Aqueous extract of Paullinia cupana attenuates renal and hematological effects associated with ketoprofen

2020 ◽  
Author(s):  
Caroline Belló ◽  
Ana Paula Prestes ◽  
Josiane Aparecida Schemberger ◽  
Ana Carolina Mendes Hacke ◽  
Romaiana Picada Pereira ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Paullinia Cupana ◽  
Hematological Effects

Antihypertensive and hematological effects of Tribulus terrestris Aqueous Extract

2015 ◽  
Vol 3 (8) ◽  
pp. 67-73
Author(s):  
Niemat Ahmed El-Amin Eljabri ◽  
Ahmed Khalil Ahmed ◽  
Awatif Ahmed
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Aqueous Extract ◽  
Perfusion Pressure ◽  
Normal Pressure ◽  
Smooth Muscle Contraction ◽  
Hypotensive Activity ◽  
Tribulus Terrestris ◽  
Curative Effect ◽  
Hematological Effects

The effect of 100 and 50 mg/kg body weight Tribulus terrestris aqueous extract at on the cardiovascular system of rats was studied. Initial heart rate of 160, systolic100 & diastolic 40was considered as normal pressure.. One minute after extract administration the blood pressure and heart rate of rats were raised. The rats' blood pressure continued in a remarkable increasing manner reaching a 180 systolic, 150 diastolic mm/Hg and the heart rate beat were 200, no mortality was observed. Perfusion pressure was raised with the aqueous extract administration then reduced to the normal level after 90 minutes. It was concluded that aqueous extracts of Tribulus terrestris possess significant hypotensive activity in hypertensive rats. The hypotensive effects of Tribulus terrestris appeared may be due to the direct arterial smooth muscle contraction and membrane hypo polarization. These results suggested the curative effect of T. terrestris aqueous extract on hypertensive animals.

scholarly journals Alteration of the Pharmacokinetics of Theophylline by Paullinia cupana Kunth in Rats

2021 ◽  
pp. 12-18
Author(s):  
Nayana Yared Batista ◽  
Ádley Antonini Neves de Lima ◽  
José Wilson do Nascimento Corrêa ◽  
Tatiane Pereira De Souza ◽  
Igor Rafael dos Santos Magalhães
Keyword(s):  
Oral Administration ◽  
Aqueous Extract ◽  
Drug Clearance ◽  
The Other ◽  
Pharmacokinetic Parameters ◽  
Herbal Drug ◽  
Oral Gavage ◽  
Once Daily ◽  
Paullinia Cupana ◽  
Long Time

Aims: Paullinia cupana Kunth has been popularly used to prepare different beverages by the Amazonian inhabitants for a long time ago mainly due to its stimulant properties. Although the utilization of this herbal drug has been increasing lately, little is known regarding the possibility of drug interactions. Therefore, this research tried to investigate the effects of the aqueous extract of P. cupana on the pharmacokinetics of theophylline (TPH), a CYP1A marker in rats. Methodology: The extract was prepared according to the popular recipe and subjects received different once daily doses of extract (vehicle, 82.1 mg/Kg and 821 mg/Kg) by oral gavage during two weeks. Non-compartimental analysis was carried out to obtain the pharmacokinetic parameters. Results: Animals treated with P. cupana (AUC: 1,197.2 ± 284.4 and 346.6 ± 37.0 µg.h/mL for 82.1 and 821 mg/Kg, respectively) had lower exposition to TPH than controls (3,539.48 ± 278.4 µg.h/mL). On the other hand, drug clearance was higher in treated subjects (2.44 ± 0.4 and 7.27 ± 0.7 L/h/kg for 82.1 and 821 mg/Kg, respectively) than controls (0.71 ± 0.0 L/h/kg). Conclusion: Therefore, the multiple oral administration of an aqueous extract of P. cupana caused a significant effect on the pharmacokinetics of TPH in rats.

In vitro effect of an aqueous extract of Artocarpus lakoocha on the intestinal parasites in cattle

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
N Saowakon ◽  
P Chaichanasak ◽  
C Wanichanon ◽  
V Reutrakul ◽  
P Sobhon
Keyword(s):  
Aqueous Extract ◽  
Intestinal Parasites ◽  
Vitro Effect

Attenuation of oxidative stress in hepatic and pancreatic tissues of STZ-induced diabetic rats treated with aqueous extract of Vochysia rufa

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
NM De Gouveia ◽  
IB Moraes ◽  
RMF Sousa ◽  
MB Neto ◽  
AV Mundim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Aqueous Extract ◽  
Diabetic Rats
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