scholarly journals Antioxidant and a-glucosidase inhibitory compounds in Lysimachia clethroides

2012 ◽  
Vol 6 (46) ◽  
pp. 3230-3234 ◽  
Author(s):  
Jin-feng Wei
Keyword(s):  
Inhibitory Compounds ◽  
Lysimachia Clethroides

Early Platelet-Collagen Interactions in Whole Blood and Their Modifications by Aspirin and Dipyridamole Evaluated by a New Method (Basic Wave)

1985 ◽  
Vol 54 (04) ◽  
pp. 799-803 ◽  
Author(s):  
José Luís Pérez-Requejo ◽  
Justo Aznar ◽  
M Teresa Santos ◽  
Juana Vallés
Keyword(s):  
Whole Blood ◽  
Ex Vivo ◽  
Platelet Rich Plasma ◽  
White Blood Cells ◽  
Reversible Aggregation ◽  
Inhibitory Compounds ◽  
Rapid Generation ◽  
Stimulation Of ◽  
Collagen Stimulation

SummaryIt is shown that the supernatant of unstirred whole blood at 37° C, stimulated by 1 μg/ml of collagen for 10 sec, produces a rapid generation of pro and antiaggregatory compounds with a final proaggregatory activity which can be detected for more than 60 min on a platelet rich plasma (PRP) by turbidometric aggregometry. A reversible aggregation wave that we have called BASIC wave (for Blood Aggregation Stimulatory and Inhibitory Compounds) is recorded. The collagen stimulation of unstirred PRP produces a similar but smaller BASIC wave. BASIC’s intensity increases if erythrocytes are added to PRP but decreases if white blood cells are added instead. Aspirin abolishes “ex vivo” the ability of whole blood and PRP to generate BASIC waves and dipyridamole “in vitro” significantly reduces BASIC’s intensity in whole blood in every tested sample, but shows little effect in PRP.

Vernalization Accelerates Flowering of Lysimachia clethroides Duby

HortScience ◽  
1998 ◽  
Vol 33 (3) ◽  
pp. 508b-508
Author(s):  
Pamela M. Lewis ◽  
Alan M. Armitage ◽  
Jim M. Garner
Keyword(s):  
Stem Diameter ◽  
Stem Length ◽  
Cut Flower ◽  
Bud Formation ◽  
Flower Production ◽  
Sphagnum Peat ◽  
Potting Media ◽  
Lysimachia Clethroides ◽  
Shoot Emergence

The effect of vernalization method and duration on off-season cut flower production of Lysimachia clethroides Duby was examined. Rhizomes harvested in October were cooled for 0, 4, 6, 8, 10 or 12 weeks at 4 ± 1 °C in crates with unmilled sphagnum peat or in 3.75-L pots with potting media prior to forcing in a warm greenhouse. After 6 or more weeks of cooling, shoots emerged from crate-cooled rhizomes in higher percentages than from pot-cooled rhizomes. However, only the duration of cooling, not the method, affected the rate of shoot emergence, visible bud formation and anthesis of the first bud in the raceme. As cooling increased from 0 to 12 weeks, the greenhouse days required for shoot emergence, visible bud formation and anthesis decreased linearly. The number of flowering flushes and flowering stems varied quadratically with cooling duration, and the highest yields occurred when rhizomes received between 4 and 10 weeks of cooling. As the number of successive flowering flushes increased, the stem length increased linearly while the stem diameter decreased linearly. High numbers of flowers were produced rapidly after 10 weeks of cooling.

scholarly journals Sorting out the Superbugs: Potential of Sortase A Inhibitors among Other Antimicrobial Strategies to Tackle the Problem of Antibiotic Resistance

Antibiotics ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 164 ◽  
Author(s):  
Nikita Zrelovs ◽  
Viktorija Kurbatska ◽  
Zhanna Rudevica ◽  
Ainars Leonchiks ◽  
Davids Fridmanis
Keyword(s):  
Cell Wall ◽  
Antibiotic Resistance ◽  
Pathogenic Bacteria ◽  
Resistance Mechanisms ◽  
Surface Proteins ◽  
Sortase A ◽  
Inhibitory Compounds ◽  
Alternative Means ◽  
Alternative Approaches ◽  
Conventional Antibiotics

Rapid spread of antibiotic resistance throughout the kingdom bacteria is inevitably bringing humanity towards the “post-antibiotic” era. The emergence of so-called “superbugs”—pathogen strains that develop resistance to multiple conventional antibiotics—is urging researchers around the globe to work on the development or perfecting of alternative means of tackling the pathogenic bacteria infections. Although various conceptually different approaches are being considered, each comes with its advantages and drawbacks. While drug-resistant pathogens are undoubtedly represented by both Gram(+) and Gram(−) bacteria, possible target spectrum across the proposed alternative approaches of tackling them is variable. Numerous anti-virulence strategies aimed at reducing the pathogenicity of target bacteria rather than eliminating them are being considered among such alternative approaches. Sortase A (SrtA) is a membrane-associated cysteine protease that catalyzes a cell wall sorting reaction by which surface proteins, including virulence factors, are anchored to the bacterial cell wall of Gram(+) bacteria. Although SrtA inhibition seems perspective among the Gram-positive pathogen-targeted antivirulence strategies, it still remains less popular than other alternatives. A decrease in virulence due to inactivation of SrtA activity has been extensively studied in Staphylococcus aureus, but it has also been demonstrated in other Gram(+) species. In this manuscript, results of past studies on the discovery of novel SrtA inhibitory compounds and evaluation of their potency were summarized and commented on. Here, we discussed the rationale behind the inhibition of SrtA, raised some concerns on the comparability of the results from different studies, and touched upon the possible resistance mechanisms as a response to implementation of such therapy in practice. The goal of this article is to encourage further studies of SrtA inhibitory compounds.

Removal of enzymatic and fermentation inhibitory compounds from biomass slurries for enhanced biorefinery process efficiencies

2011 ◽  
Vol 102 (17) ◽  
pp. 7850-7859 ◽  
Author(s):  
Raghu N. Gurram ◽  
Saurav Datta ◽  
Yupo J. Lin ◽  
Seth W. Snyder ◽  
Todd J. Menkhaus
Keyword(s):  
Inhibitory Compounds ◽  
Biomass Slurries

scholarly journals A quantitative LumiFluo assay to test inhibitory compounds blocking p53 degradation induced by human papillomavirus oncoprotein E6 in living cells

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Lorenzo Messa ◽  
Marta Celegato ◽  
Chiara Bertagnin ◽  
Beatrice Mercorelli ◽  
Giulio Nannetti ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Living Cells ◽  
Inhibitory Compounds

A novel FTIR-based approach to evaluate the interactions between lignocellulosic inhibitory compounds and their effect on yeast metabolism

RSC Advances ◽  
2016 ◽  
Vol 6 (53) ◽  
pp. 47981-47989 ◽  
Author(s):  
Lorenzo Favaro ◽  
Laura Corte ◽  
Luca Roscini ◽  
Lorenzo Cagnin ◽  
Matteo Tiecco ◽  
...  
Keyword(s):  
Ftir Analysis ◽  
Yeast Metabolism ◽  
Antagonistic Effects ◽  
Inhibitory Compounds

FTIR analysis revealed antagonistic effects between lignocellulosic inhibitory compounds through the metabolomic alterations induced on differentS. cerevisiaestrains.

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