Inhibitory effect of resveratrol on advanced glycation end products-induced mesangial cell proliferation

2012 ◽  
Vol 6 (10) ◽  
Author(s):  
Bei Jiang
Keyword(s):  
Cell Proliferation ◽  
Advanced Glycation End Products ◽  
Mesangial Cell ◽  
Inhibitory Effect ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
Mesangial Cell Proliferation

scholarly journals Inhibitory Activities ofStauntonia hexaphyllaLeaf Constituents on Rat Lens Aldose Reductase and Formation of Advanced Glycation End Products and Antioxidant

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Seung Hwan Hwang ◽  
Shin Hwa Kwon ◽  
Set Byeol Kim ◽  
Soon Sung Lim
Keyword(s):  
Aldose Reductase ◽  
Advanced Glycation End Products ◽  
Inhibitory Activity ◽  
Solvent System ◽  
Inhibitory Effect ◽  
Advanced Glycation ◽  
Rat Lens Aldose Reductase ◽  
Glycation End Products ◽  
End Products ◽  
Etoac Fraction

Stauntonia hexaphylla(Thunb.) Decne. (Lardizabalaceae) leaves (SHL) have been used traditionally as analgesics, sedatives, diuretics, and so on, in China. To date, no data have been reported on the inhibitory effect of SHL and its constituents on rat lens aldose reductase (RLAR) and advanced glycation end products (AGEs). Therefore, the inhibitory effect of compounds isolated from SHL extract on RLAR and AGEs was investigated to evaluate potential treatments of diabetic complications. The ethyl acetate (EtOAC) fraction of SHL extract showed strong inhibitory activity on RLAR and AGEs; therefore, EtOAc fraction (3.0 g) was subjected to Sephadex LH-20 column chromatography, for further fractionation, with 100% MeOH solvent system to investigate its effect on RLAR and AGEs. Phytochemical investigation of SHL led to the isolation of seven compounds. Among the isolated compounds, chlorogenic acid, calceolarioside B, luteolin-3′-O-β-D-glucopyranoside, quercetin-3-O-β-D-glucopyranoside, and luteolin-7-O-β-D-glucopyranoside exhibited significant inhibitory activity against RLAR with IC50in the range of 7.34–23.99 μM. In addition, 3-(3,4-dihydroxyphenyl) propionic acid, neochlorogenic acid, and luteolin-3′-O-β-D-glucopyranoside exhibited the most potent inhibitory activity against formation of AGEs, with an IC50value of 115.07–184.06 μM, compared to the positive control aminoguanidine (820.44 μM). Based on these findings, SHL dietary supplements could be considered for the prevention and/or treatment of diabetes complication.

Inhibitory effect of leonurine on the formation of advanced glycation end products

2015 ◽  
Vol 6 (2) ◽  
pp. 584-589 ◽  
Author(s):  
Lianqi Huang ◽  
Xin Yang ◽  
Anlin Peng ◽  
Hui Wang ◽  
Xiang Lei ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Inhibitory Effect ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
Carbonyl Species

Leonurine inhibits AGE formation through scavenging of the carbonyl species

scholarly journals Resveratrol Prevents Dendritic Cell Maturation in Response to Advanced Glycation End Products

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Brigitta Buttari ◽  
Elisabetta Profumo ◽  
Francesco Facchiano ◽  
Elif Inci Ozturk ◽  
Luca Segoni ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Advanced Glycation End Products ◽  
Map Kinases ◽  
Human Monocyte ◽  
Inhibitory Effect ◽  
The Body ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

Advanced glycation end products (AGEs), generated through nonenzymatic glycosylation of proteins, lipids, and nucleic acids, accumulate in the body by age thus being considered as biomarkers of senescence. Senescence is characterized by a breakdown of immunological self-tolerance, resulting in increased reactivity to self-antigens. Previous findings suggest that AGE and its receptor RAGE may be involved in the pathogenesis of autoimmune reactions through dendritic cell (DC) activation. The aim of this study was to investigate whether resveratrol, a polyphenolic antioxidant compound with tolerogenic effects on DCs, was able to counteract the mechanisms triggered by AGE/RAGE interaction on DCs. By immunochemical and cytofluorimetric assays, we demonstrated thatin vitropretreatment of human monocyte-derived DCs with resveratrol prevents DC activation in response to glucose-treated albumin (AGE-albumin). We found that resveratrol exerts an inhibitory effect on DC surface maturation marker and RAGE up-regulation in response to AGE-albumin. It also inhibited proinflammatory cytokine expression, allostimulatory ability upregulation, mitogen-activated protein (MAP) kinases, and NF-κB activation in AGE-albumin-stimulated DCs. We suggest that resveratrol, by dismantling AGE/RAGE signaling on DCs may prevent or reduce increased reactivity to self-molecules in aging.

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