTI-DIABETIC ACTIVITY

2018 ◽  
Vol 25 (04) ◽  
pp. 502-508
Author(s):  
Muhammad Saleh Faisal ◽  
Usman Nawaz ◽  
Abdul Matin Khan
Keyword(s):  
Body Weight ◽  
Blood Level ◽  
Aqueous Extract ◽  
Study Design ◽  
Methanolic Extract ◽  
P Value ◽  
Aqueous Extracts ◽  
Methanolic Extracts ◽  
Diabetic Rabbits

Objectives: The study was designed to evaluate the hypoglycaemic effects ofCassia sophera’s powdered seeds and its different fractions. Study Design: An experimentalstudy. Setting: Faculty of Veterinary, University of Agriculture, Faisalabad, Pakistan. Period:November 2014 to February 2017. Methodology: Initial experiments were designed to find outthe hypoglycaemic effects of Cassia sophera powdered seeds in increasing doses i.e. 2, 3, 4g/kg body weight at 0, 2, 4, 8, 12 and 24 hours intervals. The effects of methanolic and aqueousextracts equivalent to 4g/kg body weight of Cassia sophera seeds were also studied in bothnormal and diabetic rabbits. Results: At 4 hours interval, 2grams/kg body weight of grindedseeds results no significant decrease in mean blood level of glucose. At 8 and 12 hours intervals,a significant decrease while at 4, 8 and 12 hours a highly significant reduction were observedwith both 3g/kg and 4g/kg body weight. With methanolic and aqueous extracts equivalent to4g/kg body weight, normal rabbits showed significant decrease i.e. with P value less than 0.05at 8 and 12 hours. In addition, the methanolic extract of Cassia sophera seeds produced betterhypoglycaemia as compared to aqueous extract. The effects of these extracts were comparableto Acetohexamide. The same study was also done in alloxan-induced diabetic rabbits and it wasnoticed that Cassia sophera powdered seeds caused significant decrease in blood glucoselevel at increasing doses 2, 3 and 4gram/kg of body weight and highly significant reduction(with P value less than 0.001) in blood level of glucose was noticed with methanolic extracts at4 hours interval which continued upto 8 hours while treatment with aqueous extract with Cassiasophera seeds showed highly significant decrease at 12 hours. Conclusion: It is concludedthat powdered seeds of Cassia sophera constitutes more than one type of hypoglycaemicelements, which have exerted a significant and consistent hypoglycaemic effects in normal andalloxan treated diabetic rabbits.

Modulation of Hematological Indices of Normal and Alloxan-Induced Diabetic Rabbits by Aqueous Extract of Pleurotus tuberregium Sclerotia

2020 ◽  
Vol 20 (3) ◽  
pp. 380-387
Author(s):  
Ifeanacho M. Onuekwuzu ◽  
Ikewuchi C. Chidinma ◽  
Ikewuchi J. Chigozie
Keyword(s):  
Aqueous Extract ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Diabetic Control ◽  
Red Cell ◽  
Distribution Width ◽  
Hematological Indices ◽  
Diabetic Rabbits ◽  
Pleurotus Tuberregium ◽  
Mean Cell Hemoglobin

Objective:: The ability of an aqueous extract of the sclerotia of Pleurotus tuberregium to modulate hematological parameters was investigated in normal and alloxan treated rabbits. Methods:: The extract was subjected to atomic absorption spectrophotometric and flame ionization detector-coupled-gas chromatographic (GC-FID) analysis. Diabetes mellitus was induced by a 120 mg/kg body weight intravenous injection of alloxan. Metformin was orally administered at 50 mg/kg, while the extract was administered (both to normal and diabetic rabbits) at 100, 200 and 300 mg/kg. Results:: Analysis of the extract showed that it had high contents of calcium, magnesium, manganese and potassium. Eleven known glycosides were detected, comprising mainly of amygdalin (37.7%), digoxin (14.4%), dhurrin (14.0%), linamarin (13.6%), prunasin (10.8%) and digitoxin (8.4%). Also detected were twelve known saponins, consisting mainly of sapogenin (40.3%) and neochlorogenin (21.8%); and twelve known lignans, consisting mainly of matairesinol (59.7%), secoisolariciresinol (20.9%) and lariciresinol (14.9%). Compared to the Diabetic control, the hematocrit, hemoglobin concentration, mean cell hemoglobin, mean cell hemoglobin concentration, mean corpuscular volume, red cell distribution width; and red cell, total white cell, lymphocytes, granulocytes and platelet counts of the treated groups were significantly (p<0.05) higher. Conclusion:: The above result showed that the extract had a positive effect on the hemopoietic system of the treated animals, at least at the doses at which it was administered in this study.

Effects of Aqueous Extract of Triplochiton scleroxylon on Red Blood Cells and Associated Parameters in Alloxan - Induced Diabetic Rabbits

2006 ◽  
Vol 5 (5) ◽  
pp. 425-428 ◽  
Author(s):  
T.P. Prohp . ◽  
I.O. Onoagbe . ◽  
P.C. Onyebuagu . ◽  
A.A. Omeni . ◽  
R.I. Okoli . ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Aqueous Extract ◽  
Blood Cells ◽  
Diabetic Rabbits

Effects of Aqueous Extract of Triplochiton scleroxylon on White Blood Cell Differentials in Alloxan-Induced Diabetic Rabbits

2008 ◽  
Vol 7 (2) ◽  
pp. 258-261 ◽  
Author(s):  
T.P. Prohp ◽  
L.C. Anyanwu ◽  
S.C. Uzoaru ◽  
P.C. Onyebuagu ◽  
N. Obeto ◽  
...  
Keyword(s):  
Blood Cell ◽  
Aqueous Extract ◽  
White Blood Cell ◽  
Diabetic Rabbits
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